David Deutsch, Michel Bouchoucha, Julien Uzan, Gheorghe Airinei, Jean-Marc Sabate, Robert Benamouzig
{"title":"根据便秘患者的表型,进食后结肠转运反应与自我报告的便秘严重程度之间的关系。","authors":"David Deutsch, Michel Bouchoucha, Julien Uzan, Gheorghe Airinei, Jean-Marc Sabate, Robert Benamouzig","doi":"10.5056/jnm21091","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aims: </strong>Eating is the major synchronizer of gastrointestinal motility and secretions. The present study aims to evaluate the interplay between self-perceived constipation severity (CS) and colonic response to eating in constipated patients according to the phenotype.</p><p><strong>Methods: </strong>We included 387 consecutive outpatients complaining of Rome IV chronic idiopathic constipation. Likert scales for CS, abdominal pain severity, bloating severity, depression and anxiety assessment, total and segmental colonic transit time (CTT), and colonic transit response to eating (CTRE) were performed in all patients.</p><p><strong>Results: </strong>Of the 387 patients included (49.7 ± 16.4 years), 320 (83%) were female, 203 had irritable bowel syndrome with constipation (IBS-C), 184 as functional constipation (FC), and 283 had defecation disorders (DD). The female gender was characterized by increased bloating severity (<i>P</i> = 0.011) and decreased Bristol stool form (<i>P</i> = 0.002). In IBS-C and FC patients, CS was related with bloating severity (<i>P</i> < 0.001 in both groups) and total CTT (<i>P</i> = 0.007 in IBS-constipation, <i>P</i> = 0.040 in FC). In IBS-C patients, CS was also associated with abdominal pain severity (<i>P</i> = 0.003) and Bristol stool form (<i>P</i> = 0.004). In contrast, in FC, CS was only related to left CTRE (<i>P</i> = 0.006), and in patients with DD, CS was associated with total CTT (<i>P</i> < 0.001) and left CTRE (<i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>Colonic transit response to eating was not associated to CS in IBS-C patients, but left CTRE was associated with constipation severity in FC and DD patients.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"30 1","pages":"97-105"},"PeriodicalIF":3.3000,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774807/pdf/","citationCount":"0","resultStr":"{\"title\":\"Relationship Between Colonic Transit Response to Eating With Self-reported Constipation Severity in Constipated Patients According to the Phenotype.\",\"authors\":\"David Deutsch, Michel Bouchoucha, Julien Uzan, Gheorghe Airinei, Jean-Marc Sabate, Robert Benamouzig\",\"doi\":\"10.5056/jnm21091\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aims: </strong>Eating is the major synchronizer of gastrointestinal motility and secretions. The present study aims to evaluate the interplay between self-perceived constipation severity (CS) and colonic response to eating in constipated patients according to the phenotype.</p><p><strong>Methods: </strong>We included 387 consecutive outpatients complaining of Rome IV chronic idiopathic constipation. Likert scales for CS, abdominal pain severity, bloating severity, depression and anxiety assessment, total and segmental colonic transit time (CTT), and colonic transit response to eating (CTRE) were performed in all patients.