Pub Date : 2025-12-11DOI: 10.1016/j.mmcr.2025.100757
Neema Pithia , Margie Morgan , Thea Tagliaferro , Priya R. Soni
Extremely preterm neonates are at heightened risk for invasive fungal infections. We report a fatal case of Aspergillus flavus infection in a 25-week infant, outlining the clinical course, antifungal treatment, and challenges in management. This case highlights the need for early recognition, rapid biopsy and aggressive therapy in vulnerable neonates.
{"title":"An invasive Aspergillus flavus infection in an extremely preterm neonate: a case report","authors":"Neema Pithia , Margie Morgan , Thea Tagliaferro , Priya R. Soni","doi":"10.1016/j.mmcr.2025.100757","DOIUrl":"10.1016/j.mmcr.2025.100757","url":null,"abstract":"<div><div>Extremely preterm neonates are at heightened risk for invasive fungal infections. We report a fatal case of <em>Aspergillus flavus</em> infection in a 25-week infant, outlining the clinical course, antifungal treatment, and challenges in management. This case highlights the need for early recognition, rapid biopsy and aggressive therapy in vulnerable neonates.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100757"},"PeriodicalIF":1.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sporotrichosis is a neglected fungal disease, affecting mammals. Here, a feline patient presented a small ulcerated lesion. Short treatment by itraconazole resulted in clinical cure. The isolate was identified as Sporothrix brunneoviolacea by sequencing. Despite proper growth, antifungal susceptibility testing by microbroth dilution could not be performed due to a lack of growth. This is the first report of sporotrichosis by S. brunneoviolacea, which was originally classified as an environmental and non-pathogenic species.
{"title":"First report of sporotrichosis by Sporothrix brunneoviolacea","authors":"Mariana Rodrgiues Trápaga , Bram Spruijtenburg , Bruna Jacomel , Jéssica Estefânia Dávila Hidalgo , Karine Ortiz Sanchotene , Fabiana Fedatto Bernardon , Bruna Muradás Esperon , Vanice Rodrigues Poester , Theun de Groot , Eelco F.J. Meijer , Melissa Orzechowski Xavier","doi":"10.1016/j.mmcr.2025.100756","DOIUrl":"10.1016/j.mmcr.2025.100756","url":null,"abstract":"<div><div>Sporotrichosis is a neglected fungal disease, affecting mammals. Here, a feline patient presented a small ulcerated lesion. Short treatment by itraconazole resulted in clinical cure. The isolate was identified as <em>Sporothrix brunneoviolacea</em> by sequencing. Despite proper growth, antifungal susceptibility testing by microbroth dilution could not be performed due to a lack of growth. This is the first report of sporotrichosis by <em>S. brunneoviolacea</em>, which was originally classified as an environmental and non-pathogenic species.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100756"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.mmcr.2025.100754
Beatrice Z. Sim, Amanda Seidenfeld, Jessica Focht, Jennifer Saullo, Manuela Carugati
Blastomyces dermatitidis, a dimorphic fungal infection endemic to North America, is typically associated with pulmonary disease, but may also disseminate. We report the case of a 54-year-old female liver transplant recipient who developed blastomycosis with cutaneous and likely pulmonary involvement. She was successfully treated with posaconazole, an alternative to itraconazole with a favorable safety and interaction profile, demonstrating the therapeutic potential of posaconazole as a primary agent for blastomycosis in transplant recipients.
{"title":"Disseminated cutaneous blastomycosis in a liver transplant recipient: A case report","authors":"Beatrice Z. Sim, Amanda Seidenfeld, Jessica Focht, Jennifer Saullo, Manuela Carugati","doi":"10.1016/j.mmcr.2025.100754","DOIUrl":"10.1016/j.mmcr.2025.100754","url":null,"abstract":"<div><div><em>Blastomyces dermatitidis,</em> a dimorphic fungal infection endemic to North America, is typically associated with pulmonary disease, but may also disseminate. We report the case of a 54-year-old female liver transplant recipient who developed blastomycosis with cutaneous and likely pulmonary involvement. She was successfully treated with posaconazole, an alternative to itraconazole with a favorable safety and interaction profile, demonstrating the therapeutic potential of posaconazole as a primary agent for blastomycosis in transplant recipients.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100754"},"PeriodicalIF":1.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.mmcr.2025.100752
Hongzhen Shu , Xiaofeng Li , Yuying Chen , Weihong Wang
Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis (DH) is rare and often misdiagnosed, especially in non-endemic areas. We present a case of a 70-year-old Chinese man who was admitted with fever, nausea, and vomiting, initially misdiagnosed with pulmonary tuberculosis. The use of metagenomic next-generation sequencing (mNGS) played a crucial role in the early and accurate diagnosis, highlighting its potential as a valuable diagnostic tool for rare infections.
