Xu Li, Zaiqiang Guo, Chengwei Zhang, Ying Xiong, Chunxia Ding, Ke Wei, Xiaohong Dai, Hui Dai, Yonghuai Ma, Fangcai Lin
{"title":"p73 RS2273953 至 RS1801173 多态性与肺癌风险的关系：对 2,897 例病例和 3,317 例对照的荟萃分析。","authors":"Xu Li, Zaiqiang Guo, Chengwei Zhang, Ying Xiong, Chunxia Ding, Ke Wei, Xiaohong Dai, Hui Dai, Yonghuai Ma, Fangcai Lin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Lung cancer is one of the most common and deadly cancers in humans. <i>P73</i>, a member of the <i>p53</i> family, is a vital gene for the carcinogenesis of lung cancer. Single nucleotide polymorphism (SNP) of <i>P73</i> gene may affect the risk of lung cancer. Therefore, we performed a meta-analysis of <i>p73</i> SNP and lung cancer risk using the most recent data.</p><p><strong>Methods: </strong>A total of 1407 articles from EMBASE, Web of science, PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were identified initially from the search. A meta-analysis of the association between <i>P73</i> polymorphism and lung cancer risk was performed based on various genetic models and by type of lung cancer and race.</p><p><strong>Results: </strong>Seven articles published in either English or Chinese with English abstract were eventually selected for final analysis. The total pooled population included 6214 subjects (2,897 cases and 3,317 controls). The results showed that <i>p73</i> RS2273953 to RS1801173 polymorphism was associated with increased risk of lung cancer in Caucasians but not in Asians. Within Asians, those with <i>p73</i> GC/GC may have an increased risk for squamous carcinoma compared to those with GC/AT+AT/AT polymorphism.</p><p><strong>Conclusions: </strong>Our analysis suggested a lack of association between <i>p73</i> RS2273953 to RS1801173 polymorphism and risk of lung cancer overall. However, patients with GC/GC polymorphism showed an increased risk for squamous carcinoma in the lung compared to those with GC/AT+AT/AT in Asians.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767479/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between p73 RS2273953 to RS1801173 polymorphism and risk of lung cancer: a meta-analysis of 2,897 cases and 3,317 controls.\",\"authors\":\"Xu Li, Zaiqiang Guo, Chengwei Zhang, Ying Xiong, Chunxia Ding, Ke Wei, Xiaohong Dai, Hui Dai, Yonghuai Ma, Fangcai Lin\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Lung cancer is one of the most common and deadly cancers in humans. <i>P73</i>, a member of the <i>p53</i> family, is a vital gene for the carcinogenesis of lung cancer. Single nucleotide polymorphism (SNP) of <i>P73</i> gene may affect the risk of lung cancer. Therefore, we performed a meta-analysis of <i>p73</i> SNP and lung cancer risk using the most recent data.</p><p><strong>Methods: </strong>A total of 1407 articles from EMBASE, Web of science, PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were identified initially from the search. A meta-analysis of the association between <i>P73</i> polymorphism and lung cancer risk was performed based on various genetic models and by type of lung cancer and race.</p><p><strong>Results: </strong>Seven articles published in either English or Chinese with English abstract were eventually selected for final analysis. The total pooled population included 6214 subjects (2,897 cases and 3,317 controls). The results showed that <i>p73</i> RS2273953 to RS1801173 polymorphism was associated with increased risk of lung cancer in Caucasians but not in Asians. Within Asians, those with <i>p73</i> GC/GC may have an increased risk for squamous carcinoma compared to those with GC/AT+AT/AT polymorphism.</p><p><strong>Conclusions: </strong>Our analysis suggested a lack of association between <i>p73</i> RS2273953 to RS1801173 polymorphism and risk of lung cancer overall. However, patients with GC/GC polymorphism showed an increased risk for squamous carcinoma in the lung compared to those with GC/AT+AT/AT in Asians.</p>\",\"PeriodicalId\":13943,\"journal\":{\"name\":\"International journal of clinical and experimental pathology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767479/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of clinical and experimental pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of clinical and experimental pathology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Association between p73 RS2273953 to RS1801173 polymorphism and risk of lung cancer: a meta-analysis of 2,897 cases and 3,317 controls.
Background: Lung cancer is one of the most common and deadly cancers in humans. P73, a member of the p53 family, is a vital gene for the carcinogenesis of lung cancer. Single nucleotide polymorphism (SNP) of P73 gene may affect the risk of lung cancer. Therefore, we performed a meta-analysis of p73 SNP and lung cancer risk using the most recent data.
Methods: A total of 1407 articles from EMBASE, Web of science, PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were identified initially from the search. A meta-analysis of the association between P73 polymorphism and lung cancer risk was performed based on various genetic models and by type of lung cancer and race.
Results: Seven articles published in either English or Chinese with English abstract were eventually selected for final analysis. The total pooled population included 6214 subjects (2,897 cases and 3,317 controls). The results showed that p73 RS2273953 to RS1801173 polymorphism was associated with increased risk of lung cancer in Caucasians but not in Asians. Within Asians, those with p73 GC/GC may have an increased risk for squamous carcinoma compared to those with GC/AT+AT/AT polymorphism.
Conclusions: Our analysis suggested a lack of association between p73 RS2273953 to RS1801173 polymorphism and risk of lung cancer overall. However, patients with GC/GC polymorphism showed an increased risk for squamous carcinoma in the lung compared to those with GC/AT+AT/AT in Asians.
期刊介绍：
The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
