Jiansheng Yang, Di Wu, Liling Zeng, Minzhi Zhong, Tianshan Liang, Honghong Jiang, Qiang Liu, Yanhua Wu, Hui Li
{"title":"硝酸甘油或皮质扩张抑制诱导的偏头痛大鼠模型的脑组织代谢组学研究","authors":"Jiansheng Yang, Di Wu, Liling Zeng, Minzhi Zhong, Tianshan Liang, Honghong Jiang, Qiang Liu, Yanhua Wu, Hui Li","doi":"10.1166/mex.2024.2579","DOIUrl":null,"url":null,"abstract":"This study analyzes the differences in potential biomarkers of migraine models constructed by two commonly used modeling methods through metabolomics research. Migraine models were constructed by nitroglycerin (NTG) induction or mechanical stimulus-induced cortical spreading depression (CSD) in rats. Multivariate analysis was used for metabolomic analysis. Compared with control group, NTG migraine group had 1 different metabolite up-regulated and 14 down-regulated. Compared with NTG migraine group, 13 differential metabolites in the CSD migraine model group were up-regulated and 12 were down-regulated. Both nitroglycerin-induced and mechanical stimulation-induced CSD can construct migraine rat models, and the biomarkers of the two models are different.","PeriodicalId":18318,"journal":{"name":"Materials Express","volume":"112 7","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Metabonomics of brain tissue in migraine rat model induced by nitroglycerin or cortical spreading depression\",\"authors\":\"Jiansheng Yang, Di Wu, Liling Zeng, Minzhi Zhong, Tianshan Liang, Honghong Jiang, Qiang Liu, Yanhua Wu, Hui Li\",\"doi\":\"10.1166/mex.2024.2579\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study analyzes the differences in potential biomarkers of migraine models constructed by two commonly used modeling methods through metabolomics research. Migraine models were constructed by nitroglycerin (NTG) induction or mechanical stimulus-induced cortical spreading depression (CSD) in rats. Multivariate analysis was used for metabolomic analysis. Compared with control group, NTG migraine group had 1 different metabolite up-regulated and 14 down-regulated. Compared with NTG migraine group, 13 differential metabolites in the CSD migraine model group were up-regulated and 12 were down-regulated. Both nitroglycerin-induced and mechanical stimulation-induced CSD can construct migraine rat models, and the biomarkers of the two models are different.\",\"PeriodicalId\":18318,\"journal\":{\"name\":\"Materials Express\",\"volume\":\"112 7\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Express\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1166/mex.2024.2579\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Materials Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Express","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1166/mex.2024.2579","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Materials Science","Score":null,"Total":0}
Metabonomics of brain tissue in migraine rat model induced by nitroglycerin or cortical spreading depression
This study analyzes the differences in potential biomarkers of migraine models constructed by two commonly used modeling methods through metabolomics research. Migraine models were constructed by nitroglycerin (NTG) induction or mechanical stimulus-induced cortical spreading depression (CSD) in rats. Multivariate analysis was used for metabolomic analysis. Compared with control group, NTG migraine group had 1 different metabolite up-regulated and 14 down-regulated. Compared with NTG migraine group, 13 differential metabolites in the CSD migraine model group were up-regulated and 12 were down-regulated. Both nitroglycerin-induced and mechanical stimulation-induced CSD can construct migraine rat models, and the biomarkers of the two models are different.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
