CTRP13 通过 AMPK/KLF4 通路减轻内皮细胞铁素沉着：对动脉粥样硬化保护的意义

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Medical Science Monitor Pub Date : 2023-11-29 DOI:10.12659/msm.942733

Jie Du, Jianjun Wu, Youqi Zhang, Qi Liu, Xing Luo, Xingtao Huang, Xuedong Wang, Fan Yang, JingBo Hou

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引用次数: 0

摘要

C1q/肿瘤坏死因子相关蛋白 13（CTRP13）可保护内皮功能并具有抗氧化活性。然而，它对人脐静脉内皮细胞（HUVECs）铁沉着的影响仍不清楚。我们研究了 CTRP13 对氧化低密度脂蛋白（ox-LDL）诱导的 HUVEC 铁沉降的影响，并探讨了 CTRP13 通过 AMPK/KLF4 通路抗铁沉降的内在机制。

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CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis Protection

C1q/tumor necrosis factor-related protein 13 (CTRP13) preserves endothelial function and possesses anti-oxidation activity. However, its effects on ferroptosis of human umbilical vein endothelial cells (HUVECs) remain unclear. We investigated the effects of CTRP13 on HUVEC ferroptosis induced by oxidized low-density lipoprotein (ox-LDL) and explored the underlying mechanisms of CTRP13 against ferroptosis via the AMPK/KLF4 pathway.

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来源期刊

Medical Science Monitor 医学-医学：研究与实验

自引率

3.20%

发文量

514

审稿时长

3 months

期刊介绍： Medical Science Monitor (MSM) established in 1995 is an international, peer-reviewed scientific journal which publishes original articles in Clinical Medicine and related disciplines such as Epidemiology and Population Studies, Product Investigations, Development of Laboratory Techniques :: Diagnostics and Medical Technology which enable presentation of research or review works in overlapping areas of medicine and technology such us (but not limited to): medical diagnostics, medical imaging systems, computer simulation of health and disease processes, new medical devices, etc. Reviews and Special Reports - papers may be accepted on the basis that they provide a systematic, critical and up-to-date overview of literature pertaining to research or clinical topics. Meta-analyses are considered as reviews. A special attention will be paid to a teaching value of a review paper. Medical Science Monitor is internationally indexed in Thomson-Reuters Web of Science, Journals Citation Report (JCR), Science Citation Index Expanded (SCI), Index Medicus MEDLINE, PubMed, PMC, EMBASE/Excerpta Medica, Chemical Abstracts CAS and Index Copernicus.