{"title":"TNF-α 和电离辐射：在浆细胞性骨髓瘤的致病和治疗中的作用（综述）。","authors":"T F Liubarets","doi":"10.33145/2304-8336-2023-28-65-74","DOIUrl":null,"url":null,"abstract":"<p><p>The review presents data from the literature on the role of Tumor necrosis factor-α (TNF-α) and ionizing radiation (IR) in the pathogenesis and treatment of plasma cell myeloma (PCM). There was analyzed disturbance of regulation of functioning of this cytokine, which affects the interaction of the immune system with substrate plasma cells under the influence of negative external factors, including ionizing radiation IR. Modern directions of therapy of this disease using the latest technologies are presented, in particular CAR T-cell therapy, which will allow to optimize in the future treatment of this disease and, thus, improve the quality and life expectancy of PCM patients.</p>","PeriodicalId":20491,"journal":{"name":"Problemy radiatsiinoi medytsyny ta radiobiolohii","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TNF-α AND IONIZING RADIATION: THE ROLE IN THE PATHOGENESIS AND TREATMENT OF PLASMA CELL MYELOMA (review).\",\"authors\":\"T F Liubarets\",\"doi\":\"10.33145/2304-8336-2023-28-65-74\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The review presents data from the literature on the role of Tumor necrosis factor-α (TNF-α) and ionizing radiation (IR) in the pathogenesis and treatment of plasma cell myeloma (PCM). There was analyzed disturbance of regulation of functioning of this cytokine, which affects the interaction of the immune system with substrate plasma cells under the influence of negative external factors, including ionizing radiation IR. Modern directions of therapy of this disease using the latest technologies are presented, in particular CAR T-cell therapy, which will allow to optimize in the future treatment of this disease and, thus, improve the quality and life expectancy of PCM patients.</p>\",\"PeriodicalId\":20491,\"journal\":{\"name\":\"Problemy radiatsiinoi medytsyny ta radiobiolohii\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Problemy radiatsiinoi medytsyny ta radiobiolohii\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33145/2304-8336-2023-28-65-74\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Problemy radiatsiinoi medytsyny ta radiobiolohii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33145/2304-8336-2023-28-65-74","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
本综述介绍了有关肿瘤坏死因子-α（TNF-α）和电离辐射（IR）在浆细胞骨髓瘤（PCM）发病和治疗中的作用的文献数据。研究分析了这种细胞因子的功能调节紊乱，它在电离辐射 IR 等负外部因素的影响下影响免疫系统与底物浆细胞的相互作用。研究还介绍了利用最新技术治疗这种疾病的现代方向，特别是 CAR T 细胞疗法，这将有助于优化这种疾病的未来治疗，从而提高骨髓增生性白血病患者的质量和预期寿命。
TNF-α AND IONIZING RADIATION: THE ROLE IN THE PATHOGENESIS AND TREATMENT OF PLASMA CELL MYELOMA (review).
The review presents data from the literature on the role of Tumor necrosis factor-α (TNF-α) and ionizing radiation (IR) in the pathogenesis and treatment of plasma cell myeloma (PCM). There was analyzed disturbance of regulation of functioning of this cytokine, which affects the interaction of the immune system with substrate plasma cells under the influence of negative external factors, including ionizing radiation IR. Modern directions of therapy of this disease using the latest technologies are presented, in particular CAR T-cell therapy, which will allow to optimize in the future treatment of this disease and, thus, improve the quality and life expectancy of PCM patients.
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