alocasia odora K. Koch 根茎的植物化学研究和抗菌活性

Nguyen Thi Hai Ha, Nguyen Van Tuyen, N. Son, L. Anh, Nguyen Thi Thuy Linh, Pham Minh Quan, Le Thi Hai Yen, Nguyen Van Du
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引用次数: 0

摘要

Alocasia odora 是越南常见的植物物种。对在 Tuyen Quang 省采集到的 Alocasia odora 根茎乙酸乙酯提取物(EtOAc)进行的植物化学调查分离并测定了五种化合物,包括三种生物碱 alocasin A (1)、hyrtiosin B (2)、hyrtiosulawesine (3),一种单酚 p-hydroxycinamic acid (4) 和一种脂肪酸 myristic acid (5)。通过一维和二维核磁共振光谱、质谱数据确定了这些化合物的化学结构,并与文献中报道的结构进行了比较。使用肉汤微稀释法评估了生物碱对微生物的抗菌活性,结果表明生物碱 1 - 3 对参考菌株具有抗菌活性,MIC 值在 8 µg/mL 至 128 µg/mL 之间,其中化合物 1 的活性最高,MIC 值在 8 µg/mL 至 32 µg/mL 之间。化合物 4-5 在研究浓度(MIC > 128 µg/mL)下没有显示出抗菌活性。这是首次报道 A. odora 的抗菌效果。
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Phytochemical investigation and antimicrobial activity from rhizomes of alocasia odora K. Koch
Alocasia odora is a common plant species in Viet Nam. A phytochemical investigation of the ethyl acetate extract (EtOAc) of A. odora rhizomes collected in Tuyen Quang province led to the isolation and determination of five compounds, including three alkaloids, alocasin A (1), hyrtiosin B (2), hyrtiosulawesine (3), one mono-phenol, p-hydroxycinamic acid (4), and one fatty acid, myristic acid (5). The chemical structures of those compounds were determined by 1D and 2D-NMR spectroscopic, MS data and compared with those reported in the literature. Antimicrobial activity against microorganisms was evaluated using the broth microdilution method, showing that alkaloids 1 - 3 exhibited antimicrobial activity against reference strains with MIC values ranging from 8 µg/mL to 128 µg/mL, in which compound 1 was the most active with MIC values calculated between 8 µg/mL and 32 µg/mL. Compound 4-5 did not display antimicrobial activity at the studied concentration, MIC > 128 µg/mL. This is the first time the antimicrobial effect of A. odora has been reported.
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