{"title":"苯乙醇和 1-苯基-2-丙醇酶解动力学中作为酰基供体的脂肪酸和芳香酸","authors":"Fatma Zohra Smaine, Mounia Merabet-Khelassi, Saoussen Zeror, Emilie Kolodziej, Martial Toffano, Louisa Aribi-Zouioueche","doi":"10.1007/s00706-023-03147-3","DOIUrl":null,"url":null,"abstract":"<p>The use of fatty and aromatic acids as green acyl donors for enzymatic kinetic resolution via esterification of 1-phenylethanol and 1-phenylpropan-2-ol was described. The impact of the presence of magnesium sulfate on both reactivity and selectivity of <i>Candida rugosa</i> lipase (CRL) was checked. The organic solvents, the medium dilution, and the temperature revealed as determinant parameters to achieve enantioselective esterification reactions. A significant impact of the use of magnesium sulfate was revealed on the enantioselectivity of the CRL in heptane during the resolution of 1-phenylethanol, using butyric and lauric acids as acyl donors.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":19011,"journal":{"name":"Monatshefte für Chemie / Chemical Monthly","volume":"51 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fatty and aromatic acids as acyl donors in enzymatic kinetic resolution of phenylethanol and 1-phenylpropan-2-ol\",\"authors\":\"Fatma Zohra Smaine, Mounia Merabet-Khelassi, Saoussen Zeror, Emilie Kolodziej, Martial Toffano, Louisa Aribi-Zouioueche\",\"doi\":\"10.1007/s00706-023-03147-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The use of fatty and aromatic acids as green acyl donors for enzymatic kinetic resolution via esterification of 1-phenylethanol and 1-phenylpropan-2-ol was described. The impact of the presence of magnesium sulfate on both reactivity and selectivity of <i>Candida rugosa</i> lipase (CRL) was checked. The organic solvents, the medium dilution, and the temperature revealed as determinant parameters to achieve enantioselective esterification reactions. A significant impact of the use of magnesium sulfate was revealed on the enantioselectivity of the CRL in heptane during the resolution of 1-phenylethanol, using butyric and lauric acids as acyl donors.</p><h3 data-test=\\\"abstract-sub-heading\\\">Graphical abstract</h3>\",\"PeriodicalId\":19011,\"journal\":{\"name\":\"Monatshefte für Chemie / Chemical Monthly\",\"volume\":\"51 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Monatshefte für Chemie / Chemical Monthly\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s00706-023-03147-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Monatshefte für Chemie / Chemical Monthly","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00706-023-03147-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Fatty and aromatic acids as acyl donors in enzymatic kinetic resolution of phenylethanol and 1-phenylpropan-2-ol
The use of fatty and aromatic acids as green acyl donors for enzymatic kinetic resolution via esterification of 1-phenylethanol and 1-phenylpropan-2-ol was described. The impact of the presence of magnesium sulfate on both reactivity and selectivity of Candida rugosa lipase (CRL) was checked. The organic solvents, the medium dilution, and the temperature revealed as determinant parameters to achieve enantioselective esterification reactions. A significant impact of the use of magnesium sulfate was revealed on the enantioselectivity of the CRL in heptane during the resolution of 1-phenylethanol, using butyric and lauric acids as acyl donors.
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