Role of 1,25 Dihydroxycholecalciferol on the Rate of Orthodontic Tooth Movement- A Systematic Review

BACKGROUND: 1,25 dihydroxycholecalciferol, the active form of vitamin D3 is known to play an important role in mineralization. Vitamin D3 is also known to have immune-supporting properties by regulating various cytokines and cell signalling pathways. AIM: To review the role of 1,25-dihydroxycholecalciferol (Vitamin D3) on the rate of Orthodontic tooth movement. METHODS: This study applied a systematic review to analyse the current literature to define and summarise the role of I,25-dihydroxycholecalciferol on the rate of Orthodontic tooth movement. A comprehensive search was done using electronic databases such as PubMed Central, Cochrane Database of Systematic Reviews, Google Scholar, EMBASE and direct web search. The title scan was done to identify relevant articles which are further evaluated for inclusion by reading the abstract. RESULTS: The electronic database search identified 28 articles. 3 articles were selected based on the selection criteria to meet the research question. There was about 60% faster rate of orthodontic tooth movement when a dosage of 40-50 pg/dl of 1,25 dihydroxycholecalciferol was supplemented. Administration of 1,25-dihydroxycholecalciferol showed no deleterious effects to the tooth roots or the surrounding tissues as evidenced from the periapical radiographs and CBCT.  CONCLUSION: Based on the collected data, the local administration of an active form of Vitamin D3, 1,25-dihydroxycholecalciferol can act as an effective supplement to accelerate Orthodontic Tooth  Movement (OTM).