分子之眼基于分子探针技术的重大临床疾病精准诊断和治疗系统

Xin Ji, Xin Chen, Kexin Li, Zhihao Zhang, Lijun Tang, Tiannv Li, Feng Han, Hao Hong* and Tao Zhang*, 
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摘要

随着精准医学的蓬勃发展,被普遍认为是诊断与治疗一体化的治疗学(theranostics)已成为临床研究的一个突出趋势。然而,治疗学主要强调的是整合的最终结果,对于如何实现精确诊断和协同个体化治疗,以及在临床实践中如何有效解决临床难题,却没有提供足够的细节。分子探针技术为弥合理论与实践之间的差距提供了强有力的方法。通过对化学结构的精心设计,成像标签或药物与肿瘤靶向肽、抗体或诱导剂共轭形成分子探针,从而实现靶向干预和靶向成像的无缝切换,并在时间、空间和生物分布上保持一致。因此,本综述提出了 "分子眼 "的概念,即基于分子探针技术的重大临床疾病精准诊断和治疗的综合体系。这一医学体系强调探针开发和优化的化学基础,可为临床决策提供精确的可操作信息,实现分子靶向治疗,扩大旧疗法的适应症,加速分子药物的监管审批。"分子眼 "就像孙悟空的火眼金睛,能发现以前 "看不见 "的疾病,便于疾病诊断、治疗、实时评估和病理研究,指导药物研发。分子眼 "的出现将为临床实践和医学研究领域带来机遇和挑战,推动当代医学向精准医学迈进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Molecular Eye: A System for Precise Diagnosis and Treatment of Major Clinical Diseases Based on Molecular Probe Technology

With the flourishing development of precision medicine, theranostics, generally recognized as the integration of diagnosis and treatment, has emerged as a prominent trend in clinical research. However, theranostics primarily emphasizes the end result of integration, without providing sufficient details on how precise diagnosis and synergetic individualized treatment could be achieved and what clinical challenges could be effectively addressed in clinical practice. Molecular probe technology provides a robust method to bridge the gap between theory and practice. Through meticulous design of the chemical structure, imaging labels or drugs were conjugated to tumor-targeting peptides, antibodies, or inducers to form molecular probes, which allow a seamless switch between targeted intervention and targeted imaging with consistency in time, space, and biodistribution. Thus, this review proposes a concept called “molecular eye”, which refers to a comprehensive system for precise diagnosis and treatment of major clinical diseases based on molecular probe technology. This medical system emphasizes the chemical basis of probe development and optimization, which can provide precise actionable information for clinical decision making, allow molecular-targeted therapy, expand the indications of old therapy, and accelerate the regulatory approval of molecular drugs. “Molecular eye” resembles the piercing eye of the Monkey King, which can detect previously “invisible” diseases and facilitate disease diagnosis, treatment, real-time evaluation, and pathology research, guiding drug development. The emergence of the “molecular eyes” will provide opportunities and challenges in the fields of clinical practice and medical research and propel the progression of contemporary medicine toward precision medicine.

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来源期刊
Chemical & Biomedical Imaging
Chemical & Biomedical Imaging 化学与生物成像-
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期刊介绍: Chemical & Biomedical Imaging is a peer-reviewed open access journal devoted to the publication of cutting-edge research papers on all aspects of chemical and biomedical imaging. This interdisciplinary field sits at the intersection of chemistry physics biology materials engineering and medicine. The journal aims to bring together researchers from across these disciplines to address cutting-edge challenges of fundamental research and applications.Topics of particular interest include but are not limited to:Imaging of processes and reactionsImaging of nanoscale microscale and mesoscale materialsImaging of biological interactions and interfacesSingle-molecule and cellular imagingWhole-organ and whole-body imagingMolecular imaging probes and contrast agentsBioluminescence chemiluminescence and electrochemiluminescence imagingNanophotonics and imagingChemical tools for new imaging modalitiesChemical and imaging techniques in diagnosis and therapyImaging-guided drug deliveryAI and machine learning assisted imaging
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