{"title":"大量饮用咖啡与非酒精性脂肪性肝炎患者肝纤维化程度降低无关：COCANASH 研究结果","authors":"Hugues Blondon , Marc Delord , Simona Cosconea , Simona Tirziu , Marie-Pierre Ripault , Florent Ehrhard , Matthieu Schnee , Khaldoun Elriz , Mathilde Fron , Kamel Benghalia , Margot Laly , Sylvie Roussin-Bretagne , Carelle Koudougou , Gwenaelle Petit-Aubert , Vincent Mace , Michel Chochon , Cécile Garceau , Philippe Colardelle , Ludovic Lagin , Mélody Fort , Cédric Villain","doi":"10.1016/j.nupar.2023.10.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The beneficial effect of coffee consumption on the progression of liver fibrosis in NASH is controversial.</p></div><div><h3>Aims</h3><p>To compare coffee consumption in NASH patients with and without advanced fibrosis.</p></div><div><h3>Methods</h3><p>Cross-sectional observational study on 97 patients with NASH diagnosed by histology or the association of steatosis, metabolic syndrome, elastometry<!--> <!-->><!--> <!-->6<!--> <!-->kPa, and exclusion of other liver diseases. Usual coffee and caffeine intake were assessed using a standardized questionnaire. Liver fibrosis was evaluated by elastometry (advanced fibrosis if ≥<!--> <!-->10<!--> <!-->kPa).</p></div><div><h3>Results</h3><p>Among the 97 patients, 49 patients (51%) had non-advanced fibrosis (group 1) and 48 (49%) advanced fibrosis (group 2). The mean consumption of caffeine from coffee was 251<!--> <!-->mg<!--> <!-->±<!--> <!-->293 per day in group 1 and 257<!--> <!-->mg<!--> <!-->±<!--> <!-->286 per day in group 2 (<em>P</em> <!-->=<!--> <!-->0.92). In multivariable analysis, the odds ratio for the mean consumption of caffeine from coffee (100<!--> <!-->mg/d) between groups was 1.00 (1.00–1.00, <em>P</em> <!-->=<!--> <!-->0.92). There was no correlation between elastometry and the consumption of caffeine from coffee.</p></div><div><h3>Conclusion</h3><p>We found no relationship between caffeine or coffee consumption and the degree of liver fibrosis in NASH. Our result does not support a beneficial effect of coffee consumption on the progression of fibrosis in NASH.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 1","pages":"Pages 22-26"},"PeriodicalIF":0.5000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High coffee consumption is not associated with less liver fibrosis in non-alcoholic steato-hepatitis: Results of the COCANASH study\",\"authors\":\"Hugues Blondon , Marc Delord , Simona Cosconea , Simona Tirziu , Marie-Pierre Ripault , Florent Ehrhard , Matthieu Schnee , Khaldoun Elriz , Mathilde Fron , Kamel Benghalia , Margot Laly , Sylvie Roussin-Bretagne , Carelle Koudougou , Gwenaelle Petit-Aubert , Vincent Mace , Michel Chochon , Cécile Garceau , Philippe Colardelle , Ludovic Lagin , Mélody Fort , Cédric Villain\",\"doi\":\"10.1016/j.nupar.2023.10.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The beneficial effect of coffee consumption on the progression of liver fibrosis in NASH is controversial.</p></div><div><h3>Aims</h3><p>To compare coffee consumption in NASH patients with and without advanced fibrosis.</p></div><div><h3>Methods</h3><p>Cross-sectional observational study on 97 patients with NASH diagnosed by histology or the association of steatosis, metabolic syndrome, elastometry<!--> <!-->><!--> <!-->6<!--> <!-->kPa, and exclusion of other liver diseases. Usual coffee and caffeine intake were assessed using a standardized questionnaire. Liver fibrosis was evaluated by elastometry (advanced fibrosis if ≥<!--> <!-->10<!--> <!-->kPa).</p></div><div><h3>Results</h3><p>Among the 97 patients, 49 patients (51%) had non-advanced fibrosis (group 1) and 48 (49%) advanced fibrosis (group 2). The mean consumption of caffeine from coffee was 251<!--> <!-->mg<!--> <!-->±<!--> <!-->293 per day in group 1 and 257<!--> <!-->mg<!--> <!-->±<!--> <!-->286 per day in group 2 (<em>P</em> <!-->=<!--> <!-->0.92). In multivariable analysis, the odds ratio for the mean consumption of caffeine from coffee (100<!--> <!-->mg/d) between groups was 1.00 (1.00–1.00, <em>P</em> <!-->=<!--> <!-->0.92). There was no correlation between elastometry and the consumption of caffeine from coffee.</p></div><div><h3>Conclusion</h3><p>We found no relationship between caffeine or coffee consumption and the degree of liver fibrosis in NASH. Our result does not support a beneficial effect of coffee consumption on the progression of fibrosis in NASH.</p></div>\",\"PeriodicalId\":54702,\"journal\":{\"name\":\"Nutrition Clinique et Metabolisme\",\"volume\":\"38 1\",\"pages\":\"Pages 22-26\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Clinique et Metabolisme\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0985056223002819\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Clinique et Metabolisme","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0985056223002819","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
High coffee consumption is not associated with less liver fibrosis in non-alcoholic steato-hepatitis: Results of the COCANASH study
Background
The beneficial effect of coffee consumption on the progression of liver fibrosis in NASH is controversial.
Aims
To compare coffee consumption in NASH patients with and without advanced fibrosis.
Methods
Cross-sectional observational study on 97 patients with NASH diagnosed by histology or the association of steatosis, metabolic syndrome, elastometry > 6 kPa, and exclusion of other liver diseases. Usual coffee and caffeine intake were assessed using a standardized questionnaire. Liver fibrosis was evaluated by elastometry (advanced fibrosis if ≥ 10 kPa).
Results
Among the 97 patients, 49 patients (51%) had non-advanced fibrosis (group 1) and 48 (49%) advanced fibrosis (group 2). The mean consumption of caffeine from coffee was 251 mg ± 293 per day in group 1 and 257 mg ± 286 per day in group 2 (P = 0.92). In multivariable analysis, the odds ratio for the mean consumption of caffeine from coffee (100 mg/d) between groups was 1.00 (1.00–1.00, P = 0.92). There was no correlation between elastometry and the consumption of caffeine from coffee.
Conclusion
We found no relationship between caffeine or coffee consumption and the degree of liver fibrosis in NASH. Our result does not support a beneficial effect of coffee consumption on the progression of fibrosis in NASH.
期刊介绍：
Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.
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