Journal of chemical neuroanatomy最新文献

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Brain Mechanisms - An evolving perspective on the future of neuroscience. 社论：大脑机制--神经科学未来不断发展的视角。

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy

Pub Date : 2024-11-13 DOI: 10.1016/j.jchemneu.2024.102482

Goran Šimić, Gail M Rodney

引用次数: 0

Retraction notice to “Astrocyte response to melatonin treatment in rats under high-carbohydrate high-fat diet” [J. Chem. Neuroanat. 136 (2024) 102389] 高碳水化合物高脂肪饮食条件下大鼠星形胶质细胞对褪黑素处理的反应"[J. Chem. Neuroanat.

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy

Pub Date : 2024-10-15 DOI: 10.1016/j.jchemneu.2024.102474

Davood Dorranipour , Fahimeh Pourjafari , Reza Malekpour-Afshar , Mohsen Basiri , Mehran Hosseini

引用次数: 0

Retraction notice to “Maternal diabetes-induced alterations in the expression of brain-derived neurotrophic factor in the developing rat hippocampus” [J. Chem. Neuroanat. 114(2021) 101946] 母体糖尿病诱导的发育中大鼠海马脑源性神经营养因子表达的改变"[J. Chem. Neuroanat.

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy

Pub Date : 2024-10-11 DOI: 10.1016/j.jchemneu.2024.102469

Reza Sardar , Javad Hami , Mansoureh Soleimani , Mohammad-Taghi Joghataei , Reza Shirazi , Fereshteh Golab , Zeinab Namjoo , Zahra Zandieh

引用次数: 0

Retraction notice to “Coenzyme Q10 attenuates neurodegeneration in the cerebellum induced by chronic exposure to tramadol” [J. Chem. Neuroanat. 135 (2024) 102367] 关于 "辅酶Q10可减轻长期暴露于曲马多引起的小脑神经退行性变 "的撤稿通知[J. Chem. Neuroanat.

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy

Pub Date : 2024-10-11 DOI: 10.1016/j.jchemneu.2024.102472

Majid Keyhanifard , Roghayeh Javan , Reza Ataee Disfani , Maryam Bahrami , Mohamad Sedigh Mirzaie , Saeid Taghiloo , Hossein Mokhtari , Davood Nasiry , Zahra Sadrzadeh Aghajani , Mahdi Shooraj

引用次数: 0

Retraction notice to “Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats” [J. Chem. Neuroanat. 135 (2024) 102365] 关于 "Phyllanthus amarus 的叶水溶液提取物在百草枯诱导的帕金森病样模型中保护成年 Wistar 大鼠免受氧化应激和多巴胺能神经元的误触发 "的撤稿通知 [J. Chem. Neuroanat. 135 (2024) 102365]。

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy

Pub Date : 2024-10-11 DOI: 10.1016/j.jchemneu.2024.102470

Felix U. Enemali, Kingsley Afoke Iteire, Raphael E. Uweigho, Ogunberi Blessing, Gbayisomore Tolulope Judah

引用次数: 0

Retraction notice to “Cladribine induces apoptosis, neuroinflammation, mitochondrial oxidative stress, tau phosphorylation and Aβ (1–42) pathway in the hippocampus: An in vivo approach” [J. Chem. Neuroanat. 133 (2023) 102340] 克拉利宾诱导海马细胞凋亡、神经炎症、线粒体氧化应激、tau 磷酸化和 Aβ (1-42) 通路：体内方法"[J. Chem. Neuroanat.

