Clear cell carcinoma of Müllerian origin

Clear cell carcinoma is structures of Mullerian origin, they are associated with mutations in TP53 as they are a high-grade neoplasm, however there is no immunophenotypic pattern that guides us if the origin is from the ovary, uterus, endocervix or endometrium. A 71-year-old female patient who underwent surgery for a right parauterine tumor with a pathological report that corresponded to a clear cell tumor. Subsequently, a staging and cytoreductive laparotomy was performed, performing abdominal cavity lavage, salpingo-oophorectomy of the remaining ovary (left), and pelvic and paraortic lymphadenectomy. , omentectomy and biopsies of the parietal peritoneum, all the material was negative for metastatic disease, 18 months later there was a relapse in the vaginal vault, with the presence of an ovoid tumor measuring 10 cm in diameter, treated with colpectomy, with a report of clear cell carcinoma with CK7+ / Napsin A+ / p53+ protein immunophenotype, with a satisfactory disease-free postoperative period.