Pub Date : 2023-11-03DOI: 10.46991/pysu:b/2023.57.3.199
Liana S. Gabrielyan, Z. Papanyan
A detailed conformational analysis of ethyl methyl sulfone has been carried out using quantum chemical approaches, by revealing all stable conformers, their energy, structural parameters, relative population, and IR spectra at different levels of theory. Thermochemical parameters, such as energy, entropy and heat capacity of ethyl methyl sulfone stable conformers in the gas phase were calculated directly using the wB97XD/6-311++G(2df, 2pd) density functional theory method. Some correlation has been established between the structural characteristics of various conformers and their thermodynamic properties.
{"title":"QUANTUM CHEMICAL CALCULATION OF STRUCTURAL AND THERMODYNAMIC PROPERTIES OF ETHYL METHYL SULFONE IN THE GAS PHASE","authors":"Liana S. Gabrielyan, Z. Papanyan","doi":"10.46991/pysu:b/2023.57.3.199","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.3.199","url":null,"abstract":"A detailed conformational analysis of ethyl methyl sulfone has been carried out using quantum chemical approaches, by revealing all stable conformers, their energy, structural parameters, relative population, and IR spectra at different levels of theory. Thermochemical parameters, such as energy, entropy and heat capacity of ethyl methyl sulfone stable conformers in the gas phase were calculated directly using the wB97XD/6-311++G(2df, 2pd) density functional theory method. Some correlation has been established between the structural characteristics of various conformers and their thermodynamic properties.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139289969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.46991/pysu:b/2023.57.3.222
S. Badalyan, N. Gharibyan
Many species of the genus Pleurotus (Fr.) P. Kumm. (Oyster mushrooms) are known as valuable edible and medicinal fungi, cultivated worldwide. The studied 18 different collections of five Pleurotus species (P. ostreatus, P. cornucopiae, P. eryngii, P. pulmonarius, and P. cystidiosus) during submerged growth in malt extract medium formed round shaped fluffy pellets and disperse mycelium. After seven days of cultivation, they accumulated up to 29.46 g/L biomass, while after 14 days the amount increased up to 40.4 g/L, reaching the value of commercial P. ostreatus 22 strain. More than 30.0 g/L biomass was formed in nine from 12 P. ostreatus collections, among which Armenian (SB24 and SB25), French (Po/28) and Spanish (N001) strains, as ecologically safe resources are perspective for further study to develop mushroom-based biotech products, food, pharmaceuticals and cosmeceticals.
{"title":"BIOMASS FORMATION BY DIFFERENT COLLECTIONS OF $PLEUROTUS$ SPP. DURING SUBMERGED GROWTH","authors":"S. Badalyan, N. Gharibyan","doi":"10.46991/pysu:b/2023.57.3.222","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.3.222","url":null,"abstract":"Many species of the genus Pleurotus (Fr.) P. Kumm. (Oyster mushrooms) are known as valuable edible and medicinal fungi, cultivated worldwide. The studied 18 different collections of five Pleurotus species (P. ostreatus, P. cornucopiae, P. eryngii, P. pulmonarius, and P. cystidiosus) during submerged growth in malt extract medium formed round shaped fluffy pellets and disperse mycelium. After seven days of cultivation, they accumulated up to 29.46 g/L biomass, while after 14 days the amount increased up to 40.4 g/L, reaching the value of commercial P. ostreatus 22 strain. More than 30.0 g/L biomass was formed in nine from 12 P. ostreatus collections, among which Armenian (SB24 and SB25), French (Po/28) and Spanish (N001) strains, as ecologically safe resources are perspective for further study to develop mushroom-based biotech products, food, pharmaceuticals and cosmeceticals.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139323345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.46991/pysu:b/2023.57.3.214
A. Antonyan, Zvart O. Movsisyan, Anzhela H. Karapetyan, P. Vardevanyan
Interaction of ethidium bromide (EtBr), acridine orange (AO) and non-intercalator methylene blue (MB) with DNA as well as interaction of EtBr and MB with single-stranded synthetic polynucleotides poly(rA) and poly(rU) have been studied. It was revealed that in absorption spectra of EtBr and MB with DNA or single-stranded polynucleotides a real- or pseudo-isosbestic point appears. Particularly, in absorption spectra of the complexes of classical intercalator EtBr with DNA the real isosbestic point is formed, but in the case of non-classical intercalator MB a pseudo-isosbestic point is formed, while in the absorption spectra of their complexes with single-stranded polynucleotides a pseudo-isosbestic point is formed. It was found out that for another classical intercalator AO there is no a real or pseudo-isosbestic point.
