排出尿液中的多重荧光原位杂交状态可提高上尿路泌尿道癌的诊断效率

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY Urology Journal Pub Date : 2024-03-24 DOI:10.22037/uj.v20i.7973

Feng Tang, Xia Wang, Tao Liu, Hao Wang, Ziyu Wan, Qiqi Fu, Zhangjie Zheng, Madanyeti Aersi, Jianping Peng

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引用次数: 0

摘要

目的：为了评估单次和多次荧光原位杂交（FISH）检测对上尿路癌（UTUC）的诊断准确性，我们分析了FISH在UTUC患者中的诊断效果以及它与肿瘤结节转移（TNM）分期和肿瘤分级之间的差异：纳入2011年至2021年间在我院接受治疗的UTUC患者，这些患者之前未被诊断为UTUC。根据对同一患者不同样本进行 FISH 检测的次数，将患者分为单次、两次和多次（三次或四次）FISH 检测组，并评估单次、两次和多次 FISH 检测对肌层浸润性肿瘤和高级别肿瘤的诊断效率：与单次 FISH 相比，多次和两次 FISH 诊断 UTUC 的敏感性分别从 62% 提高到 76% 和 78%。肌肉浸润性UTUC（>=pT2）的敏感性从67%上升到78%和80%，最高级别UTUC的敏感性从71%上升到79%和81%：结论：多重 FISH 提高了 UTUC 的诊断效率，有助于区分侵袭性肿瘤。

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Multiple Fluorescences in Situ Hybridization Status in Excreted Urine Improve Diagnostic Efficacy for Upper Urinary Tract Urothelial Carcinomas.

Purpose: To evaluate the diagnostic accuracy of single and multiple fluorescence in situ hybridization (FISH) tests for upper urinary tract cancer (UTUC), we analyzed the diagnostic efficacy of FISH in patients with UTUC and the difference between it and the Tumor Node Metastasis (TNM) stage and grade of the tumor.

Materials and methods: Patients treated for UTUC at our institution between 2011 and 2021 who had not been previously diagnosed with UTUC were included. Patients were divided into single, two, and multiple (three times or four times) FISH groups based on the number of FISH tests performed on different samples from the same patient, and the diagnostic efficiency of single, two, and multiple FISH tests for muscle-invasive tumors and highgrade tumors were assessed.

Results: We included a total of 207 patients with UTUC, and when compared to single FISH, the sensitivity of multiple and double FISH for the diagnosis of UTUC increased from 62% to 76% and 78%, respectively. It went from 67% to 78% and 80% for muscle-invasive UTUC (> = pT2) and from 71% to 79% and 81% for the highest- grade UTUC.

Conclusion: Multiple FISH improves the diagnostic efficacy of UTUC and helps to differentiate aggressive tumors.

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来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.