改变游戏规则的基因工程项目简介

Poulami Khan, Saheli Basu Roy
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摘要

近年来,研究的进步明显涉及到对大规模基因组和后基因组数据集的计算管理。在高通量技术和基因组规模数据库的推动下,迅速崛起的生物信息学领域被认为将把我们的研究方法重塑到一个新的水平。基因组学改变了生物学的研究范式,探索了许多领域。旧的倡议为更新、更有利的倡议铺平了道路。本综述侧重于目前正在实施的计划,如著名的人类基因组计划及其对数字生物学的影响,以及紧随其后的项目。此外,作者还深入探讨了个性化医疗的未来潜力,以及基因编辑中 CRISPR/Cas9 等基因工程方法的使用,这些方法被认为有可能彻底改变当前的治疗策略。
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A brief overview of game-changing genetic engineering projects
In recent era, advancement of research involves computational management of large-scale genomic and post-genomic datasets in an obvious way. Rapidly emerging field of bioinformatics, fueled by high-throughput technologies and genomic scale database, is believed to reshape our approach of research to a new level. Genomics has shifted the paradigm of biological perspectives exploring many scopes. Old initiatives paved the path for the newer and more advantageous one. The present review focuses on present initiatives that are implemented till now like the famous Human Genome Project and its influence on digital biology, as well as the projects that followed in its footsteps. Additionally, the authors delve into the future potential of personalized medicine and the use of genetic engineering methods like CRISPR/Cas9 in gene editing, which are thought to have the potential to revolutionize the current treatment strategy.
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