研究了溴化乙锭（EtBr）、吖啶橙（AO）和非交联剂亚甲基蓝（MB）与 DNA 的相互作用，以及 EtBr 和 MB 与单链合成多核苷酸 poly(rA) 和 poly(rU) 的相互作用。研究发现，在 EtBr 和甲基溴与 DNA 或单链多核苷酸的吸收光谱中，会出现一个实性或假性异色点。特别是，在经典插入剂 EtBr 与 DNA 的复合物的吸收光谱中，形成了真等距点，但在非经典插入剂 MB 的情况下，形成了假等距点，而在它们与单链多核苷酸的复合物的吸收光谱中，形成了假等距点。研究发现，另一种经典插入剂 AO 不存在真实或假性异斯巴达点。
{"title":"SPECTROPHOTOMETRIC STUDY OF COMPLEXES OF SOME INTERCALATORS WITH DOUBLE-STRANDED AND SINGLE-STRANDED NUCLEIC ACIDS","authors":"A. Antonyan, Zvart O. Movsisyan, Anzhela H. Karapetyan, P. Vardevanyan","doi":"10.46991/pysu:b/2023.57.3.214","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.3.214","url":null,"abstract":"Interaction of ethidium bromide (EtBr), acridine orange (AO) and non-intercalator methylene blue (MB) with DNA as well as interaction of EtBr and MB with single-stranded synthetic polynucleotides poly(rA) and poly(rU) have been studied. It was revealed that in absorption spectra of EtBr and MB with DNA or single-stranded polynucleotides a real- or pseudo-isosbestic point appears. Particularly, in absorption spectra of the complexes of classical intercalator EtBr with DNA the real isosbestic point is formed, but in the case of non-classical intercalator MB a pseudo-isosbestic point is formed, while in the absorption spectra of their complexes with single-stranded polynucleotides a pseudo-isosbestic point is formed. It was found out that for another classical intercalator AO there is no a real or pseudo-isosbestic point.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139322951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.46991/pysu:b/2023.57.3.190
M. Torosyan, Narine K. Durgaryan
In the field of food safety, sensors are widely used for the detection and determination of a wide variety of volatile compounds. This work presents the synthesis of a number of polyaniline analog polymers and the study of their properties as such sensors. In the course of the work, the design and preparation of carriers for polymers with sensor properties was carried out and, based on it, a new method for measuring and recording changes in the electrical conductivity of insoluble polymers in the presence of volatile substances was developed. The applicability of the developed method was verified.
{"title":"CONDUCTIVE POLYMERS AS MATERIALS USED IN SENSORS FOR DETERMINATION OF IMPORTANT VOLATILE COMPOUNDS IN THE FIELD OF FOOD SAFETY","authors":"M. Torosyan, Narine K. Durgaryan","doi":"10.46991/pysu:b/2023.57.3.190","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.3.190","url":null,"abstract":"In the field of food safety, sensors are widely used for the detection and determination of a wide variety of volatile compounds. This work presents the synthesis of a number of polyaniline analog polymers and the study of their properties as such sensors. In the course of the work, the design and preparation of carriers for polymers with sensor properties was carried out and, based on it, a new method for measuring and recording changes in the electrical conductivity of insoluble polymers in the presence of volatile substances was developed. The applicability of the developed method was verified.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139337250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-15DOI: 10.46991/pysu:b/2023.57.3.182
V.V. Vardapetyan, M. Torosyan, G. A. Shahinyan, A. I. Martiryan
In this work, several varieties of instant and ground, roasted black packaged coffee were studied. Various extraction methods were used to obtain extracts. The caffeine content was investigated by UV-Vis absorption spectroscopy and HPLC chromatography. The antioxidant properties of the extracts were studied by the method of competitive reactions.