{"title":"Hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in an HIV-negative patient: A case of misdiagnosis","authors":"Hongzhen Shu , Xiaofeng Li , Yuying Chen , Weihong Wang","doi":"10.1016/j.mmcr.2025.100752","DOIUrl":"10.1016/j.mmcr.2025.100752","url":null,"abstract":"<div><div>Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis (DH) is rare and often misdiagnosed, especially in non-endemic areas. We present a case of a 70-year-old Chinese man who was admitted with fever, nausea, and vomiting, initially misdiagnosed with pulmonary tuberculosis. The use of metagenomic next-generation sequencing (mNGS) played a crucial role in the early and accurate diagnosis, highlighting its potential as a valuable diagnostic tool for rare infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100752"},"PeriodicalIF":1.3,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.mmcr.2025.100750
Frantzeska Frantzeskaki , Nikolas Stratopoulos , Sandra Elise van der Griend , Ioannis Renieris , Kostantinos Thomas , Iraklis Tsagkaris
Fusariosis is a severe fungal infection associated with high mortality rates and an increasing incidence. However, its treatment remains challenging due to the frequent resistance of Fusarium species to conventional antifungal therapies. Here, we describe a case of an immunocompetent patient with invasive disseminated fusariosis with multifocal abscess formation after major traumatic injury. We report a significant clinical improvement with clinically relevant reduction of abscesses without major treatment toxicity after treatment with fosmanogepix.
{"title":"Successful treatment of a resistant invasive disseminated Fusarium infection in an immunocompetent patient","authors":"Frantzeska Frantzeskaki , Nikolas Stratopoulos , Sandra Elise van der Griend , Ioannis Renieris , Kostantinos Thomas , Iraklis Tsagkaris","doi":"10.1016/j.mmcr.2025.100750","DOIUrl":"10.1016/j.mmcr.2025.100750","url":null,"abstract":"<div><div>Fusariosis is a severe fungal infection associated with high mortality rates and an increasing incidence. However, its treatment remains challenging due to the frequent resistance of Fusarium species to conventional antifungal therapies. Here, we describe a case of an immunocompetent patient with invasive disseminated fusariosis with multifocal abscess formation after major traumatic injury. We report a significant clinical improvement with clinically relevant reduction of abscesses without major treatment toxicity after treatment with fosmanogepix.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100750"},"PeriodicalIF":1.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.mmcr.2025.100751
Jordan K. Mah , John I. Hogan , Sonya Kothadia , Jeffrey E. Keenan , Johnathan Berger , Manuela Carugati
A cluster of Aspergillus fumigatus donor-derived infections (DDI) was rapidly diagnosed using plasma metagenomic next-generation sequencing (mNGS) among solid organ transplant recipients. The heart recipient, experiencing marginal hemodynamics, underwent an endomyocardial biopsy, which was concerning for a fungal infection on histopathology. Plasma mNGS was performed, identifying A. fumigatus two days prior to conventional diagnostics. This timely diagnosis enabled prompt nephrectomies in the kidney recipients, who survived. This report represents the first published use of mNGS in the diagnosis of Aspergillus fumigatus DDI, highlighting the utility of this novel, underutilized assay for early diagnosis of donor-derived infections.
{"title":"Application of plasma cell-free metagenomic next-generation sequencing for the identification of Aspergillus fumigatus donor-derived infections among solid organ transplant recipients","authors":"Jordan K. Mah , John I. Hogan , Sonya Kothadia , Jeffrey E. Keenan , Johnathan Berger , Manuela Carugati","doi":"10.1016/j.mmcr.2025.100751","DOIUrl":"10.1016/j.mmcr.2025.100751","url":null,"abstract":"<div><div>A cluster of Aspergillus fumigatus donor-derived infections (DDI) was rapidly diagnosed using plasma metagenomic next-generation sequencing (mNGS) among solid organ transplant recipients. The heart recipient, experiencing marginal hemodynamics, underwent an endomyocardial biopsy, which was concerning for a fungal infection on histopathology. Plasma mNGS was performed, identifying A. fumigatus two days prior to conventional diagnostics. This timely diagnosis enabled prompt nephrectomies in the kidney recipients, who survived. This report represents the first published use of mNGS in the diagnosis of Aspergillus fumigatus DDI, highlighting the utility of this novel, underutilized assay for early diagnosis of donor-derived infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100751"},"PeriodicalIF":1.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-07DOI: 10.1016/j.mmcr.2025.100749
Carla Rey-Suarez , Paula Caramazana-Lopez , Iván Fernández-Castro , Helena Esteban-Cartelle , Daniel Navarro-de la Cruz , Elena Losada-Arias
Invasive fungal sinusitis by Scedosporium spp. is a rare but severe infection in immunocompromised patients. We report an 80-year-old woman with poorly controlled diabetes and chronic corticosteroid use who presented with headache, hearing loss, and facial paralysis. She was ultimately diagnosed with sphenoid sinusitis due to Scedosporium boydii. Management required surgical debridement and prolonged antifungal therapy complicated by drug-induced liver injury. Early diagnosis and multidisciplinary treatment are crucial to improve prognosis in these complex infections.
