Elhassan Mahmoud, Abdalla Moustafa Elsayed, Muhammad Zain Kaleem, Hamad A Alkorbi, Amgad M Elshoeibi, Tawanda Chivese, Susu M Zughaier
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引用次数: 0
摘要
本研究利用 2013-2018 年三次美国国家健康与营养调查(NHANES)调查周期,采用单核细胞百分比与高密度脂蛋白胆固醇比值(MHR)探讨邻苯二甲酸盐与总维生素 D 水平之间的关系,以及邻苯二甲酸盐暴露与亚临床炎症之间的联系。本研究为横断面研究,利用随机抽取的NHANES参与者的一次性尿样来评估邻苯二甲酸酯代谢物。研究发现,维生素 D 与所有邻苯二甲酸二(2-乙基己基)酯(DEHP)代谢物之间存在反比关系。DEHP 代谢物的摩尔总和与维生素 D 成反比(β -2.329;95% CI -3.937,-0.720)。邻苯二甲酸单羧壬酯与维生素 D 呈反比关系(β -0.0278;95% CI -0.0527,-0.00298)。邻苯二甲酸单羧辛酯与维生素 D 之间也存在类似的关系(β -0.0160;95% CI -0.0242,-0.00775)。邻苯二甲酸酯代谢物与 MHR 之间没有关联。分层分析表明,邻苯二甲酸酯代谢物与 MHR 之间的关系可能因维生素 D 状态而异。
Impact of phthalate metabolites on vitamin D levels and subclinical inflammation: national health and nutrition examination survey, 2013-2018.
This study explores the association between phthalates and total vitamin D levels and the link between phthalates exposure and subclinical inflammation using monocyte percentage to high-density lipoprotein cholesterol ratio (MHR), utilizing three National Health and Nutrition Examination Survey (NHANES) survey cycles 2013-2018. This study is cross-sectional, utilizing one-time urine samples from randomly selected NHANES participants to assess phthalate metabolites. An inverse association between vitamin D and all Di(2-ethylhexyl) phthalate (DEHP) metabolites was found. The molar sum of DEHP metabolites was inversely associated with vitamin D (β -2.329; 95% CI -3.937,-0.720). An inverse association was observed between monocarboxynonyl phthalate and vitamin D (β -0.0278; 95% CI -0.0527,-0.00298). A similar relationship was found between monocarboxyoctyl phthalate and vitamin D (β -0.0160; 95% CI -0.0242,-0.00775). There was no association between phthalate metabolites and MHR. Stratified analysis showed that the association between phthalate metabolites and MHR may vary according to vitamin D status.
期刊介绍:
International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.