患有特应性皮炎的学龄前儿童中与食物过敏相关的因素,以及特应性皮炎的缓解情况。

IF 2.3 4区 医学 Q3 ALLERGY Asian Pacific journal of allergy and immunology Pub Date : 2024-01-06 DOI:10.12932/AP-080623-1627
Supaluk Tangvalelerd, Kantima Kanchanapoomi, Prapasri Kulalert, Punchama Pacharn, Orathai Jirapongsananuruk, Nualanong Visitsunthorn, Rattanavalai Nitiyarom, Wanee Wisuthsarewong, Witchaya Srisuwatchari
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引用次数: 0

摘要

背景:据报道,三分之一患有中重度特应性皮炎(AD)的儿童会对食物过敏:据报道,三分之一患有中度至重度特应性皮炎(AD)的儿童对食物过敏(FA):在患有特应性皮炎(AD)的学龄前儿童中找出与食物过敏相关的因素,并比较患有和未患有特应性皮炎(AD)的学龄前儿童对食物过敏的缓解情况:方法:2022年,在泰国曼谷的Siriraj医院进行了一项横断面研究,采用数据库登记和问卷调查的方法,对医生诊断的6岁以下AD儿童进行了登记:结果:共纳入110名儿童(60.9%为男性,年龄中位数为2.3岁)。其中分别有53名和57名儿童患有伴有和不伴有FA的AD。在无FA的AD患儿中,分别有43.9%和26.3%的患儿极早发AD(≤3个月),在有FA的AD患儿中,分别有35.8%和45.3%的患儿中度至重度AD。最常报告的食品添加剂是鸡蛋、牛奶和小麦。中度至重度 AD 发病与 FA 有显著相关性(aOR:2.50;p = 0.037)。31名患者(28.2%)在5岁时AD症状完全消失。其中,19 人患有无 FA 的 AD,12 人患有有 FA 的 AD(p = 0.213)。无FA组和有FA组的AD缓解中位年龄分别为18个月和22.5个月。在对注意力缺失症的发病时间和严重程度进行调整后,患有注意力缺失症的儿童的注意力缺失症缓解时间有明显延长的趋势(aHR:0.46,p = 0.050):结论:与无FA的AD儿童相比,有FA的学龄前AD儿童在AD发病时AD严重程度明显更高,AD缓解持续时间更长。
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Factor associated with food allergy among preschool children with atopic dermatitis, and resolution of atopic dermatitis.

Background: Food allergy (FA) has been reported in one-third of children with moderate-to-severe atopic dermatitis (AD).

Objective: To identify factor associated with food allergy among preschool children with AD, and to compare AD resolution between preschool children with and without FA.

Methods: A cross-sectional study using database registry and questionnaire interview was conducted at Siriraj Hospital(Bangkok, Thailand) during 2022, and physician-diagnosed AD children aged ≤ 6 years were enrolled.

Results: A total of 110 children (60.9% male, median age: 2.3 years) were included. Of those, 53 and 57 children had AD with and without FA, respectively. Very early-onset AD (≤ 3 months) and moderate-to-severe AD at onset were reported in 43.9% and 26.3% of AD without FA, and in 35.8% and 45.3% of AD with FA, respectively. The most commonly reported FAs were hen's egg, cow's milk, and wheat. Moderate-to-severe AD at onset was found significant associated with FA (aOR: 2.50; p = 0.037). Thirty-one (28.2%) patients experienced completed resolution of AD by 5 years of age. Of those, 19 had AD without FA, and 12 had AD with FA (p = 0.213). The median age at AD resolution was 18 months and 22.5 months in the without and with FA groups, respectively. AD with FA showed a strong trend toward a significantly longer duration to achieving AD resolution after adjusting for onset and severity of AD (aHR: 0.46, p = 0.050).

Conclusion: Preschool AD children with FA were found to have significantly greater AD severity at AD onset and a longer duration to AD resolution compared to AD children without FA.

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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
74
审稿时长
>12 weeks
期刊介绍: The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.
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