使用皮下植入物治疗勃起功能障碍的长期效果

Mykola Boiko, Anton S. Glebov, Sergii P. Pasiechnikov, Oleksandr Boiko
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摘要

导言。文章介绍了一种通过皮下植入长效磷酸二酯酶 5 (PDE 5) 抑制剂来改善勃起功能的新方法。 研究目的评估他达拉非使用生物同源颗粒治疗勃起功能障碍的效果。 材料和方法:研究对象包括 10 名 65 岁以下、患有勃起功能障碍 1 年以上的男性。 在干预前和干预后 4 个月进行了以下检查:填写 MIEF-5 问卷、phical 检查、阴茎血管多普勒检查、"勃起硬度量表"、实验室检查(一般和生化血液检查、一般尿液分析和激素检测,包括测定总睾酮、游离睾酮、催乳素、雌二醇和硫酸脱氢表雄酮的水平。 所有患者都接受了生物同源他达拉非 75 毫克的植入。在无菌手术室中,通过臀部外象限 3 毫米的皮肤切口,将颗粒植入皮下脂肪中。 结果所有患者的 MIEF-5 均有所改善,从 14.7 ± 2.75 提高到 20.7 ± 1.49,多普勒血管检查显示,注射前列腺素 E1 后第 10 分钟,收缩期血流速度和阴茎硬度均有所提高。 结论本研究证明了他达拉非颗粒剂治疗 65 岁以下男性勃起功能障碍的疗效。
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ERECTILE DYSFUNCTION TREATMENT USING SUBCUTANEOUS IMPLANTS WITH A LONG-TERM EFFECT
Introduction. The article describes a new method of improving erectile function by incerting long-acting subcutaneous implants with the phosphodiesterase 5 (PDE 5) inhibitor. The aim of the study: To evaluate the effectiveness of tadalafil in the treatment of erectile dysfunction using bioidentical pellets. Materials and methods: The study included 10 men under 65 years of age who had suffered from erectile dysfunction for more than 1 year. For the examination before and 4 months after the intervention, the following were performed: filling out the MIEF-5 questionnaire, phical examination, Doppler of penile vessels, «Erection Hardness Scale», laboratory examination (general and biochemical blood tests, general urine analysis and hormonal testing, including determination of the levels of total testosterone, free testosterone, prolactin, estradiol and dehydroepiandrosterone sulfate. All patients received implants with bioidentical tadalafil 75 mg. The pellet was inserted in a sterile operating room through a 3 mm skin incision in the outer quadrant of the gluteal region and inserting the substance into the subcutaneous fat. Results: All patients showed an improvement in MIEF-5 from 14.7 ± 2.75 to 20.7 ± 1.49, an increase in systolic blood flow velocity and penile rigidity at the tenth minute after prostaglandin E1 injection on Doppler vascular examination. Conclusion: This study demonstrated the efficacy of tadalafil by pellet administration in the treatment of erectile dysfunction in men younger than 65 years.
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