脂溢性皮炎患者血浆中的β-内啡肽水平

V. Vysochanska
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摘要

导言和目的。表皮屏障缺陷、皮脂分泌及其成分变化、马拉色菌过度生长、内分泌、免疫和神经紊乱是脂溢性皮炎(SD)的主要发病机制。"皮肤的阿片系统 "被认为是诊断和治疗脂溢性皮炎的新目标。本研究旨在确定成年脂溢性皮炎患者体内的β-内啡肽(BE)水平,并将其与症状和瘙痒的严重程度相关联。材料和方法对 26 名健康人和 62 名脂溢性皮炎患者进行了研究。采用 SEDASI 量表评估症状严重程度和瘙痒强度。β-内啡肽水平的测定采用 ELISA 法,检测系统为人 BE NBP2(78774 Novus Biologicals)。结果与对照组相比,SD 组的 BE 含量更高(35.5 pg/mL,22. pg/mL,p<0.001)。脂溢性皮炎患者的 BE 水平与年龄和性别无关,但随着症状的严重程度而上升。BE 水平与 SEDASI 之间的正相关为 0.42(p<.001),BE 水平与瘙痒之间的正相关为 0.332(p=0.009)。结论SD患者的BE水平升高与瘙痒和疾病严重程度呈正相关。
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Plasma level of beta endorphin in seborrheic dermatitis patients
Introduction and aim. Defects in the epidermal barrier, changes in sebum secretion and its composition, Malassezia spp. overgrowth, endocrine, immune, and neurological disorders are the main pathogenesis items of seborrheic dermatitis (SD). “The opioid system of the skin” was considered a new target in the diagnosis and treatment of SD. The study aimed to determine beta-endorphin (BE) levels in adult patients with seborrheic dermatitis and correlate them with the severity of symptoms and itching. Material and methods. 26 healthy and 62 SD people were examined. SEDASI scale were used to estimate the severity of symptoms and intensity of itching. The determination of the beta-endorphin level was carried out by the ELISA method with the test system Human BE NBP2 (78774 Novus Biologicals). Results. BE in the SD group was higher compared to the control group (35.5 pg/mL, 22. pg/mL, p<0.001). The level of BE in seborrheic patients did not depend on age and sex but was rising with severity of symptoms. Positive correlations were found between the level of BE and the SEDASI was 0.42 (p<.001), between the level of BE and itching was 0.332 (p=0.009). Conclusion. SD patients have an increased level of BE that positively correlates with itching and disease severity.
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