{"title":"Invasive fungal sinusitis by Scedosporium boydii in an immunocompromised patient. A case report","authors":"Carla Rey-Suarez , Paula Caramazana-Lopez , Iván Fernández-Castro , Helena Esteban-Cartelle , Daniel Navarro-de la Cruz , Elena Losada-Arias","doi":"10.1016/j.mmcr.2025.100749","DOIUrl":"10.1016/j.mmcr.2025.100749","url":null,"abstract":"<div><div>Invasive fungal sinusitis by <em>Scedosporium</em> spp. is a rare but severe infection in immunocompromised patients. We report an 80-year-old woman with poorly controlled diabetes and chronic corticosteroid use who presented with headache, hearing loss, and facial paralysis. She was ultimately diagnosed with sphenoid sinusitis due to <em>Scedosporium boydii</em>. Management required surgical debridement and prolonged antifungal therapy complicated by drug-induced liver injury. Early diagnosis and multidisciplinary treatment are crucial to improve prognosis in these complex infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100749"},"PeriodicalIF":1.3,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.mmcr.2025.100748
Ailén Dumont-Viollaz , Belén Rivera Gómez-Barris , Gabriel Velozo , Leslye Camila del Río , Byron Guzmán-Marín , Pamela Thomson
In November 2024, a female Chilean Chihuahua presented with a limb lesion that did not heal after spaying. The diagnosis indicated Aureobasidium pullulans infection. The antifungigram showed susceptibility to itraconazole, treatment with this drug together with bilateral amputation resulted in a complete recovery. The phylogenetic tree of the ITS gene showed differences with other sequences of the same species from animals and lichens. This case highlights this environmental fungus as a potential pathogen in dogs.
{"title":"First case of Aureobasidium pullulans in a dog after sterilization surgery in Chile","authors":"Ailén Dumont-Viollaz , Belén Rivera Gómez-Barris , Gabriel Velozo , Leslye Camila del Río , Byron Guzmán-Marín , Pamela Thomson","doi":"10.1016/j.mmcr.2025.100748","DOIUrl":"10.1016/j.mmcr.2025.100748","url":null,"abstract":"<div><div>In November 2024, a female Chilean Chihuahua presented with a limb lesion that did not heal after spaying. The diagnosis indicated <em>Aureobasidium pullulans</em> infection. The antifungigram showed susceptibility to itraconazole, treatment with this drug together with bilateral amputation resulted in a complete recovery. The phylogenetic tree of the ITS gene showed differences with other sequences of the same species from animals and lichens. This case highlights this environmental fungus as a potential pathogen in dogs.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100748"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To our knowledge, this is the first report of Prototheca sp. isolated from the digestive tract of a dolphin. A captive-born female bottlenose dolphin (Tursiops truncatus) weighing 165 kg that was housed at Enoshima Aquarium presented with a slightly elevated body temperature and candida-like yeasts in stomach fluid and feces. Gastroscopy revealed cobblestone-like thickening of the mucosa with a few ulcers in the forestomach. Prototheca bovis was isolated from the biopsy specimen of the lesion.
{"title":"First isolation of Prototheca bovis from a bottlenose dolphin (Tursiops truncatus)","authors":"Chika Shirakata , Kanon Tsurumi , Koichi Makimura , Rui Kano","doi":"10.1016/j.mmcr.2025.100746","DOIUrl":"10.1016/j.mmcr.2025.100746","url":null,"abstract":"<div><div>To our knowledge, this is the first report of <em>Prototheca</em> sp. isolated from the digestive tract of a dolphin. A captive-born female bottlenose dolphin (<em>Tursiops truncatus</em>) weighing 165 kg that was housed at Enoshima Aquarium presented with a slightly elevated body temperature and candida-like yeasts in stomach fluid and feces. Gastroscopy revealed cobblestone-like thickening of the mucosa with a few ulcers in the forestomach. <em>Prototheca bovis</em> was isolated from the biopsy specimen of the lesion.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100746"},"PeriodicalIF":1.3,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-21DOI: 10.1016/j.mmcr.2025.100747
Rajeev Soman, Sanraksha Mayya, Sushrut Ganpule, Geethu Joe
Viral associated pulmonary aspergillosis (VAPA) is increasingly being recognized by clinicians. However, the same patient developing VAPA after two separate viral respiratory illness appears to be rare. We describe a patient who developed influenza associated invasive aspergillosis (IAPA) which resolved completely with treatment. A second episode of VAPA developed after one year following human rhinovirus/enterovirus with a nodular infiltrate at a different location in the lungs as compared to earlier. Neither episode required ICU admission and both episodes were treated successfully.
{"title":"VAPA strikes the patient again!","authors":"Rajeev Soman, Sanraksha Mayya, Sushrut Ganpule, Geethu Joe","doi":"10.1016/j.mmcr.2025.100747","DOIUrl":"10.1016/j.mmcr.2025.100747","url":null,"abstract":"<div><div>Viral associated pulmonary aspergillosis (VAPA) is increasingly being recognized by clinicians. However, the same patient developing VAPA after two separate viral respiratory illness appears to be rare. We describe a patient who developed influenza associated invasive aspergillosis (IAPA) which resolved completely with treatment. A second episode of VAPA developed after one year following human rhinovirus/enterovirus with a nodular infiltrate at a different location in the lungs as compared to earlier. Neither episode required ICU admission and both episodes were treated successfully.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100747"},"PeriodicalIF":1.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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