肝细胞癌表现为肿瘤血栓从门静脉经下腔静脉延伸至右心房,化疗栓塞治疗:罕见病例报告

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Journal of Health and Allied Sciences NU Pub Date : 2023-11-22 DOI:10.1055/s-0043-1777020
Kashish Khurana, Saket Toshniwal, Nikhil Pantbalekundri, Sunil Kumar, S. Acharya
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引用次数: 0

摘要

摘要 因肝细胞癌(HCC)导致门静脉肿瘤血栓形成的患者并不多见,其中大多数被认为是预后不良的晚期患者。血管内肿瘤血栓可能会影响右心房和下腔静脉,后者的预后较差。门静脉受累是 HCC 最严重的后果之一。无论是全身治疗还是局部治疗,针对 HCC 级联反应的多种途径,混合使用药物和其他方式,如经动脉化疗栓塞、经动脉放射栓塞、放射治疗和肝动脉灌注化疗,似乎都有帮助。门静脉肿瘤血栓形成影响 35% 到 50% 的患者,是预后不良的有力预测因素,因为肿瘤更有可能迁移到血液中,从而增加复发风险。本病例报告重点介绍了一位60岁女性患者,她患有门静脉肿瘤血栓,不愿意接受化疗和放疗,作为一种姑息治疗方法,她成功地接受了经动脉化疗栓塞治疗。
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Hepatocellular Carcinoma Presenting as Extension of Tumor Thrombus into the Right Atrium from the Portal Vein through Inferior Vena Cava Treated with Chemoembolization: A Rare Case Report
Abstract Patients with tumor thrombosis in the portal vein due to hepatocellular carcinoma (HCC) are uncommon, and the majority of these cases is thought to be in an advanced stage with a bad prognosis. The right atrium and the inferior vena cava may be impacted by the intravascular tumor thrombus, with the latter having a bad prognosis. Portal vein involvement is one of the most serious consequences of HCC. For both systemic and locoregional therapy, targeting many pathways in the HCC cascade using a mix of medications and additional modalities like transarterial chemoembolization, transarterial radioembolization, radiation, and hepatic arterial infusion chemotherapy appears to be helpful. Portal vein tumor thrombosis, which affects 35 to 50% of patients, is a strong predictor of poor prognosis due to the higher likelihood of tumor migration into the bloodstream and the subsequent increased risk of recurrence. This case report highlights about a 60-year-old female who presented with HCC with portal vein tumor thrombosis not willing for chemo- and radiotherapy successfully treated with transarterial chemoembolization as a palliative management.
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Journal of Health and Allied Sciences NU
Journal of Health and Allied Sciences NU MEDICINE, GENERAL & INTERNAL-
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