Victoria A Sanchez, Michelle L Arnold, Joshua F Betz, Nicholas S Reed, Sarah Faucette, Elizabeth Anderson, Sheila Burgard, Josef Coresh, Jennifer A Deal, Ann Clock Eddins, Adele M Goman, Nancy W Glynn, Lisa Gravens-Mueller, Jaime Hampton, Kathleen M Hayden, Alison R Huang, Kaila Liou, Christine M Mitchell, Thomas H Mosley, Haley N Neil, James S Pankow, James R Pike, Jennifer A Schrack, Laura Sherry, Katherine H Teece, Kerry Witherell, Frank R Lin, Theresa H Chisolm
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引用次数: 0
摘要
目的：老年人老龄化与认知健康评估（ACHIEVE）研究是一项随机临床试验，旨在确定最佳听力干预与成功的老龄化健康教育对照干预对患有轻度至中度听力损失且未经治疗的社区老年人认知能力下降的影响。我们描述了 ACHIEVE 参与者的基线听力特征：年龄在 70-84 岁之间的参与者（N = 977；Mage = 76.8）通过两种招募途径在美国的四个地点进行招募：（a）正在进行的纵向研究；（b）通过社区从新招募。参与者接受了诊断评估，包括耳镜检查、鼓室测听、纯音和言语测听、噪声言语测试，并提供了自我报告的听力能力。对于分类变量，基线特征以频率（百分比）表示；对于连续变量，基线特征以中位数（四分位数，Q1-Q3）表示。对于分类变量，采用卡方检验进行组间比较；对于连续变量，采用 Kruskal-Wallis 检验进行组间比较。斯皮尔曼相关性评估了测量的听力功能与自我报告的听力障碍之间的关系：较好耳的四频纯音平均值中位数为 39 dB HL，噪声中言语表现的中位数为 6 dB SNR 损失，表明噪声中言语有轻度困难。不同地点之间未发现有临床意义的差异。招聘路线的主观测量结果存在显著差异。听力测量结果与自我报告的障碍之间存在预期的相关性：本文报告的大量基线听力特征将为未来研究听力损失与认知能力下降之间关系的分析提供依据。最终的 ACHIEVE 数据集将公开供科学界使用。补充材料：https://doi.org/10.23641/asha.24756948。
Description of the Baseline Audiologic Characteristics of the Participants Enrolled in the Aging and Cognitive Health Evaluation in Elders Study.
Purpose: The Aging and Cognitive Health Evaluation in Elders (ACHIEVE) study is a randomized clinical trial designed to determine the effects of a best-practice hearing intervention versus a successful aging health education control intervention on cognitive decline among community-dwelling older adults with untreated mild-to-moderate hearing loss. We describe the baseline audiologic characteristics of the ACHIEVE participants.
Method: Participants aged 70-84 years (N = 977; Mage = 76.8) were enrolled at four U.S. sites through two recruitment routes: (a) an ongoing longitudinal study and (b) de novo through the community. Participants underwent diagnostic evaluation including otoscopy, tympanometry, pure-tone and speech audiometry, speech-in-noise testing, and provided self-reported hearing abilities. Baseline characteristics are reported as frequencies (percentages) for categorical variables or medians (interquartiles, Q1-Q3) for continuous variables. Between-groups comparisons were conducted using chi-square tests for categorical variables or Kruskal-Wallis test for continuous variables. Spearman correlations assessed relationships between measured hearing function and self-reported hearing handicap.
Results: The median four-frequency pure-tone average of the better ear was 39 dB HL, and the median speech-in-noise performance was a 6-dB SNR loss, indicating mild speech-in-noise difficulty. No clinically meaningful differences were found across sites. Significant differences in subjective measures were found for recruitment route. Expected correlations between hearing measurements and self-reported handicap were found.
Conclusions: The extensive baseline audiologic characteristics reported here will inform future analyses examining associations between hearing loss and cognitive decline. The final ACHIEVE data set will be publicly available for use among the scientific community.
期刊介绍：
Mission: AJA publishes peer-reviewed research and other scholarly articles pertaining to clinical audiology methods and issues, and serves as an outlet for discussion of related professional and educational issues and ideas. The journal is an international outlet for research on clinical research pertaining to screening, diagnosis, management and outcomes of hearing and balance disorders as well as the etiologies and characteristics of these disorders. The clinical orientation of the journal allows for the publication of reports on audiology as implemented nationally and internationally, including novel clinical procedures, approaches, and cases. AJA seeks to advance evidence-based practice by disseminating the results of new studies as well as providing a forum for critical reviews and meta-analyses of previously published work.
Scope: The broad field of clinical audiology, including audiologic/aural rehabilitation; balance and balance disorders; cultural and linguistic diversity; detection, diagnosis, prevention, habilitation, rehabilitation, and monitoring of hearing loss; hearing aids, cochlear implants, and hearing-assistive technology; hearing disorders; lifespan perspectives on auditory function; speech perception; and tinnitus.
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