Madeleine Mant , Mindy C. Pitre , Sarah Dancer , Maria Carmela Gatto
{"title":"埃及阿斯旺附近谢赫-穆罕默德遗址的一例努比亚妇女类风湿性关节炎病例。","authors":"Madeleine Mant , Mindy C. Pitre , Sarah Dancer , Maria Carmela Gatto","doi":"10.1016/j.ijpp.2023.12.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To differentially diagnose and contextualize pathological lesions suggestive of rheumatoid arthritis.</p></div><div><h3>Materials</h3><p>The skeletal remains of a 25–30-year-old female dated to c. 1750–1550 BCE from a Nubian Pan-Grave cemetery at the site of Sheik Mohamed, near Aswan, Egypt.</p></div><div><h3>Methods</h3><p>The skeletal remains were examined macroscopically and a differential diagnosis was conducted following established protocols in the palaeopathological literature.</p></div><div><h3>Results</h3><p>Symmetrical, bilateral, erosive periarticular lesions with smooth edges were observed in multiple joints (especially in the hands and feet).</p></div><div><h3>Conclusions</h3><p>Differential diagnosis suggests this individual had rheumatoid arthritis.</p></div><div><h3>Significance</h3><p>This case suggests the presence of rheumatoid arthritis in ancient Egypt, contributing to a more finely grained understanding of the antiquity and geographical distribution of the condition.</p></div><div><h3>Limitations</h3><p>It was not possible to radiograph the skeletal remains.</p></div><div><h3>Suggestions for further research</h3><p>Researchers are encouraged to re-examine any archaeological examples of erosive polyarthropathy using current palaeopathological protocols and to explore the manifestation of rheumatoid arthritis on the African continent.</p></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"44 ","pages":"Pages 78-84"},"PeriodicalIF":1.3000,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879981723000785/pdfft?md5=3eb0ee4d417829d7b8731d5165974a55&pid=1-s2.0-S1879981723000785-main.pdf","citationCount":"0","resultStr":"{\"title\":\"A case of rheumatoid arthritis in a Nubian woman from the site of Sheikh Mohamed, near Aswan, Egypt\",\"authors\":\"Madeleine Mant , Mindy C. Pitre , Sarah Dancer , Maria Carmela Gatto\",\"doi\":\"10.1016/j.ijpp.2023.12.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To differentially diagnose and contextualize pathological lesions suggestive of rheumatoid arthritis.</p></div><div><h3>Materials</h3><p>The skeletal remains of a 25–30-year-old female dated to c. 1750–1550 BCE from a Nubian Pan-Grave cemetery at the site of Sheik Mohamed, near Aswan, Egypt.</p></div><div><h3>Methods</h3><p>The skeletal remains were examined macroscopically and a differential diagnosis was conducted following established protocols in the palaeopathological literature.</p></div><div><h3>Results</h3><p>Symmetrical, bilateral, erosive periarticular lesions with smooth edges were observed in multiple joints (especially in the hands and feet).</p></div><div><h3>Conclusions</h3><p>Differential diagnosis suggests this individual had rheumatoid arthritis.</p></div><div><h3>Significance</h3><p>This case suggests the presence of rheumatoid arthritis in ancient Egypt, contributing to a more finely grained understanding of the antiquity and geographical distribution of the condition.</p></div><div><h3>Limitations</h3><p>It was not possible to radiograph the skeletal remains.</p></div><div><h3>Suggestions for further research</h3><p>Researchers are encouraged to re-examine any archaeological examples of erosive polyarthropathy using current palaeopathological protocols and to explore the manifestation of rheumatoid arthritis on the African continent.</p></div>\",\"PeriodicalId\":48817,\"journal\":{\"name\":\"International Journal of Paleopathology\",\"volume\":\"44 \",\"pages\":\"Pages 78-84\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-01-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1879981723000785/pdfft?md5=3eb0ee4d417829d7b8731d5165974a55&pid=1-s2.0-S1879981723000785-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Paleopathology\",\"FirstCategoryId\":\"89\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1879981723000785\",\"RegionNum\":3,\"RegionCategory\":\"地球科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PALEONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Paleopathology","FirstCategoryId":"89","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1879981723000785","RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PALEONTOLOGY","Score":null,"Total":0}
A case of rheumatoid arthritis in a Nubian woman from the site of Sheikh Mohamed, near Aswan, Egypt
Objective
To differentially diagnose and contextualize pathological lesions suggestive of rheumatoid arthritis.
Materials
The skeletal remains of a 25–30-year-old female dated to c. 1750–1550 BCE from a Nubian Pan-Grave cemetery at the site of Sheik Mohamed, near Aswan, Egypt.
Methods
The skeletal remains were examined macroscopically and a differential diagnosis was conducted following established protocols in the palaeopathological literature.
Results
Symmetrical, bilateral, erosive periarticular lesions with smooth edges were observed in multiple joints (especially in the hands and feet).
Conclusions
Differential diagnosis suggests this individual had rheumatoid arthritis.
Significance
This case suggests the presence of rheumatoid arthritis in ancient Egypt, contributing to a more finely grained understanding of the antiquity and geographical distribution of the condition.
Limitations
It was not possible to radiograph the skeletal remains.
Suggestions for further research
Researchers are encouraged to re-examine any archaeological examples of erosive polyarthropathy using current palaeopathological protocols and to explore the manifestation of rheumatoid arthritis on the African continent.
期刊介绍：
Paleopathology is the study and application of methods and techniques for investigating diseases and related conditions from skeletal and soft tissue remains. The International Journal of Paleopathology (IJPP) will publish original and significant articles on human and animal (including hominids) disease, based upon the study of physical remains, including osseous, dental, and preserved soft tissues at a range of methodological levels, from direct observation to molecular, chemical, histological and radiographic analysis. Discussion of ways in which these methods can be applied to the reconstruction of health, disease and life histories in the past is central to the discipline, so the journal would also encourage papers covering interpretive and theoretical issues, and those that place the study of disease at the centre of a bioarchaeological or biocultural approach. Papers dealing with historical evidence relating to disease in the past (rather than history of medicine) will also be published. The journal will also accept significant studies that applied previously developed techniques to new materials, setting the research in the context of current debates on past human and animal health.
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