暴露于垃圾填埋场沥滤液的雄性 Wistar 大鼠脑部的神经行为缺陷、组织结构改变、副发光体神经元损伤和神经胶质激活

IF 2.7 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of chemical neuroanatomy Pub Date : 2024-01-02 DOI:10.1016/j.jchemneu.2023.102377
Usende Ifukibot Levi , Mofio M. Bintu , Osinachi Chinonyerem Daniella , Oyelowo-Abdulraheem Fatima Oyenike , Adikpe Oluwa Agbonu , Azeez Mariam Adedamola , Enefe Ndidi , Sanni Fatimah Saka , Beselia V. Gela , Smart I. Mbagwu , Edem Ekpenyong Edem , Olopade James Olukayode , Connor James
{"title":"暴露于垃圾填埋场沥滤液的雄性 Wistar 大鼠脑部的神经行为缺陷、组织结构改变、副发光体神经元损伤和神经胶质激活","authors":"Usende Ifukibot Levi ,&nbsp;Mofio M. Bintu ,&nbsp;Osinachi Chinonyerem Daniella ,&nbsp;Oyelowo-Abdulraheem Fatima Oyenike ,&nbsp;Adikpe Oluwa Agbonu ,&nbsp;Azeez Mariam Adedamola ,&nbsp;Enefe Ndidi ,&nbsp;Sanni Fatimah Saka ,&nbsp;Beselia V. Gela ,&nbsp;Smart I. Mbagwu ,&nbsp;Edem Ekpenyong Edem ,&nbsp;Olopade James Olukayode ,&nbsp;Connor James","doi":"10.1016/j.jchemneu.2023.102377","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span><span>Concerns about inappropriate disposal of waste into unsanitary municipal solid waste landfills around the world have been on the increase, and this poses a public health challenge due to leachate production. The neurotoxic effect of Gwagwalada landfill leachate (GLL) was investigated in male adult Wistar rats. Rats were exposed to a 10% concentration of GLL for 21 days. The control group received tap water for the same period of the experiment. Our results showed that </span>neurobehavior, absolute body and brain weights and brain histomorphology as well as </span>parvalbumin </span>interneurons<span><span> were severely altered, with consequent astrogliosis and microgliosis after 21 days of administrating GLL. Specifically, there was severe loss and shrinkage of </span>Purkinje cells, with their nucleus, and severe diffused vacuolations of the white matter tract of GLL-exposed rat brains. There was severe cell loss in the granular layer of the </span></span>cerebellum resulting in a reduced thickness of the layer. Also, there was severe loss of dendritic arborization of the Purkinje cells in GLL-exposed rat brains, and damage as well as reduced populations of parvalbumin-containing fast-spiking GABAergic interneurons in various regions of the brain. In conclusion, data from the present study demonstrated the detrimental effects of Gwagwalada landfill leachate on the brain which may be implicated in neuropsychological conditions.</p></div>","PeriodicalId":15324,"journal":{"name":"Journal of chemical neuroanatomy","volume":"136 ","pages":"Article 102377"},"PeriodicalIF":2.7000,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neurobehavioral deficits, histoarchitectural alterations, parvalbumin neuronal damage and glial activation in the brain of male Wistar rat exposed to Landfill leachate\",\"authors\":\"Usende Ifukibot Levi ,&nbsp;Mofio M. Bintu ,&nbsp;Osinachi Chinonyerem Daniella ,&nbsp;Oyelowo-Abdulraheem Fatima Oyenike ,&nbsp;Adikpe Oluwa Agbonu ,&nbsp;Azeez Mariam Adedamola ,&nbsp;Enefe Ndidi ,&nbsp;Sanni Fatimah Saka ,&nbsp;Beselia V. Gela ,&nbsp;Smart I. Mbagwu ,&nbsp;Edem Ekpenyong Edem ,&nbsp;Olopade James Olukayode ,&nbsp;Connor James\",\"doi\":\"10.1016/j.jchemneu.2023.102377\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span><span>Concerns about inappropriate disposal of waste into unsanitary municipal solid waste landfills around the world have been on the increase, and this poses a public health challenge due to leachate production. The neurotoxic effect of Gwagwalada landfill leachate (GLL) was investigated in male adult Wistar rats. Rats were exposed to a 10% concentration of GLL for 21 days. The control group received tap water for the same period of the experiment. Our results showed that </span>neurobehavior, absolute body and brain weights and brain histomorphology as well as </span>parvalbumin </span>interneurons<span><span> were severely altered, with consequent astrogliosis and microgliosis after 21 days of administrating GLL. Specifically, there was severe loss and shrinkage of </span>Purkinje cells, with their nucleus, and severe diffused vacuolations of the white matter tract of GLL-exposed rat brains. There was severe cell loss in the granular layer of the </span></span>cerebellum resulting in a reduced thickness of the layer. Also, there was severe loss of dendritic arborization of the Purkinje cells in GLL-exposed rat brains, and damage as well as reduced populations of parvalbumin-containing fast-spiking GABAergic interneurons in various regions of the brain. In conclusion, data from the present study demonstrated the detrimental effects of Gwagwalada landfill leachate on the brain which may be implicated in neuropsychological conditions.</p></div>\",\"PeriodicalId\":15324,\"journal\":{\"name\":\"Journal of chemical neuroanatomy\",\"volume\":\"136 \",\"pages\":\"Article 102377\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-01-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of chemical neuroanatomy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0891061823001473\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of chemical neuroanatomy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0891061823001473","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