{"title":"STUDY OF ANTIOXIDANT PROPERTIES OF SOME TYPES OF PACKAGED COFFEE","authors":"V.V. Vardapetyan, M. Torosyan, G. A. Shahinyan, A. I. Martiryan","doi":"10.46991/pysu:b/2023.57.3.182","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.3.182","url":null,"abstract":"In this work, several varieties of instant and ground, roasted black packaged coffee were studied. Various extraction methods were used to obtain extracts. The caffeine content was investigated by UV-Vis absorption spectroscopy and HPLC chromatography. The antioxidant properties of the extracts were studied by the method of competitive reactions.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139339710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.46991/pysu:b/2023.57.2.118
M. Mikaelyan, M. Shahinyan, M. Parsadanyan
In this work the effect of different temperatures on erythrocyte resistance has been studied. It was also examined the influence of various temperatures on optic density change of erythrocyte suspension. It was shown that there are no sharp changes of optic density values of erythrocyte suspension, based on which we assume that under the effect of the given temperatures the significant alterations are not observed, but the state of erythrocytes changes, particularly the structure of erythrocyte membranes changes. It was also revealed that the structural changes of erythrocyte membranes occur under the impact of environmental factors, including anthropogenic ones.
{"title":"ERYTHROCYTES AS A MODEL FOR STUDYING THE EFFECT OF TEMPERATURE ON THE RESISTENCE OF CELLULAR MEMBRANES","authors":"M. Mikaelyan, M. Shahinyan, M. Parsadanyan","doi":"10.46991/pysu:b/2023.57.2.118","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.2.118","url":null,"abstract":"In this work the effect of different temperatures on erythrocyte resistance has been studied. It was also examined the influence of various temperatures on optic density change of erythrocyte suspension. It was shown that there are no sharp changes of optic density values of erythrocyte suspension, based on which we assume that under the effect of the given temperatures the significant alterations are not observed, but the state of erythrocytes changes, particularly the structure of erythrocyte membranes changes. It was also revealed that the structural changes of erythrocyte membranes occur under the impact of environmental factors, including anthropogenic ones.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.46991/pysu:b/2023.57.2.164
Ani A. Harutyunyan, J. Manoyan, L. Hambaryan, L. Gabrielyan
Cyanobacteria generate biomass under photoautotrophic conditions during photosynthesis. Cultivation of cyanobacteria under photoheterotrophic conditions using various organic carbon sources can increase yield of biomass. In the current study, the effect of organic carbon sources on the growth properties and morphology of cyanobacteria Spirulina platensis, as well as the production of the photosynthetic pigments: chlorophyll a, carotenoids, and phycocyanin were investigated. Carbon sources, such as glucose, fructose and succinate, caused not only an increase in the cyanobacterial growth rate, but also morphological changes in S. platensis trichomes. An increase in the amounts of photosynthetic pigments was also observed. Thus, glucose, fructose, and succinate are more efficient substrates for photoheterotrophic cultivation of these cyanobacteria.
{"title":"EFFECT OF VARIOUS CARBON SOURCES ON THE GROWTH PROPERTIES AND MORPHOLOGY OF $SPIRULINA~PLATENSIS$","authors":"Ani A. Harutyunyan, J. Manoyan, L. Hambaryan, L. Gabrielyan","doi":"10.46991/pysu:b/2023.57.2.164","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.2.164","url":null,"abstract":"Cyanobacteria generate biomass under photoautotrophic conditions during photosynthesis. Cultivation of cyanobacteria under photoheterotrophic conditions using various organic carbon sources can increase yield of biomass. In the current study, the effect of organic carbon sources on the growth properties and morphology of cyanobacteria Spirulina platensis, as well as the production of the photosynthetic pigments: chlorophyll a, carotenoids, and phycocyanin were investigated. Carbon sources, such as glucose, fructose and succinate, caused not only an increase in the cyanobacterial growth rate, but also morphological changes in S. platensis trichomes. An increase in the amounts of photosynthetic pigments was also observed. Thus, glucose, fructose, and succinate are more efficient substrates for photoheterotrophic cultivation of these cyanobacteria.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.46991/pysu:b/2023.57.2.177
M. Torosyan, V.V. Vardapetyan, G. A. Shahinyan, A. I. Martiryan
The study of antioxidants in plants is one of the modern scientific and practical problems. The aim of this work is to obtain the extracts of pharmacy sale juniper berries and seeds, and to study their antioxidant properties by the method of competitive reactions. In this work, a number of extraction methods were used, and the investigation of the obtained extracts was performed by spectrometric and chromatographic methods.
