原发性腹膜后肉瘤的临床特征和治疗:文献综述

IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Annals of Gastroenterological Surgery Pub Date : 2023-11-16 DOI:10.1002/ags3.12756
Yukinori Yamagata, Motokiyo Komiyama, Shintaro Iwata
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引用次数: 0

摘要

腹膜后肉瘤(RPS)是一种罕见肿瘤,可分为多种组织学类型。它通常在肿瘤长到相当大时才被发现,需要对周围器官进行大面积切除,因此很难为患者提供最佳的治疗方案。由于其罕见性,支持 RPS 特定治疗方式的证据不足。日本于 2021 年 12 月发布了 RPS 临床实践指南,旨在积累现有证据并指出 RPS 的最佳治疗方法。这些指南提供了有关 RPS 诊断和治疗的重要临床问题(CQs)。本综述特别关注原发性 RPS,试图介绍 RPS 诊断和治疗中的临床问题,并结合指南中的 CQs 对这些问题进行评估。根据这些指南,虽然化疗和放疗有望产生治疗效果,但目前支持这些治疗的证据水平并不高。因此,完全切除肿瘤是治疗原发性 RPS 的首要和唯一选择。然而,与其他肿瘤一样,RPS 的多学科治疗需求也在不断增加。这些指南无疑将成为未来 RPS 临床实践的一个里程碑,并有望在已提出的 CQs 基础上积累更多证据。
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Clinical characteristics and management of primary retroperitoneal sarcoma: A literature review

Retroperitoneal sarcoma (RPS) is a rare tumor classified into many histological types. It is also often detected only after it has grown to a considerable size and requires extensive resection of the surrounding organs, making it difficult to offer optimal patient-tailored management. Evidence supporting specific treatment modalities for RPS is insufficient, owing to its rarity. The Japanese clinical practice guidelines for RPS were published in December 2021, with the aim of accumulating existing evidence and indicating the optimal practice for RPS. These guidelines provide important clinical questions (CQs) concerning the diagnosis and treatment of RPS. This review, with a particular focus on primary RPS, attempts to introduce clinical problems in the diagnosis and treatment of RPS and to assess those problems along with the CQs in the guidelines. According to these guidelines, although chemotherapy and radiotherapy are expected to have therapeutic effects, the level of evidence to support these treatments is not very high at present. Accordingly, complete resection of the tumor is the first and only option for managing primary RPS. However, as with other tumors, the demand for multidisciplinary treatment for RPS is increasing. These guidelines will undoubtedly represent a milestone in clinical practice in relation to RPS in the future, and further evidence is expected to be accumulated based on the CQs that have been proposed.

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来源期刊
Annals of Gastroenterological Surgery
Annals of Gastroenterological Surgery GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.30
自引率
11.10%
发文量
98
审稿时长
11 weeks
期刊最新文献
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