{"title":"Curcumin as a Potential Therapeutic Agent for Mitigating Carbon Monoxide Poisoning: Evidence from an Experimental Rat Study","authors":"G. Doğan, Selçuk Kayır, Ercan Ayaz, Oğuzhan Özcan, Arzu Akdağlı Ekici","doi":"10.12659/msm.943739","DOIUrl":"https://doi.org/10.12659/msm.943739","url":null,"abstract":"","PeriodicalId":49834,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140984279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving Function and Quality of Life in Patients with Chronic Neck Pain, Tension-Type Headache, and Forward Head Posture: The Role of Eyeball Exercise and Cervical Stabilization Programs","authors":"Sam-Ho Park, Youn-Joong Oh, Myungmo Lee","doi":"10.12659/msm.944315","DOIUrl":"https://doi.org/10.12659/msm.944315","url":null,"abstract":"","PeriodicalId":49834,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanqing Gu, Wengbo Yang, Yan Ren, Chenyang Xu, Lei Zhao, Chunzhi Jiang
{"title":"Outcomes of Anterior Lateral Approach and Gerdy's Tubercle Osteotomy for Tibial Plateau Fractures Involving the Posterior Lateral Condyle: A Retrospective Study of 20 Patients","authors":"Yanqing Gu, Wengbo Yang, Yan Ren, Chenyang Xu, Lei Zhao, Chunzhi Jiang","doi":"10.12659/msm.943946","DOIUrl":"https://doi.org/10.12659/msm.943946","url":null,"abstract":"","PeriodicalId":49834,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Scaphoid nonunion (SN) is a challenging condition in wrist pathology, often resulting in severe consequences if left untreated. Surgical intervention, particularly using vascularized bone grafts (VBGs), is a promising but uncertain approach. The 4+5 extensor compartment artery (ECA) pedicled graft, less commonly used for SN, has potential benefits due to its vascular supply and accessibility to the scaphoid. This study aimed to evaluate the effectiveness of the 4+5 ECA pedicled graft combined with headless compression screw fixation in treating avascular necrosis (AVN)-induced proximal pole SN. Radiological results, functional outcomes, and complications related to this method were assessed. Material/Methods: This was a retrospective analysis of 19 proximal pole SN cases with AVN treated using the 4+5 ECA-VBG technique from 2016 to 2022. Patients underwent preoperative evaluation and postoperative follow-up for at least 1 year. Data on surgery, demographics, radiological assessments, and functional outcomes were recorded and analyzed statistically. Results: All patients achieved radiographic union within 8.5 weeks postoperatively, with revascularization of proximal pole necrosis. Significant improvements in functional outcomes were observed, including pain reduction, increased wrist range of motion, improved grip and pinch strength, and enhanced wrist scores. No major complications were reported. Conclusions: The 4+5 ECA-VBG technique, with headless compression screw fixation, showed high success rates in treating AVN-induced proximal pole SN. This method offers comprehensive restoration of wrist function and minimal complications, making it a viable option for SN management, especially in AVN cases. Further research is needed to confirm these results and establish standardized protocols for SN treatment
背景：肩胛骨骨不连（SN）是腕关节病理学中的一个难题，如果不及时治疗，往往会导致严重后果。手术干预，尤其是使用血管化骨移植（VBGs），是一种前景广阔但不确定的方法。4+5伸肌室动脉（ECA）带蒂移植物较少用于SN，但因其血管供应和可接近肩胛骨而具有潜在优势。本研究旨在评估 4+5 ECA 有蒂移植物结合无头加压螺钉固定治疗由血管坏死（AVN）引起的近极 SN 的有效性。对该方法的放射学结果、功能结果和并发症进行了评估。材料/方法：这是对2016年至2022年使用4+5 ECA-VBG技术治疗的19例AVN近极SN病例的回顾性分析。患者接受了术前评估和至少 1 年的术后随访。记录并统计分析了手术、人口统计学、放射学评估和功能结果等数据。结果所有患者均在术后 8.5 周内达到放射学结合，近端坏死血管再通。术后患者的功能明显改善，包括疼痛减轻、腕关节活动范围增大、握力和捏力增强以及腕关节评分提高。无重大并发症报告。结论采用无头加压螺钉固定的 4+5 ECA-VBG 技术治疗 AVN 引起的近端 SN 成功率很高。该方法可全面恢复腕关节功能，并发症极少，是治疗SN的可行方法，尤其适用于AVN病例。还需要进一步的研究来证实这些结果，并为 SN 治疗制定标准化方案。
{"title":"Treatment of AVN-Induced Proximal Pole Scaphoid Nonunion Using a Fifth and Fourth Extensor Compartmental Artery as a Vascularized Pedicle Bone Graft: A Retrospective Case Series","authors":"M. Adaş","doi":"10.12659/msm.944553","DOIUrl":"https://doi.org/10.12659/msm.944553","url":null,"abstract":"Background: Scaphoid nonunion (SN) is a challenging condition in wrist pathology, often resulting in severe consequences if left untreated. Surgical intervention, particularly using vascularized bone grafts (VBGs), is a promising but uncertain approach. The 4+5 extensor compartment artery (ECA) pedicled graft, less commonly used for SN, has potential benefits due to its vascular supply and accessibility to the scaphoid. This study aimed to evaluate the effectiveness of