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy

Pub Date : 2024-10-10 DOI: 10.1016/j.jchemneu.2024.102471

Khadga Raj Aran , G.D. Gupta , Shamsher Singh

引用次数: 0

Chronic pramipexole and rasagiline treatment enhances dendritic spine structural neuroplasticity in striatal and prefrontal cortex neurons of rats with bilateral intrastriatal 6-hydroxydopamine lesions 慢性普拉克索和拉沙吉林治疗可增强双侧椎管内6-羟基多巴胺损伤大鼠纹状体和前额叶皮层神经元树突棘结构的神经可塑性。

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy

Pub Date : 2024-10-09 DOI: 10.1016/j.jchemneu.2024.102468

Alfonso Boyzo Montes de Oca , Hiram Tendilla-Beltrán , María E. Bringas , Gonzalo Flores , Jorge Aceves

Parkinson's disease manifests as neurological alterations within dendritic spines in the striatal and neocortical brain regions, where their functionality closely correlates with morphology. However, the impact of current pharmacotherapy on dendritic spine neuroplasticity, crucial for novel drug development in neurological and psychiatric disorders, remains unclear. This study investigated the effects of 6-OHDA intrastriatal bilateral lesions in male adult rats on behavior and dendritic spine neuroplasticity in striatal and cortical neurons. Furthermore, it evaluated the influence of chronic co-administration of pramipexole (PPX), a D3 receptor agonist, and rasagiline (Ras), a selective MAO-B inhibitor, on these alterations. Lesioned animals exhibited impaired balance behavior, with no improvement following PPX-Ras treatment. The 6-OHDA lesion decreased dendritic spine density in caudate putamen (CPU) spiny projection neurons (SPNs), a change unaffected by treatment, though PPX-Ras increased mushroom spines and reduced stubby spines in these neurons. In nucleus accumbens (NAcc) SPNs and prefrontal cortex layer 3 (PFC-3) pyramidal cells, dendritic spine density remained unaltered, but PPX-Ras decreased mushroom spines and increased bifurcated spines in the NAcc, while increasing mushroom spines and decreasing stubby spines in PFC-3 in lesioned rats. These findings emphasize the importance of dendritic spines as promising targets for innovative pharmacotherapies for Parkinson’s disease.

帕金森病表现为纹状体和新皮质脑区树突棘的神经改变，其功能与形态密切相关。然而，目前的药物治疗对树突棘神经可塑性的影响仍不清楚，而树突棘神经可塑性对神经和精神疾病的新药开发至关重要。本研究调查了雄性成年大鼠6-OHDA椎体内双侧损伤对纹状体和皮质神经元行为和树突棘神经可塑性的影响。此外，该研究还评估了长期联合使用 D3 受体激动剂普拉克索（PPX）和选择性 MAO-B 抑制剂拉沙吉兰（Ras）对这些改变的影响。病变动物表现出平衡行为受损，PPX-Ras治疗后未见改善。6-OHDA损伤降低了尾状体普门（CPU）棘投射神经元（SPNs）的树突棘密度，这一变化不受治疗的影响，但PPX-Ras增加了这些神经元的蘑菇棘，减少了粗壮棘。在病变大鼠的伏隔核（NAcc）SPNs和前额叶皮层第3层（PFC-3）锥体细胞中，树突棘密度保持不变，但在NAcc中，PPX-Ras会减少蘑菇状棘突，增加分叉棘突，而在PFC-3中，蘑菇状棘突会增加，矮小棘突会减少。这些发现强调了树突棘作为帕金森病创新药物治疗靶点的重要性。

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引用次数: 0

Retraction notice to “Gelatin/polyethylene glycol-loaded magnesium hydroxide nanocomposite to attenuate acetylcholinesterase, neurotoxicity, and activation of GPR55 protein in rat models of Alzheimer's disease” [J. Chem. Neuroanat. 133 (2023) 102337] 明胶/聚乙二醇负载氢氧化镁纳米复合材料在阿尔茨海默病大鼠模型中减轻乙酰胆碱酯酶、神经毒性和 GPR55 蛋白激活》的撤稿通知[J. Chem. Neuroanat.

