质子泵抑制剂疗法对喉咽反流的经验作用研究

N. Chhabra, Ankita Aggarwal, Sanjeev Bhagat, Khushboo Goel
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摘要

背景:喉咽反流(LPR)是一种高发疾病,在耳鼻喉科医生的诊室中经常会遇到。本研究旨在评估 LPR 不同体征和症状的表现,并通过观察经验性 PPI(质子泵抑制剂)对 RFS 和 RSI 的影响,评估其在 LPR 治疗中的作用。研究方法对 100 例具有不同症状的 LPR 病例进行了前瞻性观察研究。反流症状指数(RSI)和反流发现评分(RFS)用于诊断 LPR。患者服用 PPI(泮托拉唑 40 毫克,口服,12 周),并在 4、8 和 12 周时进行随访,评估连续的 RSI 和 RFS 评分。对结果进行汇总和统计分析。结果在所有症状中,LPR 最常见的症状是咽喉异物感(80%)。使用 PPIs(泮托拉唑)进行药物治疗后,在 PPI 治疗 12 周时,RSI 平均得分从 22.94±5.83 降至 11.19±2.97。PPI 治疗 12 周后,平均 RFS 评分从(12.93±3.55)分变为(6.86±2.86)分。RFS和RSI评分的变化非常显著(P=0.001)。结论LPR 是耳鼻喉科常见疾病,其症状和体征可能很复杂。RFS 和 RSI 评分是诊断 LPR 的重要工具。事实证明,PPIs 是治疗 LPR 的有效药物,我们鼓励开展更多研究,以确认 PPIs 相对于其他治疗方案的疗效。
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Study of the empirical role of proton pump inhibitor therapy on laryngopharyngeal reflux
Background: Laryngopharyngeal reflux (LPR) is a highly prevalent disease and commonly encountered in the otolaryngologist’s office. Study to evaluate the presentation of different signs and symptoms of LPR along with evaluating the role of empiric PPI (proton pump inhibitor) in the management of LPR by observing its effect on RFS and RSI. Methods: A prospective observational study was conducted on 100 cases having different symptoms of LPR. Reflux symptom index (RSI) and Reflux finding score (RFS) were used to diagnose LPR. Patients were put on PPI (Pantoprazole 40 mg OD for 12 weeks) and followed up at 4,8 and 12 weeks and successive RSI and RFS scores were evaluated. The results were compiled and analyzed statistically. Results: Among all symptoms, most common presenting symptom of LPR was foreign body/sensation of something sticking in throat (80%). Upon pharmacological therapy with PPIs (Pantoprazole), the mean RSI score changed from 22.94±5.83 to 11.19±2.97 at 12 weeks of PPI therapy. The mean RFS score changed from 12.93±3.55 to 6.86±2.86 at 12 weeks of PPI therapy. The change in the RFS and RSI score was highly significant (p=0.001). Conclusions: LPR is a common condition presenting in ENT settings, the symptoms and signs of which may be complex. RFS and RSI score are valuable tools for diagnosing LPR. PPIs are proven to be effective therapy for LPR, more studies are encouraged to affirm the efficacy of PPIs over other management options.
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