作为中枢神经系统神经变性生物标志物来源的泪液

N. Chesnokova, T. Pavlenko, O. Beznos, M. R. Nodel
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引用次数: 0

摘要

泪液的成分不仅在眼部疾病中会发生变化,在包括中枢神经系统(CNS)疾病在内的全身病理过程中也会发生变化。这是因为在中枢神经系统的积极参与下,泪液分泌的调节途径多种多样。本综述介绍了有关泪液分泌调节机制、泪液中代谢物的来源、阿尔茨海默氏症和帕金森氏症、多发性硬化症和肌萎缩侧索硬化症中泪液成分改变的数据。这些神经退行性疾病伴随着不同蛋白质生物调节剂(细胞因子、生长因子、突触核蛋白等)和儿茶酚胺浓度的典型变化。这些变化往往与脑脊液中的变化相关,甚至在疾病出现临床表现之前就已出现。因此,泪液分析是一种很有前景的非侵入性方法,可用于神经退行性疾病的早期诊断、预后和监测,以及个性化治疗。近年来,人们对这一问题的兴趣与日俱增,因此我们试图提供最新的数据,同时也提供我们自己的数据。
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Tear fluid as a source of biomarkers for the neurodegeneration in central nervous system
Composition of tear fluid alter not only in ocular diseases but in systemic pathologic processes including central nervous system (CNS) disorders. It is due to the variety of regulatory pathways for the tear production with active participation of CNS. The review represent data about mechanisms of tear production regulation, sources of metabolites present in tears, alterations of tear fluid composition in Alzheimer’s and Parkinson diseases, multiple sclerosis and amyotrophic lateral sclerosis. These neurodegenerative diseases are accompanied by typical alteration of concentrations of different protein bioregulators (cytokines, growth factors, synucleins, etc.) and catecholamines. These alterations often correlate with ones in cerebrospinal fluid appearing even before the clinical manifestation of the disease. Thus tear fluid analyses is a promising non-invasive method for the early diagnostic, prognosis and monitoring of neurodegenerative diseases, and also for the personalized therapy. We tried to represent the most recent data because interest to this problem has increased during the last years, and our own data also.
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来源期刊
Russian Neurological Journal
Russian Neurological Journal Medicine-Neurology (clinical)
CiteScore
0.40
自引率
0.00%
发文量
49
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