www.JPPN.ru, N. Shnayder, Alla V. Kidyaeva, E. Vaiman, A. Asadullin, Marina M Petrova, D. S. Kaskaeva, Gennady V. Matyushin, Aleksandr A. Evsyukov, Elena V. Galko, N. Garganeeva, Galina A Chumakova, N. Lareva, Nikolai G. Neznanov, Regina F. Nasyrova, В. .. Presynaptic, Monoamine Reuptake, Nonselective Presynaptic Monoamine, Reuptake, Tricyclic Antidepressants
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引用次数: 0
摘要
抗抑郁药(ADs)包括不同药理类别的药物,主要用于治疗精神障碍(重度抑郁症、强迫症、社交恐惧症、恐慌症、广泛性焦虑症、创伤后应激障碍)、慢性疼痛和成瘾性疾病。长期服用抗抑郁药会导致心脏毒性药物不良反应(ADR)的发生。最重要的心脏毒性 AD 引起的不良反应是 QT 间期延长、"回旋 "型室性心动过速(Torsades de Pointes - TdP)。这篇叙述性综述分析并总结了有关抗抑郁药对 QT 间期延长的药代动力学和药物遗传学的研究结果,并更新了医生对精神疾病患者发生抗抑郁药所致 TdP 风险的认识。
Role of Pharmacokinetics and Pharmacogenetics of Antidepressant-Induced Prolongation of the QT Interval and Torsade de Pointes in Patients with Mental Disorders
Antidepressants (ADs) include drugs of various pharmacological groups, which are mainly used for the treatment of mental disorders (major depressive disorder, obsessive-compulsive disorder, social phobia, panic disorder, generalized anxiety disorder, post-traumatic stress disorder), chronic pain and addiction diseases. Chronic use of ADs can lead to the development of cardiotoxic adverse drug reactions (ADRs). The most important cardiotoxic AD-induced ADRs are prolongation of the QT interval, ventricular tachycardia of the "pirouette" type (Torsades de Pointes - TdP). This narrative review analyzes and summarizes the results of studies on pharmacokinecis and pharmacogenetics of ADs on QT interval prolongation and updates physicians' knowledge of the risk of developing AD-induced TdP in patients with psychiatric disorders.