CHIRAL SEPARATION OF $(2S,~9S)$-DIAMINO-2,9-DIBENZYLDECA-4,6-DIYNEDIOIC ACID AND $(2R,~9R)$-DIAMINO-2,9-DIBENZYLDECA-4,6-DIYNEDIOIC ACID

The enantiomers of the chiral compound (2S, 9S)-diamino-2,9-dibenzyldeca-4,6-diynedioic acid and (2R, 9R)-diamino-2,9-dibenzyldeca-4,6-diynedioic acid were separated by a chiral high-performance liquid chromatography (HPLC) method. The separation of α-amino acids was performed using a 5µ 4.0×250 mm column, which was obtained on the basis of a sorbent with eremomycin. The sorbent is silica gel (with 11 nm pore diameter and a surface area of 300 m2/g) with epoxy groups grafted on them with antibiotic eremomycin. Chiral HPLC is one of the most common methods for separating enantiomers of chiral compounds. Synthesis of new pharmaceutical substances, which are one of the isomers of a substance, obtaining of new drugs based on them, as well as the need to control the presence of the second isomer in such drugs, impose new requirements on the modern chromat-ographic separation of isomers.