{"title":"子宫内膜癌中椭圆形和圆柱形风险器官和目标体积的剂量分析比较","authors":"Yashaswini BR, Tanvir Pasha, Rekha Reddy, Naveen T, Siddanna R Palled, Uday Krishna, Lokesh V, Sridhar P, Nikhila R, Thejaswini B, Chundru Swaroopa","doi":"10.5114/jcb.2023.134171","DOIUrl":null,"url":null,"abstract":"<b>Purpose:</b><br/>To compare dose volume parameters of target and organs at risk in vaginal vault brachytherapy using ovoids or cylinder in post-operative endometrial carcinoma.<br/><br/><b>Material and methods:</b><br/>The study was done among 25 histologically proven post-operative endometrial carcinoma patients requiring vaginal brachytherapy. All patients underwent both cylinder and ovoids application alternatively on weekly basis. Ovoids size ranged from 2 to 3 cm diameter. Diameters of cylinder ranged between 2.5 and 3.5 cm. Bladder, rectum, urethra, and clinical target volume (CTV) were contoured on CT simulation images. Prescribed dose was 6-7 Gy in 2-3 fractions at 0.5 cm from the surface of applicator.<br/><br/><b>Results:</b><br/>The mean values of D<sub>90</sub>, D<sub>50</sub>, V<sub>150</sub>, V<sub>100</sub>, V<sub>90</sub>, and V<sub>50</sub> of CTV were comparable between cylinder and ovoids plans. The mean dose of CTV was significantly higher with cylinder than with ovoids, and D<sub>100</sub> was significantly higher with ovoids (mean = 15.63 Gy vs. 14.64 Gy, <i>p</i> = 0.016, and D<sub>100</sub> = 37.82% vs. 42.86%, <i>p</i> = 0.042, for cylinder vs. ovoids). In the dosimetry of the vault, D<sub>90</sub>, D<sub>50</sub>, V<sub>100</sub>, V<sub>90</sub>, V<sub>50</sub>, and mean of the vault did not show any significant difference between cylinder and ovoids. The V<sub>150</sub> was significantly higher with cylinder plans than ovoids, and D<sub>100</sub> of the vault was significantly higher with ovoids plans (V<sub>150</sub> = 14.81% vs. 6.86%, <i>p</i> = 0.02, and D<sub>100</sub> = 37.77% vs. 44.80%, <i>p</i> = 0.029, for cylinder vs. ovoids). D<sub>0.1cc</sub>, D<sub>1cc</sub>, D<sub>2cc</sub>, and mean for the bladder, rectum, and urethra were comparable between the cylinder and ovoid plans.<br/><br/><b>Conclusions:</b><br/>The present study showed that the dose to organs at risk, most of the dosimetric parameters of CTV, and vault were comparable between the cylinder and ovoid plans. Both applicators provide good reproducibility. The choice of applicator will ultimately depend on the institutional policies and oncologist decision. However, in patients with dog-ear configuration of the vagina, ovoids may be preferred as per ABS guidelines.<br/><br/>","PeriodicalId":51305,"journal":{"name":"Journal of Contemporary Brachytherapy","volume":"127 1","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of dosimetric analysis of organs at risk and target volumes for ovoids and cylinders in endometrial carcinoma\",\"authors\":\"Yashaswini BR, Tanvir Pasha, Rekha Reddy, Naveen T, Siddanna R Palled, Uday Krishna, Lokesh V, Sridhar P, Nikhila R, Thejaswini B, Chundru Swaroopa\",\"doi\":\"10.5114/jcb.2023.134171\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<b>Purpose:</b><br/>To compare dose volume parameters of target and organs at risk in vaginal vault brachytherapy using ovoids or cylinder in post-operative endometrial carcinoma.<br/><br/><b>Material and methods:</b><br/>The study was done among 25 histologically proven post-operative endometrial carcinoma patients requiring vaginal brachytherapy. All patients underwent both cylinder and ovoids application alternatively on weekly basis. Ovoids size ranged from 2 to 3 cm diameter. Diameters of cylinder ranged between 2.5 and 3.5 cm. Bladder, rectum, urethra, and clinical target volume (CTV) were contoured on CT simulation images. Prescribed dose was 6-7 Gy in 2-3 fractions at 0.5 cm from the surface of applicator.