小鼠穴位猫肠包埋通过抑制TRPV1信号通路减轻纤维肌痛

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Iranian Journal of Basic Medical Sciences Pub Date : 2024-01-01 DOI:10.22038/IJBMS.2023.71431.15534
Feng-Chen Kao, Chia-Ming Yen, Ming-Chia Lin, Hsien-Yin Liao, Hsin-Cheng Hsu, Yi-Wen Lin
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引用次数: 0

摘要

目的:慢性疼痛是指持续三个月以上的疼痛,已成为影响个人和社会的全球性健康问题。慢性广泛性疼痛是纤维肌痛(FM)患者的主要综合征,同时伴有焦虑、肥胖、睡眠障碍和抑郁,有报道称瞬时受体电位香草素 1(TRPV1)可将炎症和疼痛信号传导至大脑:穴位肠套叠(ACE)是一种新型针灸技术,具有持续疗效和方便快捷的特点。ACE在双侧ST36穴进行:结果:我们发现所有组的基线疼痛程度相似。冷应激后,诱发了慢性机械或热痛觉(第 14 天:机械:1.85 ± 0.13 克;热:4.85 ± 0.26 秒),ACE 治疗组(第 14 天:机械:3.99 ± 0.16 克;热:7.42 ± 0.45 秒)和 Trpv1-/- 组(第 14 天,机械:4.25 ± 0.2 克;热:7.91 ± 0.21 秒)小鼠的慢性机械或热痛觉被逆转。FM个体的炎症介质增加,而在ACE管理和TRPV1基因缺失后,炎症介质减少。在 FM 小鼠的丘脑(THA)、躯体感觉皮层(SSC)、内侧前额叶皮层(mPFC)和前扣带回皮层(ACC)中,TRPV1 及其相关介质均有所增加。这些介质的上调在 ACE 和 Trpv1-/- 组中有所减弱:结论:我们认为慢性疼痛可以通过 ACE 或 Trpv1-/- 调节。结论:我们认为,慢性疼痛可通过 ACE 或 Trpv1-/- 调节,ACE 通过 TRPV1 信号通路诱导的镇痛可能是治疗 FM 的有益靶点。
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Acupoint catgut embedding attenuates fibromyalgia pain through attenuation of TRPV1 signaling pathway in mouse.

Objectives: Chronic pain is considered as pain lasting for more than three months and has emerged as a global health problem affecting individuals and society. Chronic extensive pain is the main syndrome upsetting individuals with fibromyalgia (FM), accompanied by anxiety, obesity, sleep disturbances, and depression, Transient receptor potential vanilloid 1 (TRPV1) has been reported to transduce inflammatory and pain signals to the brain.

Materials and methods: Acupoint catgut embedding (ACE) is a novel acupuncture technique that provides continuous effects and convenience. ACE was performed at the bilateral ST36 acupoint.

Results: We demonstrated similar pain levels among all groups at baseline. After cold stress, chronic mechanical or thermal nociception was induced (D14: mechanical: 1.85 ± 0.13 g; thermal: 4.85 ± 0.26 s) and reversed in ACE-treated mice (D14: mechanical: 3.99 ± 0.16 g; thermal: 7.42 ± 0.45 s) as well as Trpv1-/- group (Day 14, mechanical: 4.25 ± 0.2 g; thermal: 7.91 ± 0.21 s) mice. Inflammatory mediators were augmented in FM individuals and were abridged after ACE management and TRPV1 gene loss. TRPV1 and its linked mediators were increased in the thalamus (THA), somatosensory cortex (SSC), medial prefrontal cortex (mPFC), and anterior cingulate cortex (ACC) in FM mice. The up-regulation of these mediators was diminished in ACE and Trpv1-/- groups.

Conclusion: We suggest that chronic pain can be modulated by ACE or Trpv1-/-. ACE-induced analgesia via TRPV1 signaling pathways may be beneficial targets for FM treatment.

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来源期刊
Iranian Journal of Basic Medical Sciences
Iranian Journal of Basic Medical Sciences MEDICINE, RESEARCH & EXPERIMENTAL-PHARMACOLOGY & PHARMACY
CiteScore
4.00
自引率
4.50%
发文量
142
审稿时长
6-12 weeks
期刊介绍: The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran . The Journal of "IJBMS” is a modern forum for scientific communication. Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, Immunology, Microbiology, Pathology, Pharmacology, Pharmaceutical Sciences, and Physiology, will be published after they have been peer reviewed. This will also include reviews and multidisciplinary research.
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