Maya J. Craig, Kevin J. Cummings, Melissa S. Aprea, Rebecca J. Franklin-Guild, Craig Altier
{"title":"2007-2021 年纽约州中部一家兽医诊断实验室从样本中分离到的牛沙门氏菌的血清型和抗微生物耐药性趋势","authors":"Maya J. Craig, Kevin J. Cummings, Melissa S. Aprea, Rebecca J. Franklin-Guild, Craig Altier","doi":"10.1111/zph.13108","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aims</h3>\n \n <p><i>Salmonella enterica</i> is a leading cause of acute enteritis in people, and dairy cattle are an important reservoir of this pathogen. The objective of this study was to analyse serotype and anti-microbial resistance trends of <i>Salmonella</i> isolated from dairy cattle in the United States between 2007 and 2021.</p>\n </section>\n \n <section>\n \n <h3> Methods and Results</h3>\n \n <p>We collected data for bovine <i>Salmonella</i> isolates obtained from samples submitted to Cornell University's Animal Health Diagnostic Center (AHDC). We analysed 5114 isolates for serotype trends, and a subset of 2521 isolates tested for anti-microbial susceptibility were analysed for resistance trends. The most frequently identified serotypes were <i>Salmonella</i> Cerro, Dublin, Typhimurium, Montevideo, 4,[5],12:i:-, and Newport. Among these serotypes, a Cochran–Armitage trend test determined there was a significant increase in the proportion of isolates serotyped as <i>Salmonella</i> Dublin (<i>p</i> < 0.0001) and Montevideo (<i>p</i> < 0.0001) over time. There was a significant decrease in the proportion of isolates serotyped as <i>Salmonella</i> Cerro (<i>p</i> < 0.0001), Typhimurium (<i>p</i> < 0.0001), and Newport (<i>p</i> < 0.0001). For the anti-microbial resistance (AMR) analysis, we found an overall increase in the proportion of multi-drug-resistant isolates over time (<i>p</i> = 0.009). There was a significant increase in the proportion of isolates resistant to ampicillin (<i>p</i> = 0.007), florfenicol (<i>p</i> = 0.0002), and ceftiofur (<i>p</i> < 0.0001) and a marginal increase in resistance to enrofloxacin (<i>p</i> = 0.05). There was a significant decrease in the proportion of isolates resistant to spectinomycin (<i>p</i> = 0.0002), trimethoprim/sulphamethoxazole (<i>p</i> = 0.01), sulphadimethoxine (<i>p</i> = 0.003), neomycin (<i>p</i> < 0.0001), and gentamicin (<i>p</i> = 0.0002).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Our results provide evidence of an increase in resistance to key anti-microbial agents, although the observed trends were driven by the sharp increase in the proportion of <i>Salmonella</i> Dublin isolates over time.</p>\n </section>\n </div>","PeriodicalId":24025,"journal":{"name":"Zoonoses and Public Health","volume":"71 4","pages":"359-368"},"PeriodicalIF":2.4000,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serotype and anti-microbial resistance trends among bovine Salmonella isolates from samples submitted to a veterinary diagnostic laboratory in central New York, 2007–2021\",\"authors\":\"Maya J. Craig, Kevin J. Cummings, Melissa S. Aprea, Rebecca J. Franklin-Guild, Craig Altier\",\"doi\":\"10.1111/zph.13108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aims</h3>\\n \\n <p><i>Salmonella enterica</i> is a leading cause of acute enteritis in people, and dairy cattle are an important reservoir of this pathogen. The objective of this study was to analyse serotype and anti-microbial resistance trends of <i>Salmonella</i> isolated from dairy cattle in the United States between 2007 and 2021.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods and Results</h3>\\n \\n <p>We collected data for bovine <i>Salmonella</i> isolates obtained from samples submitted to Cornell University's Animal Health Diagnostic Center (AHDC). We analysed 5114 isolates for serotype trends, and a subset of 2521 isolates tested for anti-microbial susceptibility were analysed for resistance trends. The most frequently identified serotypes were <i>Salmonella</i> Cerro, Dublin, Typhimurium, Montevideo, 4,[5],12:i:-, and Newport. Among these serotypes, a Cochran–Armitage trend test determined there was a significant increase in the proportion of isolates serotyped as <i>Salmonella</i> Dublin (<i>p</i> < 0.0001) and Montevideo (<i>p</i> < 0.0001) over time. There was a significant decrease in the proportion of isolates serotyped as <i>Salmonella</i> Cerro (<i>p</i> < 0.0001), Typhimurium (<i>p</i> < 0.0001), and Newport (<i>p</i> < 0.0001). For the anti-microbial resistance (AMR) analysis, we found an overall increase in the proportion of multi-drug-resistant isolates over time (<i>p</i> = 0.009). There was a significant increase in the proportion of isolates resistant to ampicillin (<i>p</i> = 0.007), florfenicol (<i>p</i> = 0.0002), and ceftiofur (<i>p</i> < 0.0001) and a marginal increase in resistance to enrofloxacin (<i>p</i> = 0.05). There was a significant decrease in the proportion of isolates resistant to spectinomycin (<i>p</i> = 0.0002), trimethoprim/sulphamethoxazole (<i>p</i> = 0.01), sulphadimethoxine (<i>p</i> = 0.003), neomycin (<i>p</i> < 0.0001), and gentamicin (<i>p</i> = 0.0002).