子宫肌瘤的血清疗法:现状与未来

О.С. Салех, D. Zhelezov, I. Hladchuk, A. Volyanska
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引用次数: 0

摘要

研究目的:在考虑表观遗传调控状态的基础上,开发一种预测子宫肌瘤生长的算法。该研究是在2018-2021年妇产科临床分科的基础上进行的。对28例子宫肌瘤患者进行了检查。利用实时PCR技术测定了所有女性肿瘤组织中miRNA-29b和miRNA-146a的表达情况。获得的数据使用 Statistica 10.0 统计程序(StatSoft Inc.患者的平均年龄为 39.3 ± 1.0 岁。平均结节数为 2.7 ± 0.4。在大多数受检组织样本中,microRNA-29b 的表达水平通常在 2-7 个单位之间,microRNA-146a 的表达水平通常在 30-67 个单位之间。miRNA-29b 的表达对生长预测的意义最大(Wald 统计)。根据逻辑回归方程,预后因素包括患者的年龄、月经周期 I 期和 II 期的雌二醇和孕酮水平、最大结节的直径、miRNA-29b 和 miRNA-146a 的表达。这项研究表明,使用 miRNA 表达谱作为诊断和治疗子宫肌瘤的额外标志物很有前景,但还需要更详细的研究。进一步研究临床和辅助临床参数的相关性,可以预测子宫肌瘤的病程,从而制定有效的个性化治疗方案。Theranostics 是一种诊断和治疗病人的新方法,它以每个人的独特性为基础,以便在分子遗传技术的背景下选择最佳治疗策略,特别是确定过度增殖性疾病的表观遗传变化。未来,miRNA 表达研究可能会在子宫肌瘤的治疗学中占有一席之地。
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Theranostics of uterine leiomyoma: present and future
Research objectives: to develop an algorithm for predicting the growth of uterine fibrodis, taking into account the state of epigenetic regulation.Materials and methods. The study was conducted on the basis of clinical divisions of the Department of Obstetrics and Gynecology in 2018–2021. 28 patients with uterine fibroids were examined. Expression of miRNA-29b and miRNA-146a in tumor tissue was determined in all women using real-time PCR. Obtained data were analyzed using the statistical program Statistica 10.0 (StatSoft Inc., USA).Results. The average age of the patients was 39.3 ± 1.0 years. The average number of nodes was 2.7 ± 0.4. The expression levels of microRNA-29b were most frequently determined in the range of 2–7 units and microRNA-146a in the range of 30–67 units in most of the examined tissue samples. The expression of miRNA-29b has the greatest significance for the growth forecast (Wald statistic). According to the logistic regression equation the prognostic factors are patient’s age, estradiol and progesterone level in the I and II phases of the menstrual cycle, diameter of the largest node, expression of miRNA-29b and miRNA-146a.Conclusions. This study shows that the use of miRNA expression profile as an additional marker in the diagnosis and treatment of uterine fibroids is promising and requires more detailed research. Further study of the correlation of clinical and paraclinical parameters can make it possible to predict the course of uterine fibroids, and therefore to apply an effective personalized treatment plan. Theranostics is a new approach to the diagnosis and treatment of patients, based on the uniqueness of each person in order to choose the optimal treatment strategy against the background of the molecular genetic technologies, in particular to determine epigenetic changes in hyperproliferative diseases. The study of miRNA expression may find its place in the theranostics of uterine fibroids in the future.
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来源期刊
Reproductive Endocrinology
Reproductive Endocrinology Medicine-Obstetrics and Gynecology
CiteScore
0.50
自引率
0.00%
发文量
13
审稿时长
8 weeks
期刊最新文献
Analysis of differential expression of genes of structural and regulatory proteins of connective tissue as factors associated with the vaginal prolapse Protection of reproductive health of children: problems of gender and age discrimination Use of progestagens to preserve pregnancy: modern approaches Resolution of the IV International Menopause Expert Forum Theranostics of uterine leiomyoma: present and future
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