{"title":"鼻炎患者全身炎症指标评估","authors":"Sümeyra Alan Yalim, Ayse Füsun Kalpaklıoglu, Ayşe Baccıoglu, Merve Poyraz, Gulistan Alpagat, Betul Dumanoglu","doi":"10.1007/s40629-023-00277-2","DOIUrl":null,"url":null,"abstract":"<p>Rhinitis affects the majority of the population. It may generate localized nasal mucosal inflammation via allergic (AR) or nonallergic (NAR) processes, but it is unknown if this might also result in systemic inflammation, which can raise morbidity and death. Using current serum inflammatory markers, we sought to investigate systemic inflammation in patients with chronic rhinitis.</p><p>In this retrospective case–control study, we included 439 patients with newly diagnosed AR (<i>n</i> = 179), NAR (<i>n</i> = 157), and 103 healthy individuals. Inflammation-related blood parameters were collected as lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), eosinophil/neutrophil ratio (ELR), and systemic immune inflammation index (SII).</p><p>All groups were similar in terms of age, gender, and body mass index. Neutrophil counts were significantly higher both in AR and NAR groups compared to controls (4.51 ± 0.09, 4.54 ± 0.1 vs. 3.73 ± 0.1, <i>p</i> < 0.001). NLR (1.91 ± 0.56, 1.89 ± 0.61, 1.61 ± 0.59, <i>p</i> < 0.001), LMR (5.76 ± 0.17, 5.93 ± 0.17, 5.1 ± 0.15, <i>p</i> = 0.005), ELR (0.1335 ± 0.007, 0.0999 ± 0.006, 0.12 ± 0.009, <i>p</i> = 0.003), SII (533.3 ± 16.6, 558.1 ± 20.9, 479.9 ± 22.2, <i>p</i> = 0.035), and CRP (1.44 ± 0.09, 1.67 ± 0.09, 0.87 ± 0.04, <i>p</i> < 0.001) were significantly higher in AR and NAR groups than the controls, respectively. SII (r = 0.146, <i>p</i> = 0.007) and ELR (r = 0.254, <i>p</i> < 0.001) were correlated with the presence of asthma.</p><p>We found that systemic circulation of inflammatory cells was significantly increased in rhinitis with/without allergy compared to the control group. This study showed that not only AR, but also NAR triggers a systemic increase of inflammation which supports the link between rhinitis and comorbid conditions such as asthma. Therefore, effective treatment may be suggested for local inflammation and its systemic manifestations.</p>","PeriodicalId":37457,"journal":{"name":"Allergo Journal International","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of systemic inflammation markers in patients with rhinitis\",\"authors\":\"Sümeyra Alan Yalim, Ayse Füsun Kalpaklıoglu, Ayşe Baccıoglu, Merve Poyraz, Gulistan Alpagat, Betul Dumanoglu\",\"doi\":\"10.1007/s40629-023-00277-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Rhinitis affects the majority of the population. It may generate localized nasal mucosal inflammation via allergic (AR) or nonallergic (NAR) processes, but it is unknown if this might also result in systemic inflammation, which can raise morbidity and death. Using current serum inflammatory markers, we sought to investigate systemic inflammation in patients with chronic rhinitis.</p><p>In this retrospective case–control study, we included 439 patients with newly diagnosed AR (<i>n</i> = 179), NAR (<i>n</i> = 157), and 103 healthy individuals. Inflammation-related blood parameters were collected as lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), eosinophil/neutrophil ratio (ELR), and systemic immune inflammation index (SII).</p><p>All groups were similar in terms of age, gender, and body mass index. Neutrophil counts were significantly higher both in AR and NAR groups compared to controls (4.51 ± 0.09, 4.54 ± 0.1 vs. 3.73 ± 0.1, <i>p</i> < 0.001). NLR (1.91 ± 0.56, 1.89 ± 0.61, 1.61 ± 0.59, <i>p</i> < 0.001), LMR (5.76 ± 0.17, 5.93 ± 0.17, 5.1 ± 0.15, <i>p</i> = 0.005), ELR (0.1335 ± 0.007, 0.0999 ± 0.006, 0.12 ± 0.009, <i>p</i> = 0.003), SII (533.3 ± 16.6, 558.1 ± 20.9, 479.9 ± 22.2, <i>p</i> = 0.035), and CRP (1.44 ± 0.09, 1.67 ± 0.09, 0.87 ± 0.04, <i>p</i> < 0.001) were significantly higher in AR and NAR groups than the controls, respectively. SII (r = 0.146, <i>p</i> = 0.007) and ELR (r = 0.254, <i>p</i> < 0.001) were correlated with the presence of asthma.</p><p>We found that systemic circulation of inflammatory cells was significantly increased in rhinitis with/without allergy compared to the control group. This study showed that not only AR, but also NAR triggers a systemic increase of inflammation which supports the link between rhinitis and comorbid conditions such as asthma. Therefore, effective treatment may be suggested for local inflammation and its systemic manifestations.</p>\",\"PeriodicalId\":37457,\"journal\":{\"name\":\"Allergo Journal International\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Allergo Journal International\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40629-023-00277-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergo Journal International","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s40629-023-00277-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Evaluation of systemic inflammation markers in patients with rhinitis
Rhinitis affects the majority of the population. It may generate localized nasal mucosal inflammation via allergic (AR) or nonallergic (NAR) processes, but it is unknown if this might also result in systemic inflammation, which can raise morbidity and death. Using current serum inflammatory markers, we sought to investigate systemic inflammation in patients with chronic rhinitis.
In this retrospective case–control study, we included 439 patients with newly diagnosed AR (n = 179), NAR (n = 157), and 103 healthy individuals. Inflammation-related blood parameters were collected as lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), eosinophil/neutrophil ratio (ELR), and systemic immune inflammation index (SII).
All groups were similar in terms of age, gender, and body mass index. Neutrophil counts were significantly higher both in AR and NAR groups compared to controls (4.51 ± 0.09, 4.54 ± 0.1 vs. 3.73 ± 0.1, p < 0.001). NLR (1.91 ± 0.56, 1.89 ± 0.61, 1.61 ± 0.59, p < 0.001), LMR (5.76 ± 0.17, 5.93 ± 0.17, 5.1 ± 0.15, p = 0.005), ELR (0.1335 ± 0.007, 0.0999 ± 0.006, 0.12 ± 0.009, p = 0.003), SII (533.3 ± 16.6, 558.1 ± 20.9, 479.9 ± 22.2, p = 0.035), and CRP (1.44 ± 0.09, 1.67 ± 0.09, 0.87 ± 0.04, p < 0.001) were significantly higher in AR and NAR groups than the controls, respectively. SII (r = 0.146, p = 0.007) and ELR (r = 0.254, p < 0.001) were correlated with the presence of asthma.
We found that systemic circulation of inflammatory cells was significantly increased in rhinitis with/without allergy compared to the control group. This study showed that not only AR, but also NAR triggers a systemic increase of inflammation which supports the link between rhinitis and comorbid conditions such as asthma. Therefore, effective treatment may be suggested for local inflammation and its systemic manifestations.
期刊介绍:
Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies.
All submissions are reviewed in single-blind fashion by at least two reviewers.
Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.