旅行归来数年后出现球孢子菌病

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Medical Mycology Case Reports Pub Date : 2023-12-30 DOI:10.1016/j.mmcr.2023.100623

Koos Korsten , Josje Altenburg , Marieke Gittelbauer , Peter van Hengel , Rogier Jansen , Karin van Dijk

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摘要

一名 26 岁的荷兰男子在 2017 年前往加利福尼亚州旅行后，于 2020 年因持续咳嗽和气短前来就诊。放射学检查显示他的右上叶有囊性支气管扩张和支气管周围合并症。2021 年 8 月的实验室检查显示，总 IgE、特异性曲霉菌 IgE、嗜酸性粒细胞增多，BAL 培养显示球孢子菌/posadasii 阳性。因怀疑患有过敏性支气管肺曲霉菌病而接受伊曲康唑治疗 6 周后，症状持续存在，呼吸道培养仍呈阳性。使用氟康唑治疗 6 个月后，感染痊愈。(最多 75 个字）

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Coccidioidomycosis presenting years after returning from travel

After having traveled to California in 2017, a 26-year old Dutch man presented in 2020 with persisting cough and shortness of breath. Radiology showed cystic bronchiectasis with peri-bronchial consolidation in his right upper lobe. Laboratory studies in August 2021 showed an increased total IgE, specific Aspergillus IgE, eosinophilia and positive BAL culture for Coccidioides immitis/posadasii. After 6 weeks of itraconazole treatment for suspected allergic bronchopulmonary aspergillosis, symptoms persisted and respiratory cultures remained positive. The infection was cleared after a 6-month course of fluconazole. (max 75 words)

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