推进临床癌症治疗:揭开表面增强拉曼光谱的神秘面纱

IF 2.4 3区 化学 Q2 SPECTROSCOPY Journal of Raman Spectroscopy Pub Date : 2024-01-04 DOI:10.1002/jrs.6637
Xue Li, Guang Yang, Shuwen Zhang, He Ren
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引用次数: 0

摘要

肿瘤的特点是细胞生长异常,导致细胞增殖失控、侵袭周围组织,并有可能转移到身体其他部位。目前治疗肿瘤的方法包括手术、化疗、放疗、靶向治疗和生物治疗。然而,许多肿瘤在晚期才被发现,限制了这些治疗方法的有效性。因此,有必要开发更灵敏、更高效的技术,以提高患者的存活率。表面增强拉曼散射(SERS)技术是一种高灵敏度的分子检测和表征技术。它可以与组织形态学、免疫标记检测和分子杂交相结合,实现形态、分子和基因层面的定量诊断。SERS 具有客观性、可重复性和可比性等优点。然而,SERS 也面临着一些挑战,包括复杂的底物或探针制备、繁琐的数据分析以及信号的可重复性和可靠性。为了充分发挥 SERS 在生物医学领域和临床转化方面的潜力,必须优化该技术,开发更灵敏、准确和可靠的基底或探针制备和分析方法。本综述旨在全面解释 SERS 技术的机理和独特优势,并探讨其在肿瘤相关研究中的现状、挑战和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Advancing clinical cancer care: Unveiling the power of surface-enhanced Raman spectroscopy

Tumors are characterized by abnormal cell growth, which leads to uncontrolled cell proliferation, invasion of surrounding tissues, and potential metastasis to other parts of the body. Current treatments for tumors include surgery, chemotherapy, radiotherapy, targeted therapy, and biological therapy. However, many tumors are detected at advanced stages, limiting the effectiveness of these treatments. Therefore, there is a need to develop more sensitive and efficient techniques to improve patient survival rates. Surface-enhanced Raman scattering (SERS) technology is a highly sensitive molecular detection and characterization technique. It can be combined with histomorphology, immunolabeling assays, and molecular hybridization to achieve quantitative diagnosis at morphological, molecular, and genetic levels. SERS offers advantages such as objectivity, reproducibility, and comparability. However, there are challenges to address, including complex substrate or probe preparation, cumbersome data analysis, and signal reproducibility and reliability. To fully utilize the potential of SERS in the biomedical field and for clinical translation, it is important to optimize the technology and develop more sensitive, accurate, and reliable substrate or probe preparation and analysis methods. This review aims to comprehensively explain the mechanism and unique advantages of SERS technology and discuss its current status, challenges, and prospects in tumor-related research.

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来源期刊
CiteScore
5.40
自引率
8.00%
发文量
185
审稿时长
3.0 months
期刊介绍: The Journal of Raman Spectroscopy is an international journal dedicated to the publication of original research at the cutting edge of all areas of science and technology related to Raman spectroscopy. The journal seeks to be the central forum for documenting the evolution of the broadly-defined field of Raman spectroscopy that includes an increasing number of rapidly developing techniques and an ever-widening array of interdisciplinary applications. Such topics include time-resolved, coherent and non-linear Raman spectroscopies, nanostructure-based surface-enhanced and tip-enhanced Raman spectroscopies of molecules, resonance Raman to investigate the structure-function relationships and dynamics of biological molecules, linear and nonlinear Raman imaging and microscopy, biomedical applications of Raman, theoretical formalism and advances in quantum computational methodology of all forms of Raman scattering, Raman spectroscopy in archaeology and art, advances in remote Raman sensing and industrial applications, and Raman optical activity of all classes of chiral molecules.
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