大麻植物的治疗潜力

Siddhesh Pote, Parul Khurana, Gaganjyot Kaur, Sonali Kokane
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引用次数: 0

摘要

本综述文章旨在概述大麻植物在治疗人类疾病方面的作用。本综述强调大麻素--其衍生物和合成类似物--作为一种活性药物成分,可治疗与人体自身免疫反应有关的疾病。内源性大麻素系统 CB1 和 CB2 对大麻二酚、四氢大麻酚和萜烯等各种植物化学物质的反应各不相同。它们还与人体合成的内源性配体相互作用。本综述讨论了纳米技术在设计给药系统中的作用。还简要介绍了使用量子点的优势。以大麻为基础的植物化学物质具有精神和非精神作用。我们强调了这种植物在治疗疾病方面的巨大潜力。大麻二酚(CBD)作为主要的非精神类植物化学物质之一,已成为世界上一些获批药物中的活性药剂。以大麻为基础的植物化学物质可用作靶向给药载体。这一领域的未来发展方向可能是合成大麻二酚的衍生物,并将其作为靶向药物输送到大麻素受体。在口服途径中,萜烯类物质带来了健康的大麻消费体验。
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Therapeutic Potential of Cannabis Plant
The aim of this review article is to outline the role of the plant Cannabis sativa in treating human ailments. Giant pharmaceuticalcompanies are marketing phytochemicals extracted from Cannabis plant and its derivatives to treat epilepsy and multiple sclerosis.The present review emphasizes cannabinoids – its derivatives and synthetic analogs – as an active pharmaceutical Ingredient to treatailments related to autoimmune human body responses. The endocannabinoid system CB1 and CB2 respond differently to variousphytochemicals such as cannabidiol, tetrahydrocannabinol and terpenes. They also interact with the endogenous ligands synthesized bythe human body. The role of nanotechnology in the design of a drug delivery system is discussed in this review. The advantages with theuse of Quantum dots are briefly outlined. Cannabis-based phytochemicals are known for psychotic and non-psychotic effects. We haveunderlined the immense potential of this plant in treating diseases. Cannabidiol (CBD) as one of the main non-psychotic phytochemicals,has established itself as an active pharmaceutical agent in some approved medicines worldwide. Cannabis-based phytochemicals can beused as targeted drug delivery vehicles. Future direction in this field could be a synthesis of derivatives of cannabidiol and its targeteddrug delivery to the cannabinoid receptors. In the oral route, the terpenes give the wholesome experience of consuming Cannabis.
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