{"title":"建立和验证测定某些精油中氟康唑的新可见分光光度法","authors":"Ioana OLARIU","doi":"10.31925/farmacia.2023.5.19","DOIUrl":null,"url":null,"abstract":"This study aimed to develop and validate a visible spectrophotometry analysis method for fluconazole quantification in the presence of some essential oils (cinnamon, oregano and clove essential oil), by forming a coloured complex with Cu 2+ ion. For the spectrophotometric method validation the spectra of the fluconazole-Cu(II) complex in the presence of volatile oils were analysed and the wavelengths corresponding to the maximum absorbance values of the complex were determined. Evaluating the precision, linearity, accuracy and robustness of the elaborated visible spectrophotometric method, the obtained values of the specific parameters fell within the limits provided by the standards in force. Linearity was very good for the following fluconazole concentration ranges: 0.268 - 2.68 mg/mL for oregano essential oil, 0.2073 - 2.073 mg/mL for cinnamon essential oil and 0.2317 - 2.317 mg/mL in the case of clove essential oil. The proposed visible spectrophotometric method has been successfully applied for the assay of fluconazole in clove, cinnamon and oregano essential oils","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"DEVELOPMENT AND VALIDATION OF A NEW VISIBLE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF FLUCONAZOLE IN THE PRESENCE OF SOME ESSENTIAL OILS\",\"authors\":\"Ioana OLARIU\",\"doi\":\"10.31925/farmacia.2023.5.19\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study aimed to develop and validate a visible spectrophotometry analysis method for fluconazole quantification in the presence of some essential oils (cinnamon, oregano and clove essential oil), by forming a coloured complex with Cu 2+ ion. For the spectrophotometric method validation the spectra of the fluconazole-Cu(II) complex in the presence of volatile oils were analysed and the wavelengths corresponding to the maximum absorbance values of the complex were determined. Evaluating the precision, linearity, accuracy and robustness of the elaborated visible spectrophotometric method, the obtained values of the specific parameters fell within the limits provided by the standards in force. Linearity was very good for the following fluconazole concentration ranges: 0.268 - 2.68 mg/mL for oregano essential oil, 0.2073 - 2.073 mg/mL for cinnamon essential oil and 0.2317 - 2.317 mg/mL in the case of clove essential oil. The proposed visible spectrophotometric method has been successfully applied for the assay of fluconazole in clove, cinnamon and oregano essential oils\",\"PeriodicalId\":12344,\"journal\":{\"name\":\"FARMACIA\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2023-10-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"FARMACIA\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.31925/farmacia.2023.5.19\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"FARMACIA","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.31925/farmacia.2023.5.19","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
DEVELOPMENT AND VALIDATION OF A NEW VISIBLE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF FLUCONAZOLE IN THE PRESENCE OF SOME ESSENTIAL OILS
This study aimed to develop and validate a visible spectrophotometry analysis method for fluconazole quantification in the presence of some essential oils (cinnamon, oregano and clove essential oil), by forming a coloured complex with Cu 2+ ion. For the spectrophotometric method validation the spectra of the fluconazole-Cu(II) complex in the presence of volatile oils were analysed and the wavelengths corresponding to the maximum absorbance values of the complex were determined. Evaluating the precision, linearity, accuracy and robustness of the elaborated visible spectrophotometric method, the obtained values of the specific parameters fell within the limits provided by the standards in force. Linearity was very good for the following fluconazole concentration ranges: 0.268 - 2.68 mg/mL for oregano essential oil, 0.2073 - 2.073 mg/mL for cinnamon essential oil and 0.2317 - 2.317 mg/mL in the case of clove essential oil. The proposed visible spectrophotometric method has been successfully applied for the assay of fluconazole in clove, cinnamon and oregano essential oils
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FARMACIA publishes original research papers, invited topical reviews and editorial commentaries and news, with emphasis on conceptual novelty and scientific quality. Main research areas are focused on: pharmacology, toxicology, medicinal chemistry, biopharmacy, drug design, drug delivery, personalized medicine, nanostructures, nutraceuticals, biochemistry and biotechnology. Manuscripts submitted to the Journal are only accepted after the peer review precess. The papers should have not been published in any other journal. The recommendations of the Declaration of Helsinki, for humans, and the International guidelines as accepted principles for the use of experimental animals should be followed.
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