基于蓝藻和微藻的新型抗癌纳米制剂及其在医学、牙科和药学中的应用综述

Bahareh Nowruzi, Nazaninsadat Hashemizaveh
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摘要

导言:纳米粒子具有表面积比大、粒度分布均匀、稳定性高和易于生产等特点,因此被广泛应用于制药、牙科、医学、生物学和材料工程等各个领域。大量致病细菌的存在会引起各种感染,削弱人体免疫系统,并在食品包装、合成纺织品、医疗和牙科设备等领域构成重大风险,同时也是与饮用水和污水处理有关的公共卫生问题,这些都推动了涂层的形成。许多致病细菌会引起各种感染,削弱人体免疫系统,并在食品包装、合成纺织品、医疗和牙科设备等领域构成重大风险,同时也是与饮用水和污水处理有关的公共卫生问题的主要来源。50%以上的海洋蓝藻可被用于提取生物活性物质,并可通过诱导细胞凋亡有效地杀死癌症。在这篇综述文章中,重点介绍了基于微藻的药物或化合物领域的最新研究及其生物医学应用。同样,文章还强调了在发现抗癌化合物、微藻抗癌药物的商业化、基于微藻的纳米配方药物的生产、高载药量给药配方的生产及其在医学、药学和牙科领域的应用等方面的最新进展。 结论利用蓝藻开发和改进纳米粒子生物合成工艺,可能会发现具有独特性能的新型生物纳米粒子,从而显著提高医疗效果并减少副作用。
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A Review of New Anticancer Nanoformulations based on Cyanobacteria and Microalgae and its Application in Medical Sciences, Dentistry and Pharmacy
Introduction: Nanoparticles are widely used in various fields of pharmaceuticals, dentistry, medicine, biology and materials engineering due to their special features, including high surface-to-volume ratio, homogeneous particle size distribution, high stability, and ease of production. The formation of coatings is driven by the existence of numerous pathogenic bacteria that give rise to diverse infections, weaken the immune system in humans, and pose significant risks in areas such as food packaging, synthetic textiles, medical and dental equipment, as well as public health concerns related to drinking water and sewage treatment. The formation of coatings is driven by the existence of numerous pathogenic bacteria that give rise to diverse infections, weaken the immune system in humans, and pose significant risks in areas such as food packaging, synthetic textiles, medical and dental equipment, as well as public health concerns related to drinking water and sewage treatment. More than 50% of marine cyanobacteria can potentially be used to extract bioactive substances and are known to be very effective in killing cancer by inducing apoptotic death. In this review article, recent researches in the field of drugs or compounds based on microalgae and also their biomedical applications are emphasized. Likewise, recent advances in the field of discovering anticancer compounds, commercialization of microalgae anticancer drugs, production of nanoformulated drugs based on microalgae, and production of formulations for high loading drug delivery and its application in medical sciences, pharmacy and dentistry are emphasized. Conclusion: The development and improvement of nanoparticle biosynthesis processes using cyanobacteria may leads to the discovery of new biogenic nanoparticles with unique properties that can significantly increase the effectiveness of medical treatments and reduce side effects.
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