基于细胞的免疫疗法中的免疫逃避:揭示挑战与新策略。

IF 9 2区 医学 Q1 CELL BIOLOGY Journal of Biomedical Science Pub Date : 2024-01-12 DOI:10.1186/s12929-024-00998-8
Yan-Ruide Li, Tyler Halladay, Lili Yang
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引用次数: 0

摘要

以细胞为基础的免疫疗法(CBIs),特别是嵌合抗原受体(CAR)工程T(CAR-T)细胞疗法,已成为癌症治疗的突破性方法。然而,与其他各种治疗方法一样,肿瘤细胞也会采取反策略来逃避免疫,从而规避CBIs的影响。肿瘤微环境(TME)中错综复杂的免疫抑制促进了这一现象的发生。肿瘤免疫逃避 CBIs 的主要机制包括抗原丢失、抗原递呈下调、免疫检查点通路激活、抗凋亡级联启动以及诱导免疫功能紊乱和衰竭。在这篇综述中,我们将深入探讨肿瘤细胞抵抗 CBI 的内在机制,并提出应对这些挑战的前瞻性策略。
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Immune evasion in cell-based immunotherapy: unraveling challenges and novel strategies.

Cell-based immunotherapies (CBIs), notably exemplified by chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy, have emerged as groundbreaking approaches for cancer therapy. Nevertheless, akin to various other therapeutic modalities, tumor cells employ counterstrategies to manifest immune evasion, thereby circumventing the impact of CBIs. This phenomenon is facilitated by an intricately immunosuppression entrenched within the tumor microenvironment (TME). Principal mechanisms underpinning tumor immune evasion from CBIs encompass loss of antigens, downregulation of antigen presentation, activation of immune checkpoint pathways, initiation of anti-apoptotic cascades, and induction of immune dysfunction and exhaustion. In this review, we delve into the intrinsic mechanisms underlying the capacity of tumor cells to resist CBIs and proffer prospective stratagems to navigate around these challenges.

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来源期刊
Journal of Biomedical Science
Journal of Biomedical Science 医学-医学:研究与实验
CiteScore
18.50
自引率
0.90%
发文量
95
审稿时长
1 months
期刊介绍: The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.
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