UCP2 与胰腺癌：有意识地解除耦合以达到治疗效果。

IF 7.7 2区医学 Q1 ONCOLOGY Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2024-01-09 DOI:10.1007/s10555-023-10157-4

Emily G Caggiano, Cullen M Taniguchi

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引用次数: 0

摘要

胰腺癌对线粒体代谢的依赖性很强，但如何特异性地靶向线粒体而不对依赖于这些细胞器的正常组织产生脱靶效应是一项重大挑战。线粒体解偶联蛋白 2 (UCP2) 有可能成为癌症特异性药物靶点，因此，我们将回顾 UCP2 的已知生物学特性，并讨论它在胰腺癌病理生物学和未来治疗中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect.

Pancreatic cancer has an exaggerated dependence on mitochondrial metabolism, but methods to specifically target the mitochondria without off target effects in normal tissues that rely on these organelles is a significant challenge. The mitochondrial uncoupling protein 2 (UCP2) has potential as a cancer-specific drug target, and thus, we will review the known biology of UCP2 and discuss its potential role in the pathobiology and future therapy of pancreatic cancer.

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来源期刊

Cancer and Metastasis Reviews 医学-肿瘤学

CiteScore

17.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.