{"title":"通过单细胞方法了解环境对侵袭性乳腺癌的影响","authors":"David Aguilar Jr. , Justin A. Colacino","doi":"10.1016/j.cotox.2024.100459","DOIUrl":null,"url":null,"abstract":"<div><p><span>Breast cancer is a heterogeneous suite of diseases, with likely strong, but still poorly understood, environmental etiologies. New advances in single cell methods are now poised to help us understand how environmental exposures, such as air and water pollutants, diet, personal and consumer care products, and social factors, may promote the development of aggressive breast cancers. In this review, we describe how dissociated and spatial single cell transcriptomic analyses can be used to advance our understanding how our environment impacts </span>breast carcinogenesis through the view of frameworks such as the Hallmarks of Cancer and the Key Characteristics of Carcinogens.</p></div>","PeriodicalId":93968,"journal":{"name":"Current opinion in toxicology","volume":"37 ","pages":"Article 100459"},"PeriodicalIF":4.6000,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Single cell approaches to understand environmental impacts on aggressive breast cancers\",\"authors\":\"David Aguilar Jr. , Justin A. Colacino\",\"doi\":\"10.1016/j.cotox.2024.100459\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Breast cancer is a heterogeneous suite of diseases, with likely strong, but still poorly understood, environmental etiologies. New advances in single cell methods are now poised to help us understand how environmental exposures, such as air and water pollutants, diet, personal and consumer care products, and social factors, may promote the development of aggressive breast cancers. In this review, we describe how dissociated and spatial single cell transcriptomic analyses can be used to advance our understanding how our environment impacts </span>breast carcinogenesis through the view of frameworks such as the Hallmarks of Cancer and the Key Characteristics of Carcinogens.</p></div>\",\"PeriodicalId\":93968,\"journal\":{\"name\":\"Current opinion in toxicology\",\"volume\":\"37 \",\"pages\":\"Article 100459\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468202024000019\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202024000019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Single cell approaches to understand environmental impacts on aggressive breast cancers
Breast cancer is a heterogeneous suite of diseases, with likely strong, but still poorly understood, environmental etiologies. New advances in single cell methods are now poised to help us understand how environmental exposures, such as air and water pollutants, diet, personal and consumer care products, and social factors, may promote the development of aggressive breast cancers. In this review, we describe how dissociated and spatial single cell transcriptomic analyses can be used to advance our understanding how our environment impacts breast carcinogenesis through the view of frameworks such as the Hallmarks of Cancer and the Key Characteristics of Carcinogens.