the 4+5 ECA pedicled graft combined with headless compression screw fixation in treating avascular necrosis (AVN)-induced proximal pole SN. Radiological results, functional outcomes, and complications related to this method were assessed. Material/Methods: This was a retrospective analysis of 19 proximal pole SN cases with AVN treated using the 4+5 ECA-VBG technique from 2016 to 2022. Patients underwent preoperative evaluation and postoperative follow-up for at least 1 year. Data on surgery, demographics, radiological assessments, and functional outcomes were recorded and analyzed statistically. Results: All patients achieved radiographic union within 8.5 weeks postoperatively, with revascularization of proximal pole necrosis. Significant improvements in functional outcomes were observed, including pain reduction, increased wrist range of motion, improved grip and pinch strength, and enhanced wrist scores. No major complications were reported. Conclusions: The 4+5 ECA-VBG technique, with headless compression screw fixation, showed high success rates in treating AVN-induced proximal pole SN. This method offers comprehensive restoration of wrist function and minimal complications, making it a viable option for SN management, especially in AVN cases. Further research is needed to confirm these results and establish standardized protocols for SN treatment","PeriodicalId":49834,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Ege, Memet Aslanyavrusu, B. Uzunok, Oğuzhan Özdemir
{"title":"Effects of the Cold Pressor Test on Popliteal Vein Diameter, Flow Velocity, and Blood Flow in the Lower Limb in 60 Healthy Individuals","authors":"F. Ege, Memet Aslanyavrusu, B. Uzunok, Oğuzhan Özdemir","doi":"10.12659/msm.944560","DOIUrl":"https://doi.org/10.12659/msm.944560","url":null,"abstract":"","PeriodicalId":49834,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Sun, Jichao Liu, Weibo Jiang, Chao Gao, Yichun Qiao, Yanguo Qin, Jincheng Wang
{"title":"Epidemiology and Risk Factors for Revision Total Knee Arthroplasty in Chinese Patients: A Retrospective Study in Changchun, Jilin Province, China","authors":"Yang Sun, Jichao Liu, Weibo Jiang, Chao Gao, Yichun Qiao, Yanguo Qin, Jincheng Wang","doi":"10.12659/msm.943681","DOIUrl":"https://doi.org/10.12659/msm.943681","url":null,"abstract":"","PeriodicalId":49834,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zheng Zhu, Bizhi Tu, Run Fang, Jun Tong, Yulong Liu, Rende Ning
genes showed associations with immune-related cell infiltration and levels of inflammatory cytokines. Furthermore, we observed heterogeneity in the expression patterns of hub genes across different clusters of OA. Notably, older patients displayed increased susceptibility to elevated levels of pain-related inflammatory cytokines and infiltration of immune cells. Conclusions: The SMP-related hub genes have the potential to serve as diagnostic markers for OA patients. Moreover, the 4 hub genes of SMP demonstrate wide participation in immune dysregulation in OA synovium. The activation of different pathways is observed among different populations of patients with OA.
这些基因与免疫相关细胞浸润和炎症细胞因子水平有关。此外，我们还观察到 OA 不同群组中枢基因表达模式的异质性。值得注意的是，老年患者更容易出现疼痛相关炎性细胞因子水平升高和免疫细胞浸润。结论与 SMP 相关的枢纽基因有可能成为 OA 患者的诊断标志物。此外，SMP 的 4 个枢纽基因广泛参与了 OA 滑膜的免疫失调。在不同的 OA 患者人群中观察到了不同途径的激活。
{"title":"Comprehensive Analysis of Sphingolipid Metabolism-Related Genes in Osteoarthritic Diagnosis and Synovial Immune Dysregulation","authors":"Zheng Zhu, Bizhi Tu, Run Fang, Jun Tong, Yulong Liu, Rende Ning","doi":"10.12659/msm.943369","DOIUrl":"https://doi.org/10.12659/msm.943369","url":null,"abstract":"genes showed associations with immune-related cell infiltration and levels of inflammatory cytokines. Furthermore, we observed heterogeneity in the expression patterns of hub genes across different clusters of OA. Notably, older patients displayed increased susceptibility to elevated levels of pain-related inflammatory cytokines and infiltration of immune cells. Conclusions: The SMP-related hub genes have the potential to serve as diagnostic markers for OA patients. Moreover, the 4 hub genes of SMP demonstrate wide participation in immune dysregulation in OA synovium. The activation of different pathways is observed among different populations of patients with OA.","PeriodicalId":49834,"journal":{"name":"Medical Science Monitor","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141009081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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