使用空心纳米球早期检测癌胚抗原可改善小儿实体瘤的治疗效果

IF 2.9 4区 医学 Q1 Medicine Journal of biomedical nanotechnology Pub Date : 2023-11-01 DOI:10.1166/jbn.2023.3619
Jiansheng Hu, Danli Sun, Qinhui Feng, Liang Wei, Wucai Liu
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引用次数: 0

摘要

以空心纳米球复合材料加载金纳米粒子作为信号标签,以金三角纳米板作为基底材料,开发了一种夹心电化学免疫传感器,用于灵敏检测癌胚抗原(CEA)。从小儿实体瘤组织及其血液样本中提取的样本被用于使用这种纳米颗粒检测 CEA。本研究中构建的空心纳米球提供了丰富的反应位点和高催化活性,而金纳米颗粒的负载则增强了导电性和生物相容性。该免疫传感器具有良好的分析能力,可在 1 pg/mL 至 50 ng/mL 的质量浓度范围内检测 CEA,检出限(LOD)低至 0.37 pg/mL。这种新型方法为临床快速检测小儿实体瘤中的 CEA 提供了一种有价值的工具。
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Early Detection of Carcinoembryonic Antigen Using Hollow Nanospheres Improves the Outcome of Pediatric Solid Tumors
A sandwich electrochemical immunosensor was developed for sensitive detection of carcinoembryonic antigen (CEA) using hollow nanospheres composite material loaded with gold nanoparticles as the signal tag and gold triangular nanoplate as the substrate material. Samples obtained from pediatric solid tumor tissue and their blood samples were used to detect CEA using this nanoparticle. The hollow nanospheres constructed in this study, provided abundant reaction sites and high catalytic activity, while the loading of Au NPs enhances conductivity and biocompatibility. The immunosensor has good analytical ability in detecting CEA in the mass concentration range of 1 pg/mL to 50 ng/mL, with a low detection limit (LOD) of 0.37 pg/mL. This novel method provides a valuable tool for rapid clinical detection of CEA in the context of pediatric solid tumors.
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来源期刊
CiteScore
4.30
自引率
17.20%
发文量
145
审稿时长
2.3 months
期刊介绍: Information not localized
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