草药新型传输系统的前瞻性方法,特别是草药纳米科学

IF 0.3 Q4 PHARMACOLOGY & PHARMACY Current Drug Therapy Pub Date : 2023-11-16 DOI:10.2174/0115748855269312231110114359
Kartikay Prakash, Shashank Tiwari
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引用次数: 0

摘要

植物的药用和烹饪用途可以追溯到几个世纪以前。全球规模的项目正在进行实验室研究,以确定具有治疗特性的植物,最终目标是将这些化合物开发成具有可接受的给药机制的药物,并将其推向市场。从植物或草药中提取的非合成药物因其耐受性强、药物不良反应发生率低而备受关注。有一种理论认为,所有疾病都可以通过自然界中的某些东西治愈。药物的服用形式多种多样,包括片剂、胶囊、粉末、半液体提取物、酊剂、煎剂、药茶、溶液等。由于需要更长的释放时间、患者的依从性和其他目标,有必要对草药进行调整。由于缺乏科学验证,以及加工、标准化、提取和鉴定草药所固有的挑战,新型给药系统的研究人员一直忽视草药。跨学科研究和最先进的分离、纯化和鉴定技术促使了新型草药成分的开发。生物活性植物提取物和植物成分被广泛应用于纳米乳剂、微球、转移体、植入体和乙素体。与草药相比,新型制剂的效果更好。这些优势包括更高的溶解度、生物利用度、毒性、药理活性、稳定性、给药时间以及耐物理和化学降解性。因此,使用新型给药系统可以提高中草药的药代动力学和药效学特性,使其更安全、更有效。本文旨在简明扼要地介绍为给药中草药而创造的多种新型给药技术。最终目的是提高疗法的疗效,并进一步了解其意义和全球吸引力。
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Prospective Approaches of Herbal Novel Delivery System with Special Reference to the Herbal Nanosciences
Medicinal and culinary uses of plants date back centuries. Projects on a global scale are conducting laboratory research to identify plants with therapeutic properties, with the ultimate goal of developing such compounds into medicines with acceptable drug delivery mechanisms and bringing them to market. Non-synthetic medications derived from plant or herbal sources have attracted a lot of interest because of their high tolerability and low likelihood of adverse medication reactions. All diseases, the theory goes, can be cured by something found in nature. Medicines can be taken in a wide variety of forms, including tablets, capsules, powders, semi-liquid extracts, tinctures, decoctions, medicinal teas, solutions, and more. Longer release, patient adherence, and other objectives necessitate adjustments to herbal medications. Researchers into novel drug delivery systems had hitherto overlooked herbal remedies due to a lack of scientific validation and the challenges inherent in processing, standardizing, extracting, and identifying them. Transdisciplinary research and cuttingedge isolation, purification, and identification techniques have led to the development of novel herbal compositions. Bioactive plant extracts and phytoconstituents are used in a wide variety of Nano- Emulsions, microspheres, transferosomes, implants, and ethosomes. Compared to herbal remedies, novel formulations fared better. Among these advantages are increased solubility, bioavailability, toxicity, pharmacological activity, stability, delivery duration, and resistance to physical and chemical degradation. As a result, the pharmacokinetic and pharmacodynamic properties of herbal medications can be enhanced by the use of novel drug delivery systems, making them safer and more effective. This article aims to provide a concise description of the many new drug delivery techniques that have been created for the administration of herbal medications. The ultimate goal is to increase the efficacy of therapies and to learn more about their significance and worldwide appeal.
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来源期刊
Current Drug Therapy
Current Drug Therapy PHARMACOLOGY & PHARMACY-
CiteScore
1.30
自引率
0.00%
发文量
50
期刊介绍: Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.
期刊最新文献
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