{"title":"PREPARATION AND STUDY OF JUNIPER BERRY AND SEED EXTRACTS","authors":"M. Torosyan, V.V. Vardapetyan, G. A. Shahinyan, A. I. Martiryan","doi":"10.46991/pysu:b/2023.57.2.177","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.2.177","url":null,"abstract":"The study of antioxidants in plants is one of the modern scientific and practical problems. The aim of this work is to obtain the extracts of pharmacy sale juniper berries and seeds, and to study their antioxidant properties by the method of competitive reactions. In this work, a number of extraction methods were used, and the investigation of the obtained extracts was performed by spectrometric and chromatographic methods.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":"199 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.46991/pysu:b/2023.57.2.172
A.L. Varagyan, Gor A. Gevorgyan
Quantitative parameters of total and fecal coliform, as well as Escherichia coli bacteria in the river waters of the Voghji River catchment basin were investigated to characterize fecal contamination in the investigated watershed basin. Water samples for microbial analyses were collected from the Voghji River and its Geghi, Norashenik and Vachagan tributaries in 2016, 2017 and 2020. The results of the study revealed the distribution, potential sources and environmental risks of fecal contamination in the Voghji River catchment basin.
{"title":"MICROBIOLOGICAL ASSESSMENT OF FECAL CONTAMINATION IN THE RIVER WATERS OF THE VOGHJI RIVER CATCHMENT BASIN","authors":"A.L. Varagyan, Gor A. Gevorgyan","doi":"10.46991/pysu:b/2023.57.2.172","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.2.172","url":null,"abstract":"Quantitative parameters of total and fecal coliform, as well as Escherichia coli bacteria in the river waters of the Voghji River catchment basin were investigated to characterize fecal contamination in the investigated watershed basin. Water samples for microbial analyses were collected from the Voghji River and its Geghi, Norashenik and Vachagan tributaries in 2016, 2017 and 2020. The results of the study revealed the distribution, potential sources and environmental risks of fecal contamination in the Voghji River catchment basin.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.46991/pysu:b/2023.57.2.110
A. Tsaturyan
The enantiomers of the chiral compound (2S, 9S)-diamino-2,9-dibenzyldeca-4,6-diynedioic acid and (2R, 9R)-diamino-2,9-dibenzyldeca-4,6-diynedioic acid were separated by a chiral high-performance liquid chromatography (HPLC) method. The separation of α-amino acids was performed using a 5µ 4.0×250 mm column, which was obtained on the basis of a sorbent with eremomycin. The sorbent is silica gel (with 11 nm pore diameter and a surface area of 300 m2/g) with epoxy groups grafted on them with antibiotic eremomycin. Chiral HPLC is one of the most common methods for separating enantiomers of chiral compounds. Synthesis of new pharmaceutical substances, which are one of the isomers of a substance, obtaining of new drugs based on them, as well as the need to control the presence of the second isomer in such drugs, impose new requirements on the modern chromat-ographic separation of isomers.
{"title":"CHIRAL SEPARATION OF $(2S,~9S)$-DIAMINO-2,9-DIBENZYLDECA-4,6-DIYNEDIOIC ACID AND $(2R,~9R)$-DIAMINO-2,9-DIBENZYLDECA-4,6-DIYNEDIOIC ACID","authors":"A. Tsaturyan","doi":"10.46991/pysu:b/2023.57.2.110","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.2.110","url":null,"abstract":"The enantiomers of the chiral compound (2S, 9S)-diamino-2,9-dibenzyldeca-4,6-diynedioic acid and (2R, 9R)-diamino-2,9-dibenzyldeca-4,6-diynedioic acid were separated by a chiral high-performance liquid chromatography (HPLC) method. The separation of α-amino acids was performed using a 5µ 4.0×250 mm column, which was obtained on the basis of a sorbent with eremomycin. The sorbent is silica gel (with 11 nm pore diameter and a surface area of 300 m2/g) with epoxy groups grafted on them with antibiotic eremomycin. Chiral HPLC is one of the most common methods for separating enantiomers of chiral compounds. Synthesis of new pharmaceutical substances, which are one of the isomers of a substance, obtaining of new drugs based on them, as well as the need to control the presence of the second isomer in such drugs, impose new requirements on the modern chromat-ographic separation of isomers.","PeriodicalId":20692,"journal":{"name":"Proceedings of the YSU B: Chemical and Biological Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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