与COVID-19相关的小儿粘孢子菌病：临床病例的系统回顾

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES Enfermedades infecciosas y microbiologia clinica Pub Date : 2024-06-01 DOI:10.1016/j.eimc.2023.11.002

Laura Batista Amaral , Fabianne Carlesse , Luana Rossato

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引用次数: 0

摘要

在 COVID-19 感染者中发现了粘孢子菌病。然而，有关儿童感染这种疾病的流行病学因素、表现形式、诊断确定性和结果的信息非常有限。从2019年12月到2023年3月，我们系统地检索了PubMed、MEDLINE、Scopus、Embase、Web of Science、LitCovid以及已确定手稿的参考文献。我们在COVID-19患者中发现了14例小儿粘液瘤病。患者的中位年龄为 10.7 岁。在这些病例中，10 例与活跃的 COVID-19 相关。其中7例患者在患病前患有糖尿病，并同时出现糖尿病酮症酸中毒。其中 7 例患者使用皮质类固醇治疗 COVID-19。最常见的临床表现是鼻眶脑粘液瘤病。七名患者死亡（50%）。鉴于该病的高死亡率，临床医生应高度怀疑COVID-19儿童患者患有粘孢子菌病。

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Pediatric mucormycosis associated with COVID-19: A systematic review of clinical cases

The occurrence of mucormycosis has been observed in individuals with COVID-19. However, there is limited information on the epidemiological factors, presentation, diagnostic certainty, and outcome of this infection in children. PubMed, MEDLINE, Scopus, Embase, Web of Science, LitCovid, and back-references of the identified manuscripts were systematically searched from December 2019 to March 2023. We have identified 14 cases of pediatric mucormycosis in patients with COVID-19. The median age of patients was 10.7 years. Among these cases, 10 were associated with active COVID-19. In 7 cases, the patients had pre-existing diabetes mellitus and concomitant diabetic ketoacidosis. Corticosteroids were administered to treat COVID-19 in 7 of the patients. The most common clinical presentation of the disease was rhino-orbital cerebral mucormycosis. Seven patients died (50%). Given the high mortality rate, clinicians should maintain a high level of clinical suspicion of mucormycosis in pediatric patients with COVID-19.

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来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.