<br/><br/><b>Results:</b><br/>The mean values of D<sub>90</sub>, D<sub>50</sub>, V<sub>150</sub>, V<sub>100</sub>, V<sub>90</sub>, and V<sub>50</sub> of CTV were comparable between cylinder and ovoids plans. The mean dose of CTV was significantly higher with cylinder than with ovoids, and D<sub>100</sub> was significantly higher with ovoids (mean = 15.63 Gy vs. 14.64 Gy, <i>p</i> = 0.016, and D<sub>100</sub> = 37.82% vs. 42.86%, <i>p</i> = 0.042, for cylinder vs. ovoids). In the dosimetry of the vault, D<sub>90</sub>, D<sub>50</sub>, V<sub>100</sub>, V<sub>90</sub>, V<sub>50</sub>, and mean of the vault did not show any significant difference between cylinder and ovoids. The V<sub>150</sub> was significantly higher with cylinder plans than ovoids, and D<sub>100</sub> of the vault was significantly higher with ovoids plans (V<sub>150</sub> = 14.81% vs. 6.86%, <i>p</i> = 0.02, and D<sub>100</sub> = 37.77% vs. 44.80%, <i>p</i> = 0.029, for cylinder vs. ovoids). D<sub>0.1cc</sub>, D<sub>1cc</sub>, D<sub>2cc</sub>, and mean for the bladder, rectum, and urethra were comparable between the cylinder and ovoid plans.<br/><br/><b>Conclusions:</b><br/>The present study showed that the dose to organs at risk, most of the dosimetric parameters of CTV, and vault were comparable between the cylinder and ovoid plans. Both applicators provide good reproducibility. The choice of applicator will ultimately depend on the institutional policies and oncologist decision. However, in patients with dog-ear configuration of the vagina, ovoids may be preferred as per ABS guidelines.<br/><br/>\",\"PeriodicalId\":51305,\"journal\":{\"name\":\"Journal of Contemporary Brachytherapy\",\"volume\":\"127 1\",\"pages\":\"\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-12-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Contemporary Brachytherapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5114/jcb.2023.134171\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Contemporary Brachytherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/jcb.2023.134171","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Comparison of dosimetric analysis of organs at risk and target volumes for ovoids and cylinders in endometrial carcinoma
Purpose: To compare dose volume parameters of target and organs at risk in vaginal vault brachytherapy using ovoids or cylinder in post-operative endometrial carcinoma.
Material and methods: The study was done among 25 histologically proven post-operative endometrial carcinoma patients requiring vaginal brachytherapy. All patients underwent both cylinder and ovoids application alternatively on weekly basis. Ovoids size ranged from 2 to 3 cm diameter. Diameters of cylinder ranged between 2.5 and 3.5 cm. Bladder, rectum, urethra, and clinical target volume (CTV) were contoured on CT simulation images. Prescribed dose was 6-7 Gy in 2-3 fractions at 0.5 cm from the surface of applicator.
Results: The mean values of D90, D50, V150, V100, V90, and V50 of CTV were comparable between cylinder and ovoids plans. The mean dose of CTV was significantly higher with cylinder than with ovoids, and D100 was significantly higher with ovoids (mean = 15.63 Gy vs. 14.64 Gy, p = 0.016, and D100 = 37.82% vs. 42.86%, p = 0.042, for cylinder vs. ovoids). In the dosimetry of the vault, D90, D50, V100, V90, V50, and mean of the vault did not show any significant difference between cylinder and ovoids. The V150 was significantly higher with cylinder plans than ovoids, and D100 of the vault was significantly higher with ovoids plans (V150 = 14.81% vs. 6.86%, p = 0.02, and D100 = 37.77% vs. 44.80%, p = 0.029, for cylinder vs. ovoids). D0.1cc, D1cc, D2cc, and mean for the bladder, rectum, and urethra were comparable between the cylinder and ovoid plans.
Conclusions: The present study showed that the dose to organs at risk, most of the dosimetric parameters of CTV, and vault were comparable between the cylinder and ovoid plans. Both applicators provide good reproducibility. The choice of applicator will ultimately depend on the institutional policies and oncologist decision. However, in patients with dog-ear configuration of the vagina, ovoids may be preferred as per ABS guidelines.
期刊介绍：
The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.
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