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Our results provide evidence of an increase in resistance to key anti-microbial agents, although the observed trends were driven by the sharp increase in the proportion of <i>Salmonella</i> Dublin isolates over time.</p>\\n </section>\\n </div>\",\"PeriodicalId\":24025,\"journal\":{\"name\":\"Zoonoses and Public Health\",\"volume\":\"71 4\",\"pages\":\"359-368\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2023-12-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zoonoses and Public Health\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/zph.13108\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zoonoses and Public Health","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/zph.13108","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Serotype and anti-microbial resistance trends among bovine Salmonella isolates from samples submitted to a veterinary diagnostic laboratory in central New York, 2007–2021
Aims
Salmonella enterica is a leading cause of acute enteritis in people, and dairy cattle are an important reservoir of this pathogen. The objective of this study was to analyse serotype and anti-microbial resistance trends of Salmonella isolated from dairy cattle in the United States between 2007 and 2021.
Methods and Results
We collected data for bovine Salmonella isolates obtained from samples submitted to Cornell University's Animal Health Diagnostic Center (AHDC). We analysed 5114 isolates for serotype trends, and a subset of 2521 isolates tested for anti-microbial susceptibility were analysed for resistance trends. The most frequently identified serotypes were Salmonella Cerro, Dublin, Typhimurium, Montevideo, 4,[5],12:i:-, and Newport. Among these serotypes, a Cochran–Armitage trend test determined there was a significant increase in the proportion of isolates serotyped as Salmonella Dublin (p < 0.0001) and Montevideo (p < 0.0001) over time. There was a significant decrease in the proportion of isolates serotyped as Salmonella Cerro (p < 0.0001), Typhimurium (p < 0.0001), and Newport (p < 0.0001). For the anti-microbial resistance (AMR) analysis, we found an overall increase in the proportion of multi-drug-resistant isolates over time (p = 0.009). There was a significant increase in the proportion of isolates resistant to ampicillin (p = 0.007), florfenicol (p = 0.0002), and ceftiofur (p < 0.0001) and a marginal increase in resistance to enrofloxacin (p = 0.05). There was a significant decrease in the proportion of isolates resistant to spectinomycin (p = 0.0002), trimethoprim/sulphamethoxazole (p = 0.01), sulphadimethoxine (p = 0.003), neomycin (p < 0.0001), and gentamicin (p = 0.0002).
Conclusions
Our results provide evidence of an increase in resistance to key anti-microbial agents, although the observed trends were driven by the sharp increase in the proportion of Salmonella Dublin isolates over time.
期刊介绍：
Zoonoses and Public Health brings together veterinary and human health researchers and policy-makers by providing a venue for publishing integrated and global approaches to zoonoses and public health. The Editors will consider papers that focus on timely collaborative and multi-disciplinary research in zoonoses and public health. This journal provides rapid publication of original papers, reviews, and potential discussion papers embracing this collaborative spirit. Papers should advance the scientific knowledge of the sources, transmission, prevention and control of zoonoses and be authored by scientists with expertise in areas such as microbiology, virology, parasitology and epidemiology. Articles that incorporate recent data into new methods, applications, or approaches (e.g. statistical modeling) which enhance public health are strongly encouraged.
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