评估旋转磁场对不同药物制剂中布洛芬渗透性的影响

IF 2.3 Q3 PHARMACOLOGY & PHARMACY Scientia Pharmaceutica Pub Date : 2023-12-29 DOI:10.3390/scipharm92010004
Anna Nowak, Paula Ossowicz-Rupniewska, M. Konopacki, Anna Muzykiewicz-Szymańska, Łukasz Kucharski, R. Rakoczy
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引用次数: 0

摘要

本研究介绍了一种利用旋转磁场(RMF)提高布洛芬透皮渗透性的新方法。其核心目标是系统地评估 50 赫兹 RMF 对布洛芬在各种制剂类型中的皮肤渗透性的影响,每种制剂都采用了不同的物理形式和辅料。实验装置包括以皮肤为膜的弗兰茨细胞,暴露在 50 赫兹 RMF 和特定配方中。随后的综合分析表明,无论采用哪种制剂,布洛芬的透皮转运能力都有显著提高。值得注意的是,最初 30 分钟的渗透差异尤为明显。最重要的是,这项研究证实,与未接触 50 赫兹 RMF 的对照组相比,使用 50 赫兹 RMF 后布洛芬的渗透性显著增加了七倍多。值得注意的是,在所有测试的半固体药物制剂中,RMF 都能有效地将延迟时间缩短为零,这表明 RMF 能有效克服透皮给药的障碍。这项研究将 RMF 的应用定位为一项极具前景的创新技术,它能显著增强消炎药和镇痛药在皮肤中的透皮渗透。RMF在不同配方中的有效性表明了它在透皮给药方面的潜力,为改善布洛芬和其他潜在药物的治疗效果提供了一种新颖而有效的策略。
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Assessing the Influence of a Rotating Magnetic Field on Ibuprofen Permeability from Diverse Pharmaceutical Formulations
This study introduces a novel approach for enhancing the transdermal permeability of ibuprofen through the skin by utilising a rotating magnetic field (RMF). The core objective is to systematically evaluate the influence of a 50 Hz RMF on ibuprofen’s skin permeability across various formulation types, each employing distinct physical forms and excipients. The experimental setup involved Franz cells with skin as the membrane, exposed to a 50 Hz RMF in conjunction with specific formulations. Subsequent comprehensive analysis revealed a notable increase in the transdermal transport of ibuprofen, irrespective of the formulation employed. Notably, the differences in the initial 30 min of permeation were particularly pronounced. Crucially, this investigation establishes that the application of a 50 Hz RMF resulted in a remarkable over-sevenfold increase in ibuprofen permeability compared to the control group without RMF exposure. It is noteworthy that in all semi-solid pharmaceutical formulations tested, RMF effectively reduced the delay time to zero, underscoring the efficiency of RMF in overcoming barriers to transdermal drug delivery. This research positions the application of RMF as a highly promising and innovative technology, significantly enhancing the transdermal penetration of anti-inflammatory and analgesic drugs through the skin. The demonstrated effectiveness of RMF across diverse formulations suggests its potential in transdermal drug delivery, offering a novel and efficient strategy for improving therapeutic outcomes in the administration of ibuprofen and potentially other pharmaceutical agents.
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来源期刊
Scientia Pharmaceutica
Scientia Pharmaceutica Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.60
自引率
4.00%
发文量
67
审稿时长
10 weeks
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