人们对世界各地不适当地将废物丢弃到不卫生的城市固体废物填埋场的担忧与日俱增,而沥滤液的产生给公共卫生带来了挑战。我们以雄性成年 Wistar 大鼠为研究对象,调查了 Gwagwalada 垃圾填埋场沥滤液(GLL)的神经毒性效应。大鼠连续 21 天接触 10%浓度的 GLL。对照组在同一实验期间饮用自来水。我们的结果表明,服用 GLL 21 天后,大鼠的神经行为、绝对体重和脑重、脑组织形态学以及蛛网膜中间神经元都发生了严重改变,并导致星形胶质细胞和小胶质细胞病变。具体来说,暴露于 GLL 的大鼠大脑白质束中的 Purkinje 细胞及其细胞核严重缺失和萎缩,并出现严重的弥漫性空泡。小脑颗粒层细胞严重脱落,导致颗粒层厚度减少。此外,暴露于 GLL 的大鼠大脑中的浦肯野细胞树突轴化也严重丧失,大脑各区域中含有副发光素的快速尖峰 GABA 能中间神经元的数量也受损和减少。总之,本研究的数据证明了瓜瓜拉达垃圾填埋场沥滤液对大脑的有害影响,这可能与神经心理状况有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Neurobehavioral deficits, histoarchitectural alterations, parvalbumin neuronal damage and glial activation in the brain of male Wistar rat exposed to Landfill leachate

Concerns about inappropriate disposal of waste into unsanitary municipal solid waste landfills around the world have been on the increase, and this poses a public health challenge due to leachate production. The neurotoxic effect of Gwagwalada landfill leachate (GLL) was investigated in male adult Wistar rats. Rats were exposed to a 10% concentration of GLL for 21 days. The control group received tap water for the same period of the experiment. Our results showed that neurobehavior, absolute body and brain weights and brain histomorphology as well as parvalbumin interneurons were severely altered, with consequent astrogliosis and microgliosis after 21 days of administrating GLL. Specifically, there was severe loss and shrinkage of Purkinje cells, with their nucleus, and severe diffused vacuolations of the white matter tract of GLL-exposed rat brains. There was severe cell loss in the granular layer of the cerebellum resulting in a reduced thickness of the layer. Also, there was severe loss of dendritic arborization of the Purkinje cells in GLL-exposed rat brains, and damage as well as reduced populations of parvalbumin-containing fast-spiking GABAergic interneurons in various regions of the brain. In conclusion, data from the present study demonstrated the detrimental effects of Gwagwalada landfill leachate on the brain which may be implicated in neuropsychological conditions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of chemical neuroanatomy
Journal of chemical neuroanatomy 医学-神经科学
CiteScore
4.50
自引率
3.60%
发文量
87
审稿时长
62 days
期刊介绍: The Journal of Chemical Neuroanatomy publishes scientific reports relating the functional and biochemical aspects of the nervous system with its microanatomical organization. The scope of the journal concentrates on reports which combine microanatomical, biochemical, pharmacological and behavioural approaches. Papers should offer original data correlating the morphology of the nervous system (the brain and spinal cord in particular) with its biochemistry. The Journal of Chemical Neuroanatomy is particularly interested in publishing important studies performed with up-to-date methodology utilizing sensitive chemical microassays, hybridoma technology, immunocytochemistry, in situ hybridization and receptor radioautography, to name a few examples. The Journal of Chemical Neuroanatomy is the natural vehicle for integrated studies utilizing these approaches. The articles will be selected by the editorial board and invited reviewers on the basis of their excellence and potential contribution to this field of neurosciences. Both in vivo and in vitro integrated studies in chemical neuroanatomy are appropriate subjects of interest to the journal. These studies should relate only to vertebrate species with particular emphasis on the mammalian and primate nervous systems.
期刊最新文献
Brain Mechanisms - An evolving perspective on the future of neuroscience. Editorial Board Retraction notice to “Astrocyte response to melatonin treatment in rats under high-carbohydrate high-fat diet” [J. Chem. Neuroanat. 136 (2024) 102389] Retraction notice to “Coenzyme Q10 attenuates neurodegeneration in the cerebellum induced by chronic exposure to tramadol” [J. Chem. Neuroanat. 135 (2024) 102367] Retraction notice to “Maternal diabetes-induced alterations in the expression of brain-derived neurotrophic factor in the developing rat hippocampus” [J. Chem. Neuroanat. 114(2021) 101946]
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1