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy

Pub Date : 2024-07-30 DOI: 10.1016/j.jchemneu.2024.102448

Manickam Rajkumar , Sundarraj Navaneethakrishnan , Sundarapandian Muthukumar , Ramasundaram Thangaraj , Magudeeswaran Sivanandam , Karuppaiya Vimala , Soundarapandian Kannan

引用次数: 0

A combined MRI, histological and immunohistochemical rendering of the rhesus macaque locus coeruleus (LC) enables the differentiation of three distinct LC subcompartments 结合磁共振成像、组织学和免疫组织化学方法对猕猴的脑室（LC）进行渲染，可以区分三个不同的脑室亚区。

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy

Pub Date : 2024-07-29 DOI: 10.1016/j.jchemneu.2024.102449

Irina T. Sinakevitch , Kelsey E. McDermott , Daniel T. Gray , Carol A. Barnes

Locus coeruleus (LC) neurons send their noradrenergic axons across multiple brain regions, including neocortex, subcortical regions, and spinal cord. Many aspects of cognition are known to be dependent on the noradrenergic system, and it has been suggested that dysfunction in this system may play central roles in cognitive decline associated with both normative aging and neurodegenerative disease. While basic anatomical and biochemical features of the LC have been examined in many species, detailed characterizations of the structure and function of the LC across the lifespan are not currently available. This includes the rhesus macaque, which is an important model of human brain function because of their striking similarities in brain architecture and behavioral capacities. In the present study, we describe a method to combine structural MRI, Nissl, and immunofluorescent histology from individual monkeys to reconstruct, in 3 dimensions, the entire macaque LC nucleus. Using these combined methods, a standardized volume of the LC was determined, and high-resolution confocal images of tyrosine hydroxylase-positive neurons were mapped into this volume. This detailed representation of the LC allows definitions to be proposed for three distinct subnuclei, including a medial region and a lateral region (based on location with respect to the central gray, inside or outside, respectively), and a compact region (defined by densely packed neurons within the medial compartment). This enabled the volume to be estimated and cell density to be calculated independently in each LC subnucleus for the first time. This combination of methods should allow precise characterization of the LC and has the potential to do the same for other nuclei with distinct molecular features.

神经元的去甲肾上腺素能轴突遍布多个脑区，包括新皮层、皮层下区和脊髓。众所周知，认知的许多方面都依赖于去甲肾上腺素能系统，有人认为，该系统的功能障碍可能在与正常衰老和神经退行性疾病相关的认知能力下降中起着核心作用。虽然许多物种的低密度脂蛋白胆固醇的基本解剖和生化特征已得到研究，但目前还没有关于低密度脂蛋白胆固醇在整个生命周期中的结构和功能的详细描述。这其中就包括猕猴，猕猴是人类大脑功能的重要模型，因为它们在大脑结构和行为能力方面有着惊人的相似之处。在本研究中，我们介绍了一种结合结构磁共振成像、Nissl 和免疫荧光组织学的方法，从单个猴子的三维角度重建整个猕猴 LC 核。利用这些综合方法，确定了 LC 的标准化体积，并将酪氨酸羟化酶阳性神经元的高分辨率共聚焦图像映射到该体积中。LC 的这一详细表征为三个不同的亚核提出了定义，包括一个内侧区和一个外侧区（分别基于相对于中央灰质的内部或外部位置），以及一个密集区（由内侧区内密集的神经元定义）。这样就能首次独立估算每个 LC 亚核的体积并计算细胞密度。这种方法的结合应能精确描述 LC 的特征，并有可能对具有独特分子特征的其他核进行同样的分析。

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引用次数: 0

Retraction notice to aerobic exercise training reduces deep-frying oil-induced apoptosis of hippocampal tissue by reducing oxidative stress in male rats [J. Chem. Neuroanat. 133 (2023) 102328] 撤稿通知：有氧运动训练可通过降低氧化应激减少油炸诱导的雄性大鼠海马组织凋亡[J. Chem. Neuroanat. 133 (2023) 102328]。

IF 2.7 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of chemical neuroanatomy

Pub Date : 2024-07-25 DOI: 10.1016/j.jchemneu.2024.102447

Sina Nikbin , Gita Fardad , Sara Yazdi , Marzieh Hosseini Bahman , Parvaneh Ettefagh , Fatemeh Khalegi , Mino Molaei , Kamal Azizbeigi , Myriam Guerra-Balic , Joel Montan , Mehdi Zargani , Mohammad Ali Azarbayjani

引用次数: 0

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