通过单细胞方法了解环境对侵袭性乳腺癌的影响

David Aguilar Jr. , Justin A. Colacino
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引用次数: 0

摘要

乳腺癌是一种异质性疾病,其环境病因可能很强,但人们对其仍然知之甚少。现在,单细胞方法的新进展有望帮助我们了解环境暴露(如空气和水污染物、饮食、个人和消费者护理产品以及社会因素)如何促进侵袭性乳腺癌的发展。在这篇综述中,我们将介绍如何利用分离和空间单细胞转录组分析,通过癌症标志和致癌物关键特征等框架,加深我们对环境如何影响乳腺癌发生的理解。
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Single cell approaches to understand environmental impacts on aggressive breast cancers

Breast cancer is a heterogeneous suite of diseases, with likely strong, but still poorly understood, environmental etiologies. New advances in single cell methods are now poised to help us understand how environmental exposures, such as air and water pollutants, diet, personal and consumer care products, and social factors, may promote the development of aggressive breast cancers. In this review, we describe how dissociated and spatial single cell transcriptomic analyses can be used to advance our understanding how our environment impacts breast carcinogenesis through the view of frameworks such as the Hallmarks of Cancer and the Key Characteristics of Carcinogens.

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来源期刊
Current opinion in toxicology
Current opinion in toxicology Toxicology, Biochemistry
CiteScore
8.50
自引率
0.00%
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0
审稿时长
64 days
期刊最新文献
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