治疗非酒精性脂肪肝(NAFLD)和肝纤维化的功能性食品化学成分策略:化学特性、健康益处、作用和应用。

IF 4.6 3区 医学 Q1 NUTRITION & DIETETICS Current Nutrition Reports Pub Date : 2024-03-01 Epub Date: 2024-01-03 DOI:10.1007/s13668-023-00514-8
Chong Yu, Xiaohe Guo, Xiaohang Cui, Guangyue Su, Haifeng Wang
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引用次数: 0

摘要

回顾的目的:肝脏是人体重要的消化腺。生活方式和饮食习惯正日益损害我们的肝脏,导致各种疾病和健康问题。非酒精性脂肪肝已成为全球最严重的肝病问题之一。饮食是维持肝脏健康的重要因素之一。功能食品及其成分已被确定为日常生活中预防和治疗肝病的潜在预防剂的新来源。然而,人们尚未系统地总结食品中由小分子衍生的功能成分对不同类型肝病的影响:最新发现:功能性食品中的成分和相关机制在非酒精性脂肪肝和肝纤维化的发生和发展过程中发挥着重要作用。研究发现,黄酮类化合物、生物碱、多酚、多糖、不饱和脂肪酸和多肽等多种结构成分可通过不同机制治疗和预防非酒精性脂肪肝和肝纤维化。另一方面,相关机制包括氧化应激、炎症和免疫调节,大量文献研究证实了这些机制之间的密切关系。本文旨在研究目前与用于治疗和预防非酒精性脂肪肝和肝纤维化的功能食品和功能成分相关的文献,重点关注化学特性、健康益处、作用机制以及在体外和体内的应用。此外,还讨论了不同成分在非酒精性脂肪肝和肝纤维化生物过程中的作用。
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Functional Food Chemical Ingredient Strategies for Non-alcoholic Fatty Liver Disease (NAFLD) and Hepatic Fibrosis: Chemical Properties, Health Benefits, Action, and Application.

Purpose of review: The liver is an important digestive gland in the body. Lifestyle and dietary habits are increasingly damaging our liver, leading to various diseases and health problems. Non-alcoholic fatty liver disease (NAFLD) has become one of the most serious liver disease problems in the world. Diet is one of the important factors in maintaining liver health. Functional foods and their components have been identified as novel sources of potential preventive agents in the prevention and treatment of liver disease in daily life. However, the effects of functional components derived from small molecules in food on different types of liver diseases have not been systematically summarized.

Recent findings: The components and related mechanisms in functional foods play a significant role in the development and progression of NAFLD and liver fibrosis. A variety of structural components are found to treat and prevent NAFLD and liver fibrosis through different mechanisms, including flavonoids, alkaloids, polyphenols, polysaccharides, unsaturated fatty acids, and peptides. On the other hand, the relevant mechanisms include oxidative stress, inflammation, and immune regulation, and a large number of literature studies have confirmed a close relationship between the mechanisms. The purpose of this article is to examine the current literature related to functional foods and functional components used for the treatment and protection against NAFLD and hepatic fibrosis, focusing on chemical properties, health benefits, mechanisms of action, and application in vitro and in vivo. The roles of different components in the biological processes of NAFLD and liver fibrosis were also discussed.

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来源期刊
Current Nutrition Reports
Current Nutrition Reports Agricultural and Biological Sciences-Food Science
CiteScore
7.70
自引率
2.00%
发文量
59
期刊介绍: This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
期刊最新文献
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