您的电子鼻对癌症的检测效果如何?应用人工呼气分析进行性能评估。

IF 3.7 4区 医学 Q1 BIOCHEMICAL RESEARCH METHODS Journal of breath research Pub Date : 2024-01-22 DOI:10.1088/1752-7163/ad1d64
Justin D M Martin, Falzone Claudia, Anne-Claude Romain
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引用次数: 0

摘要

由于缺乏标准化的方法,比较电子鼻的性能是一项具有挑战性的任务。本文提出了一种通过人工呼气分析来定义和量化多传感器系统检测癌症有效性指标的方法。为了建立这种方法,我们对用于肺癌筛查工具的金属氧化物传感器阵列的性能进行了评估。20 名健康志愿者的呼吸样本被装入 FEP 采样袋中。在分析这些健康样本时,分别添加和不添加从文献中选择的 9 种挥发性有机化合物癌症生物标志物。添加的挥发性有机化合物的浓度逐量增加。添加的挥发性有机化合物越多,"健康 "样本(未添加添加剂的呼气)和 "癌症 "样本(添加添加剂的呼气)之间的区分度就越高。通过确定电子鼻在哪种浓度水平上无法可靠地区分两组,我们可以估算出电子鼻在现实情况下预测疾病存在与否的能力。在这项工作中,我们对自制的电子鼻进行了测试。结果表明,生物标记物的浓度需要比真实呼吸浓度高出约 5.3 倍,自制电子鼻才能以足够的可信度区分不同组别。
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How well does your e-nose detect cancer? Application of artificial breath analysis for performance assessment.

Comparing electronic nose (e-nose) performance is a challenging task because of a lack of standardised method. This paper proposes a method for defining and quantifying an indicator of the effectiveness of multi-sensor systems in detecting cancers by artificial breath analysis. To build this method, an evaluation of the performances of an array of metal oxide sensors built for use as a lung cancer screening tool was conducted. Breath from 20 healthy volunteers has been sampled in fluorinated ethylene propylene sampling bags. These healthy samples were analysed with and without the addition of nine volatile organic compound (VOC) cancer biomarkers, chosen from literature. The concentration of the VOC added was done in increasing amounts. The more VOC were added, the better the discrimination between 'healthy' samples (breath without additives) and 'cancer' samples (breath with additives) was. By determining at which level of concentration the e-nose fails to reliably discriminate between the two groups, we estimate its ability to well predict the presence of the disease or not in a realistic situation. In this work, a home-made e-nose is put to the test. The results underline that the biomarkers need to be about 5.3 times higher in concentration than in real breath for the home-made nose to tell the difference between groups with a sufficient confidence.

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来源期刊
Journal of breath research
Journal of breath research BIOCHEMICAL RESEARCH METHODS-RESPIRATORY SYSTEM
CiteScore
7.60
自引率
21.10%
发文量
49
审稿时长
>12 weeks
期刊介绍: Journal of Breath Research is dedicated to all aspects of scientific breath research. The traditional focus is on analysis of volatile compounds and aerosols in exhaled breath for the investigation of exogenous exposures, metabolism, toxicology, health status and the diagnosis of disease and breath odours. The journal also welcomes other breath-related topics. Typical areas of interest include: Big laboratory instrumentation: describing new state-of-the-art analytical instrumentation capable of performing high-resolution discovery and targeted breath research; exploiting complex technologies drawn from other areas of biochemistry and genetics for breath research. Engineering solutions: developing new breath sampling technologies for condensate and aerosols, for chemical and optical sensors, for extraction and sample preparation methods, for automation and standardization, and for multiplex analyses to preserve the breath matrix and facilitating analytical throughput. Measure exhaled constituents (e.g. CO2, acetone, isoprene) as markers of human presence or mitigate such contaminants in enclosed environments. Human and animal in vivo studies: decoding the ''breath exposome'', implementing exposure and intervention studies, performing cross-sectional and case-control research, assaying immune and inflammatory response, and testing mammalian host response to infections and exogenous exposures to develop information directly applicable to systems biology. Studying inhalation toxicology; inhaled breath as a source of internal dose; resultant blood, breath and urinary biomarkers linked to inhalation pathway. Cellular and molecular level in vitro studies. Clinical, pharmacological and forensic applications. Mathematical, statistical and graphical data interpretation.
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