伪装成腺样体肥大的成人鼻咽伯基特淋巴瘤:诊断难题

Deepika Eswari D., Sunil Pai, Ajay Kumar, Ramnath Shenoy, David Rosario, Hanock Nischal, Herison J.
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引用次数: 0

摘要

本病例报告介绍了一名 18 岁男性在鉴别鼻咽伯基特淋巴瘤(BL)时遇到的诊断难题,该患者最初被误诊为腺样体肥大。伯基特淋巴瘤是一种罕见的侵袭性B细胞非霍奇金淋巴瘤(NHL),通常表现为颈淋巴结或面部骨骼,因此鼻咽部受累并不常见。患者的症状从鼻塞发展到口咽吞咽困难和颈部肿胀,这促使他接受进一步检查。包括CT扫描在内的放射学评估均未得出结论,最终通过切除活检和免疫组化确诊为BL,CD20、CD10和Bcl-6均有表达。经过六个周期的化疗,患者的病情得到了完全缓解。该病例强调了考虑非典型表现的罕见恶性肿瘤的重要性,并突出了综合诊断方法在实现准确及时治疗中的作用。
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Nasopharyngeal Burkitt lymphoma masquerading as adenoid hypertrophy in an adult: a diagnostic challenge
This case report presents the diagnostic challenges encountered in identifying nasopharyngeal Burkitt lymphoma (BL) in an 18- year-old male initially misdiagnosed with adenoid hypertrophy. BL, a rare and aggressive B-cell non-Hodgkin’s lymphoma (NHL), typically manifests in cervical lymphnodes or facial bones, making nasopharyngeal involvement unusual. The patient's symptoms progressed from nasal blockage to oropharyngeal dysphagia and neck swelling, prompting further investigation. Radiological assessments, including a CT scan, were inconclusive, leading to a diagnosis through excisional biopsy and immunohistochemistry, confirming BL with CD20, CD10, and Bcl-6 expression. Successful treatment involved six cycles of chemotherapy, resulting in complete remission. This case underscores the importance of considering rare malignancies in atypical presentations and highlights the role of comprehensive diagnostic approaches in achieving accurate and timely management.
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