</p><p><strong>Results: </strong>Of the 387 patients included (49.7 ± 16.4 years), 320 (83%) were female, 203 had irritable bowel syndrome with constipation (IBS-C), 184 as functional constipation (FC), and 283 had defecation disorders (DD). The female gender was characterized by increased bloating severity (<i>P</i> = 0.011) and decreased Bristol stool form (<i>P</i> = 0.002). In IBS-C and FC patients, CS was related with bloating severity (<i>P</i> < 0.001 in both groups) and total CTT (<i>P</i> = 0.007 in IBS-constipation, <i>P</i> = 0.040 in FC). In IBS-C patients, CS was also associated with abdominal pain severity (<i>P</i> = 0.003) and Bristol stool form (<i>P</i> = 0.004). In contrast, in FC, CS was only related to left CTRE (<i>P</i> = 0.006), and in patients with DD, CS was associated with total CTT (<i>P</i> < 0.001) and left CTRE (<i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>Colonic transit response to eating was not associated to CS in IBS-C patients, but left CTRE was associated with constipation severity in FC and DD patients.</p>\",\"PeriodicalId\":16543,\"journal\":{\"name\":\"Journal of Neurogastroenterology and Motility\",\"volume\":\"30 1\",\"pages\":\"97-105\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-01-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774807/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neurogastroenterology and Motility\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5056/jnm21091\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurogastroenterology and Motility","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5056/jnm21091","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景/目的:进食是胃肠道蠕动和分泌的主要同步器。本研究旨在根据表型评估便秘患者自我感觉的便秘严重程度(CS)与结肠对进食的反应之间的相互作用:我们纳入了 387 名主诉患有罗马 IV 型慢性特发性便秘的连续门诊患者。对所有患者进行了CS、腹痛严重程度、腹胀严重程度、抑郁和焦虑评估、结肠总通过时间(CTT)和节段性结肠通过时间(CTT)以及进食后结肠通过反应(CTRE)的李克特量表测量:在纳入的 387 名患者(49.7 ± 16.4 岁)中,320 人(83%)为女性,203 人患有肠易激综合征伴便秘(IBS-C),184 人患有功能性便秘(FC),283 人患有排便障碍(DD)。女性的特点是腹胀严重程度增加(P = 0.011)和布里斯托粪便形态减少(P = 0.002)。在 IBS-C 和 FC 患者中,CS 与腹胀严重程度(两组中的 P 均小于 0.001)和 CTT 总量(IBS-便秘患者中的 P = 0.007,FC 患者中的 P = 0.040)有关。在 IBS-C 患者中,CS 还与腹痛严重程度(P = 0.003)和布里斯托粪便形态(P = 0.004)相关。相反,在 FC 患者中,CS 仅与左侧 CTRE 相关(P = 0.006),而在 DD 患者中,CS 与总 CTT(P < 0.001)和左侧 CTRE(P = 0.002)相关:结论:IBS-C 患者进食后的结肠转运反应与 CS 无关,但左侧 CTRE 与 FC 和 DD 患者的便秘严重程度有关。
Relationship Between Colonic Transit Response to Eating With Self-reported Constipation Severity in Constipated Patients According to the Phenotype.
Background/aims: Eating is the major synchronizer of gastrointestinal motility and secretions. The present study aims to evaluate the interplay between self-perceived constipation severity (CS) and colonic response to eating in constipated patients according to the phenotype.
Methods: We included 387 consecutive outpatients complaining of Rome IV chronic idiopathic constipation. Likert scales for CS, abdominal pain severity, bloating severity, depression and anxiety assessment, total and segmental colonic transit time (CTT), and colonic transit response to eating (CTRE) were performed in all patients.
Results: Of the 387 patients included (49.7 ± 16.4 years), 320 (83%) were female, 203 had irritable bowel syndrome with constipation (IBS-C), 184 as functional constipation (FC), and 283 had defecation disorders (DD). The female gender was characterized by increased bloating severity (P = 0.011) and decreased Bristol stool form (P = 0.002). In IBS-C and FC patients, CS was related with bloating severity (P < 0.001 in both groups) and total CTT (P = 0.007 in IBS-constipation, P = 0.040 in FC). In IBS-C patients, CS was also associated with abdominal pain severity (P = 0.003) and Bristol stool form (P = 0.004). In contrast, in FC, CS was only related to left CTRE (P = 0.006), and in patients with DD, CS was associated with total CTT (P < 0.001) and left CTRE (P = 0.002).
Conclusion: Colonic transit response to eating was not associated to CS in IBS-C patients, but left CTRE was associated with constipation severity in FC and DD patients.
期刊介绍:
Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.